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Synthese und funktionelle in-vitro-Pharmakologie neuer Histamin-H1-Rezeptoragonisten aus der Suprahistaprodifen-Reihe

Striegl, Birgit (2007) Synthese und funktionelle in-vitro-Pharmakologie neuer Histamin-H1-Rezeptoragonisten aus der Suprahistaprodifen-Reihe. PhD, Universität Regensburg.

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Date of publication of this fulltext: 02 Jul 2007 08:10

Abstract (German)

Ausgehend von Suprahistaprodifen als Leitstruktur, das mit 3600% der Histamin¬wirkung am Meerschweinchen-Ileum (MS-Ileum) den bislang potentesten publizierten Histamin-H1-Rezeptoragonisten darstellt, wurde eine neue Klasse von Histaprodifenen synthetisiert und in verschiedenen, funktionellen in vitro-Assays charakterisiert. Die Darstellung der N(alpha)-substituierten Histaprodifene erfolgte durch ...


Translation of the abstract (English)

A new class of histaprodifen derivatives has been prepared and characterized by different functional in-vitro assays. Suprahistaprodifen, the most potent histamine H1-receptor agonist described so far (3600% of histamine potency in the guinea-pig ileum assay), was used as a lead compound for the development of the structures described in this work. The new N(alpha)-imidazolylalkyl substituted ...


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Item type:Thesis of the University of Regensburg (PhD)
Date:1 July 2007
Referee:Sigurd (Prof. Dr.) Elz
Date of exam:4 July 2006
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry I (Prof. Elz)
Keywords:Histaminrezeptor , Pharmakologie , Histamin-H1-Rezeptoragonisten , Histaprodifen , Suprahistaprodifen , Meerschweinchen-Ileum , GTPase Assay , histamine H1-receptor agonists , histaprodifen , suprahistaprodifen , guinea-pig ileum , GTPase assay
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:10494
Owner only: item control page


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