Time-resolved spectroscopic and electrophysiological data reveal insights in the gating mechanism of anion channelrhodopsin

URN to cite this document:: urn:nbn:de:bvb:355-epub-751543
DOI to cite this document:: 10.5283/epub.75154

Dreier, Max-Aylmer ; Althoff, Philipp ; Norahan, Mohamad Javad ; Tennigkeit, Stefan Alexander

; El-Mashtoly, Samir F. ; Lübben, Mathias

; Kötting, Carsten

; Rudack, Till

; Gerwert, Klaus

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 20 Mar 2025 07:17

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Abstract

Channelrhodopsins are widely used in optogenetic applications. High photocurrents and low current inactivation levels are desirable. Two parallel photocycles evoked by different retinal conformations cause cation-conducting channelrhodopsin-2 (CrChR2) inactivation: one with efficient conductivity; one with low conductivity. Given the longer half-life of the low conducting photocycle ...