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A novel statistical test for treatment differences in clinical trials using a response‐adaptive forward‐looking Gittins Index Rule
Barnett, Helen Yvette, Villar, Sofía S., Geys, Helena und Jaki, Thomas
(2021)
A novel statistical test for treatment differences in clinical trials using a response‐adaptive forward‐looking Gittins Index Rule.
Biometrics 79 (1), S. 86-97.
Veröffentlichungsdatum dieses Volltextes: 29 Sep 2025 10:00
Artikel
DOI zum Zitieren dieses Dokuments: 10.5283/epub.77850
Zusammenfassung
The most common objective for response-adaptive clinical trials is to seek to ensure that patients within a trial have a high chance of receiving the best treatment available by altering the chance of allocation on the basis of accumulating data. Approaches that yield good patient benefit properties suffer from low power from a frequentist perspective when testing for a treatment difference at ...
The most common objective for response-adaptive clinical trials is to seek to ensure that patients within a trial have a high chance of receiving the best treatment available by altering the chance of allocation on the basis of accumulating data. Approaches that yield good patient benefit properties suffer from low power from a frequentist perspective when testing for a treatment difference at the end of the study due to the high imbalance in treatment allocations. In this work we develop an alternative pairwise test for treatment difference on the basis of allocation probabilities of the covariate-adjusted response-adaptive randomization with forward-looking Gittins Index (CARA-FLGI) Rule for binary responses. The performance of the novel test is evaluated in simulations for two-armed studies and then its applications to multiarmed studies are illustrated. The proposed test has markedly improved power over the traditional Fisher exact test when this class of nonmyopic response adaptation is used. We also find that the test's power is close to the power of a Fisher exact test under equal randomization.
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Details
| Dokumentenart | Artikel | ||||
| Titel eines Journals oder einer Zeitschrift | Biometrics | ||||
| Verlag: | Oxford Academic, Oxford University Press | ||||
|---|---|---|---|---|---|
| Band: | 79 | ||||
| Nummer des Zeitschriftenheftes oder des Kapitels: | 1 | ||||
| Seitenbereich: | S. 86-97 | ||||
| Datum | 20 Oktober 2021 | ||||
| Institutionen | Informatik und Data Science > Fachbereich Maschinelles Lernen und Data Science > Chair for Computational Statistics (Prof. Dr. Thomas Jaki) | ||||
| Identifikationsnummer |
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| Stichwörter / Keywords | allocation probability, inference, nonmyopic, power, testing for superiority | ||||
| Dewey-Dezimal-Klassifikation | 000 Informatik, Informationswissenschaft, allgemeine Werke > 004 Informatik | ||||
| Status | Veröffentlicht | ||||
| Begutachtet | Ja, diese Version wurde begutachtet | ||||
| An der Universität Regensburg entstanden | Nein | ||||
| URN der UB Regensburg | urn:nbn:de:bvb:355-epub-778505 | ||||
| Dokumenten-ID | 77850 |
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