Use of donor serum to prevent passive transfer of hyperacute rejection

URN to cite this document:: urn:nbn:de:bvb:355-epub-95529

Wang, Jue ; Geissler, Edward K. ; Fechner, John H. ; Burlingham, William J. ; Knechtle, Stuart J.

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Date of publication of this fulltext: 22 Sep 2009 12:16

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Abstract

Organ transplantation in presensitized recipients continues to be contraindicated for heart and kidney recipients due to the risk of hyperacute rejection, which has no known treatment at this time. We tested whether donor serum, which contains soluble MHC class I antigen, is able to neutralize the effect of anti-donor antibody in the recipient and prevent hyperacute or accelerated rejection. A ...