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Identification and characterization of genes with specific expression in dendritic cells

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Heinz, Sven
Date of publication of this fulltext: 09 Jul 2003 13:08

Abstract (German)

Dendritische Zellen (DC) gehören neben Makrophagen und B-Lymphozyten zu den professionellen antigenpräsentierenden Zellen (APC) des Körpers. Bisher sind nur wenige DC-spezifisch exprimierte Markergene bekannt. Im Rahmen dieser Arbeit wurden über Repräsentationsdifferenzanalyse (RDA) der Expressionsprofile von aus Monozyten in vitro generierten DC versus Monozyten und parallel aus Monozyten ...


Translation of the abstract (English)

To gain further insight into the differentiation pathways and lineage-commitment steps of dendritic cells (DCs) vs. macrophages as well as to define new molecular DC markers, genes with specific expression in DCs during differentiation from blood monocytes were identified by representational difference analysis (RDA). Subsequently, the expression pattern of the genes, namely DC-CK1, 15-LOX, ...


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