A multi‐arm multi‐stage platform design that allows preplanned addition of arms while still controlling the family‐wise error

URN to cite this document:: urn:nbn:de:bvb:355-epub-777725
DOI to cite this document:: 10.5283/epub.77772

Greenstreet, Peter ; Jaki, Thomas

; Bedding, Alun ; Harbron, Chris ; Mozgunov, Pavel

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 22 Sep 2025 07:13

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Abstract

There is growing interest in platform trials that allow for adding of new treatment arms as the trial progresses as well as being able to stop treatments part way through the trial for either lack of benefit/futility or for superiority. In some situations, platform trials need to guarantee that error rates are controlled. This paper presents a multi-stage design, that allows additional arms to be ...