How to add baskets to an ongoing basket trial with information borrowing

URN to cite this document:: urn:nbn:de:bvb:355-epub-777173
DOI to cite this document:: 10.5283/epub.77717

Daniells, Libby

; Mozgunov, Pavel

; Barnett, Helen ; Bedding, Alun ; Jaki, Thomas

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 22 Sep 2025 05:39

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Abstract

Basket trials test a single therapeutic treatment on several patient populations under one master protocol. A desirable adaptive design feature is the ability to incorporate new baskets to an ongoing trial. Limited basket sample sizes can result in reduced power and precision of treatment effect estimates, which could be amplified in added baskets due to the shorter recruitment time. While ...