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Minimally important differences for interpreting EORTC QLQ-C30 change scores over time: A synthesis across 21 clinical trials involving nine different cancer types

Musoro, Jammbe Z. ; Coens, Corneel ; Sprangers, Mirjam A.G. ; Brandberg, Yvonne ; Groenvold, Mogens ; Flechtner, Hans-Henning ; Cocks, Kim ; Velikova, Galina ; Dirven, Linda ; Greimel, Elfriede ; Singer, Susanne ; Pogoda, Katarzyna ; Gamper, Eva M. ; Sodergren, Samantha C. ; Eggermont, Alexander ; Koller, Michael ; Reijneveld, Jaap C. ; Taphoorn, Martin J.B. ; King, Madeleine T. ; Bottomley, Andrew



Abstract

Introduction: Early guidelines for minimally important differences (MIDs) for the EORTC QLQ-C30 proposed & GE;10 points change as clinically meaningful for all scales. Increasing evidence that MIDs can vary by scale, direction of change, cancer type and estimation method has raised doubt about a single global standard. This paper identifies MID patterns for interpreting group-level change in ...

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