A Preplanned Multi‐Stage Platform Trial for Discovering Multiple Superior Treatments With Control of FWER and Power

URN to cite this document:: urn:nbn:de:bvb:355-epub-777200
DOI to cite this document:: 10.5283/epub.77720

Greenstreet, Peter ; Jaki, Thomas

; Bedding, Alun ; Mozgunov, Pavel

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 22 Sep 2025 05:32

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Abstract

There is a growing interest in the implementation of platform trials, which provide the flexibility to incorporate new treatment arms during the trial and the ability to halt treatments early based on lack of benefit or observed superiority. In such trials, it can be important to ensure that error rates are controlled. This paper introduces a multi-stage design that enables the addition of new ...