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Identification and characterization of genes with specific expression in dendritic cells

Heinz, Sven (2003) Identification and characterization of genes with specific expression in dendritic cells. PhD, Universität Regensburg.

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Date of publication of this fulltext: 09 Jul 2003 13:08

Abstract (German)

Dendritische Zellen (DC) gehören neben Makrophagen und B-Lymphozyten zu den professionellen antigenpräsentierenden Zellen (APC) des Körpers. Bisher sind nur wenige DC-spezifisch exprimierte Markergene bekannt. Im Rahmen dieser Arbeit wurden über Repräsentationsdifferenzanalyse (RDA) der Expressionsprofile von aus Monozyten in vitro generierten DC versus Monozyten und parallel aus Monozyten ...


Translation of the abstract (English)

To gain further insight into the differentiation pathways and lineage-commitment steps of dendritic cells (DCs) vs. macrophages as well as to define new molecular DC markers, genes with specific expression in DCs during differentiation from blood monocytes were identified by representational difference analysis (RDA). Subsequently, the expression pattern of the genes, namely DC-CK1, 15-LOX, ...


Export bibliographical data

Item type:Thesis of the University of Regensburg (PhD)
Date:8 July 2003
Referee:Prof. Dr. Armin Buschauer and PD Dr. S. W. Krause
Date of exam:18 July 2002
Institutions:Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
molecular biologyNASA
Keywords:Dendritische Zelle , Monozyten-Makrophagen-System , Genexpression , Genregulation , MCP-4 , Hep27 (DHRS2) , Promotor , CpG-Methylierung , MCP-4 , Hep27 (DHRS2) , 15-Lipoxygenase , complement C1q C-chain , folate receptor beta
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:10104
Owner only: item control page


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