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An improved diffusion/compartmental model for transdermal drug delivery from a matrix-type device

URN to cite this document:
urn:nbn:de:bvb:355-epub-85142
DOI to cite this document:
10.5283/epub.8514
Göpferich, Achim ; Lee, Geoffrey
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Date of publication of this fulltext: 05 Aug 2009 13:59


Abstract

A mathematical model is presented for the description of transdermal drug delivery from a matrix-type delivery device. The model is partly diffusional and partly compartmental in nature. The matrix and stratum corneum are both considered to be diffusion layers, connected to a three-compartment model representing the viable epidermis/dermis, plasma, and peripheral tissues. The diffusion equation ...

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