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Structure-based design of hyaluronidase inhibitors

Botzki, Alexander (2004) Structure-based design of hyaluronidase inhibitors. PhD, Universität Regensburg.

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Date of publication of this fulltext: 14 Jun 2004 15:34

Abstract (English)

Hyaluronan and hyaluronidases have been used in several medical fields for many years and some hyaluronidases play a role in, e.g., meningitis, septicaemia, arthroses and cancer. To further investigate the function of hyaluronan and hyaluronidases in (patho)physiological processes, selective and potent hyaluronidase inhibitors are required. Originated by the lack of such compounds, the main goal ...

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Translation of the abstract (German)

Hyaluronsäure und Hyaluronidasen wurden seit Jahren in verschiedenen medizinischen Bereichen eingesetzt und Hyaluronidasen spielen eine Rolle bei z.B. Meningitis, Septikämie, Arthrosen und Krebs. Selektive und potente Inhibitoren werden zur Aufklärung der Funktion von Hyaluronsäure und Hyaluronidasen in (patho)physiologischen Prozessen benötigt. Motiviert durch das Fehlen solcher Verbindungen war ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:13 June 2004
Referee:Prof. Dr. Armin Buschauer
Date of exam:11 May 2004
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Keywords:Hyaluronidasen , Hyaluronsäure , Enzyminhibitor , Molekulardesign , , hyaluronidase , hyaluronic acid , enzyme inhibitor , molecular design , virtual screening
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:10202
Owner only: item control page

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