Brennauer, Albert (2006) Acylguanidines as bioisosteric groups in argininamide-type neuropeptide Y Y1 and Y2 receptor antagonists: synthesis, stability and pharmacological activity. PhD, Universität Regensburg.
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Abstract (English)
We developed multi-step synthetic routes for the preparation of two classes of N(G)-substituted argininamides with neuropeptide Y Y1 and Y2 receptor selective antagonistic activity, respectively. In both series we could identify N(G)-acylated analogs being even more potent than the respective N(G)-unsubstituted compounds, which are established as standard Y1- (BIBP 3226) and Y2-antagonists (BIIE ...
Translation of the abstract (German)
Wir beschäftigten uns mit der Synthese von zwei verschiedenen Klassen von N(G)-substituierten Argininamiden mit Neuropeptid Y Y1- bzw. Y2-rezeptorselektiver antagonistischer Wirkung. In beiden Serien fanden sich N(G)-acylierte Analogverbindungen, die potenter sind als die entsprechenden unsubstituierten Verbindungen BIBP 3226 und BIIE 0246, die als Standard Y1- bzw. Y2-Rezeptorantagonisten in der ...
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| Item type: | Thesis of the University of Regensburg (PhD) |
|---|---|
| Date: | 14 December 2006 |
| Referee: | Prof. Dr. Armin Buschauer |
| Date of exam: | 11 September 2006 |
| Institutions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer) |
| Keywords: | Neuropeptid Y , Pharmakologischer Antagonist , Argininderivate , Guanidinderivate , Peptidomimetikum , Organische Synthese , Amide , Chemische Synthese , Rezeptor , NPY Rezeptoren , Y1 Rezeptor , Y2 Rezeptor , BIBP 3226 , BIIE 0246 , Guanidinylierung , NPY receptors , Y1 receptor , Y2 receptor , BIBP 3226 , BIIE 0246 , guanidinylation |
| Dewey Decimal Classification: | 500 Science > 540 Chemistry & allied sciences |
| Status: | Published |
| Refereed: | Yes, this version has been refereed |
| Created at the University of Regensburg: | Yes |
| Item ID: | 10487 |
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