Primary and secondary metastatic dissemination: multiple routes to cancer-related death

URN to cite this document:: urn:nbn:de:bvb:355-epub-773716
DOI to cite this document:: 10.5283/epub.77371

Sparrer, D. ; Blazquez, R. ; Keil, F. ; Einhell, S. ; Lüke, F. ; Uderhardt, S. ; Gerner, C. ; Wendl, C. H. R. ; Proescholdt, Martin ; Schulz, C. ; Kandulski, Arne ; Haferkamp, Sebastian ; Schlitt, H. J. ; Bäuerle, T. ; Franze, K. ; Mayr, R. ; Rechenmacher, M. ; Hau, Peter ; Hirsch, D. ; Heudobler, Daniel ; Evert, Katja ; Pukrop, Tobias

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Date of publication of this fulltext: 23 Jul 2025 06:35

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Abstract

Metastatic disease accounts for approximately 80% of cancer-related deaths, typically manifesting as single-organ failure mainly through abdominal, cardiovascular, neurological, or respiratory complications. Despite treating thousands of cancer patients daily worldwide, our understanding of organ-specific metastatic dissemination routes, tissue destruction mechanisms and reasons for organ ...