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Graham, Emily ; Harbron, Chris ; Jaki, Thomas

Updating the probability of study success for combination therapies using related combination study data

Graham, Emily , Harbron, Chris und Jaki, Thomas (2023) Updating the probability of study success for combination therapies using related combination study data. Statistical Methods in Medical Research 32 (4), S. 712-731.

Veröffentlichungsdatum dieses Volltextes: 18 Mrz 2025 10:06
Artikel
DOI zum Zitieren dieses Dokuments: 10.5283/epub.75868


Zusammenfassung

Combination therapies are becoming increasingly used in a range of therapeutic areas such as oncology and infectious diseases, providing potential benefits such as minimising drug resistance and toxicity. Sets of combination studies may be related, for example, if they have at least one treatment in common and are used in the same indication. In this setting, value can be gained by sharing ...

Combination therapies are becoming increasingly used in a range of therapeutic areas such as oncology and infectious diseases, providing potential benefits such as minimising drug resistance and toxicity. Sets of combination studies may be related, for example, if they have at least one treatment in common and are used in the same indication. In this setting, value can be gained by sharing information between related combination studies. We present a framework that allows the study success probabilities of a set of related combination therapies to be updated based on the outcome of a single combination study. This allows us to incorporate both direct and indirect data on a combination therapy in the decision-making process for future studies. We also provide a robustification that accounts for the fact that the prior assumptions on the correlation structure of the set of combination therapies may be incorrect. We show how this framework can be used in practice and highlight the use of the study success probabilities in the planning of clinical studies.



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Details

DokumentenartArtikel
Titel eines Journals oder einer ZeitschriftStatistical Methods in Medical Research
Verlag:Sage
Ort der Veröffentlichung:LONDON
Band:32
Nummer des Zeitschriftenheftes oder des Kapitels:4
Seitenbereich:S. 712-731
Datum12 Februar 2023
InstitutionenInformatik und Data Science > Fachbereich Maschinelles Lernen und Data Science > Chair for Computational Statistics (Prof. Dr. Thomas Jaki)
Identifikationsnummer
WertTyp
10.1177/09622802231151218DOI
Stichwörter / KeywordsCLINICAL-TRIALS; PHASE-II; TRASTUZUMAB; PERTUZUMAB; DOCETAXEL; POWER; END; Combination therapies; clinical trials; probability of success; Bayesian; assurance
Dewey-Dezimal-Klassifikation000 Informatik, Informationswissenschaft, allgemeine Werke > 004 Informatik
StatusVeröffentlicht
BegutachtetJa, diese Version wurde begutachtet
An der Universität Regensburg entstandenNein
URN der UB Regensburgurn:nbn:de:bvb:355-epub-758684
Dokumenten-ID75868

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