A novel statistical test for treatment differences in clinical trials using a response‐adaptive forward‐looking Gittins Index Rule

URN to cite this document:: urn:nbn:de:bvb:355-epub-778505
DOI to cite this document:: 10.5283/epub.77850

Barnett, Helen Yvette ; Villar, Sofía S. ; Geys, Helena ; Jaki, Thomas

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 29 Sep 2025 10:00

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Abstract

The most common objective for response-adaptive clinical trials is to seek to ensure that patients within a trial have a high chance of receiving the best treatment available by altering the chance of allocation on the basis of accumulating data. Approaches that yield good patient benefit properties suffer from low power from a frequentist perspective when testing for a treatment difference at ...