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Graham, Emily ; Harbron, Chris ; Jaki, Thomas

Updating the probability of study success for combination therapies using related combination study data

Graham, Emily , Harbron, Chris and Jaki, Thomas (2023) Updating the probability of study success for combination therapies using related combination study data. Statistical Methods in Medical Research 32 (4), pp. 712-731.

Date of publication of this fulltext: 18 Mar 2025 10:06
Article
DOI to cite this document: 10.5283/epub.75868


Abstract

Combination therapies are becoming increasingly used in a range of therapeutic areas such as oncology and infectious diseases, providing potential benefits such as minimising drug resistance and toxicity. Sets of combination studies may be related, for example, if they have at least one treatment in common and are used in the same indication. In this setting, value can be gained by sharing ...

Combination therapies are becoming increasingly used in a range of therapeutic areas such as oncology and infectious diseases, providing potential benefits such as minimising drug resistance and toxicity. Sets of combination studies may be related, for example, if they have at least one treatment in common and are used in the same indication. In this setting, value can be gained by sharing information between related combination studies. We present a framework that allows the study success probabilities of a set of related combination therapies to be updated based on the outcome of a single combination study. This allows us to incorporate both direct and indirect data on a combination therapy in the decision-making process for future studies. We also provide a robustification that accounts for the fact that the prior assumptions on the correlation structure of the set of combination therapies may be incorrect. We show how this framework can be used in practice and highlight the use of the study success probabilities in the planning of clinical studies.



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Details

Item typeArticle
Journal or Publication TitleStatistical Methods in Medical Research
Publisher:Sage
Open Access Type:CC-License
Place of Publication:LONDON
Volume:32
Number of Issue or Book Chapter:4
Page Range:pp. 712-731
Date12 February 2023
InstitutionsInformatics and Data Science > Department Machine Learning & Data Science > Lehrstuhl für Computational Statistics (Prof. Dr. Thomas Jaki)
Identification Number
ValueType
10.1177/09622802231151218DOI
KeywordsCLINICAL-TRIALS; PHASE-II; TRASTUZUMAB; PERTUZUMAB; DOCETAXEL; POWER; END; Combination therapies; clinical trials; probability of success; Bayesian; assurance
Dewey Decimal Classification000 Computer science, information & general works > 004 Computer science
StatusPublished
RefereedYes, this version has been refereed
Created at the University of RegensburgNo
URN of the UB Regensburgurn:nbn:de:bvb:355-epub-758684
Item ID75868

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