The influence of psychosocial stress on functional connectivity and neuroendocrine markers in adolescents with depressive and comorbid anxiety disorders: a study protocol

URN to cite this document:: urn:nbn:de:bvb:355-epub-784294
DOI to cite this document:: 10.5283/epub.78429

Jacob, Ricarda

; Otto, Alexandra

; Jarvers, Irina

; Kandsperger, Stephanie

; Ecker, Angelika

; Schleicher, Daniel

; Malloni, Wilhelm M. ; Neumann, Inga D.

; Brunner, Romuald

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 15 Jan 2026 05:31

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Abstract

Background Psychosocial stress is a major risk factor for adolescent depression and anxiety, impacting neurodevelopment through hypothalamic-pituitary-adrenal axis and oxytocinergic system dysregulation. Stress-related alterations in fronto-limbic resting-state functional connectivity (rsFC) have been linked to depression and anxiety disorders, yet the role of oxytocin in these processes remains ...