An improved diffusion/compartmental model for transdermal drug delivery from a matrix-type device

URN to cite this document:: urn:nbn:de:bvb:355-epub-85142
DOI to cite this document:: 10.5283/epub.8514

Göpferich, Achim ; Lee, Geoffrey

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Date of publication of this fulltext: 05 Aug 2009 13:59

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Item type:	Article
Journal or Publication Title:	International Journal of Pharmaceutics
Publisher:	Elsevier
Volume:	71
Number of Issue or Book Chapter:	3
Page Range:	pp. 237-243
Date:	1991
Institutions:	Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich)
Keywords:	TRANSDERMAL DRUG DELIVERY; POLYMER MATRIX; MODEL
Dewey Decimal Classification:	500 Science > 570 Life sciences 600 Technology > 610 Medical sciences Medicine
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	No
Item ID:	8514

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Abstract

A mathematical model is presented for the description of transdermal drug delivery from a matrix-type delivery device. The model is partly diffusional and partly compartmental in nature. The matrix and stratum corneum are both considered to be diffusion layers, connected to a three-compartment model representing the viable epidermis/dermis, plasma, and peripheral tissues. The diffusion equation ...