Number of items at this level: 105.
2024
Scheuerer, Simon,
Motlova, Lucia,
Schäker-Hübner, Linda,
Sellmer, Andreas,
Feller, Felix,
Ertl, Fabian J.,
Koch, Pierre ,
Hansen, Finn K.,
Barinka, Cyril and
Mahboobi, Siavosh
(2024)
Biological and structural investigation of tetrahydro-β-carboline-based selective HDAC6 inhibitors with improved stability.
European Journal of Medicinal Chemistry 276, p. 116676.
2023
Nagl, Martin,
Moennich, Denise,
Rosier, Niklas ,
Schihada, Hannes,
Sirbu, Alexei,
Konar, Nergis,
Reyes-Resina, Irene,
Navarro, Gemma,
Franco, Rafael,
Kolb, Peter,
Annibale, Paolo and
Pockes, Steffen
(2023)
Fluorescent Tools for the Imaging of Dopamine D2‐Like Receptors.
ChemBioChem.
Rosier, Niklas ,
Moennich, Denise,
Nagl, Martin,
Schihada, Hannes,
Sirbu, Alexei,
Konar, Nergis,
Reyes-Resina, Irene,
Navarro, Gemma,
Franco, Rafael,
Kolb, Peter,
Annibale, Paolo and
Pockes, Steffen
(2023)
Shedding Light on the D1‐Like Receptors: A Fluorescence‐Based Toolbox for Visualization of the D1 and D5 Receptors.
ChemBioChem.
2022
Winkler, René ,
Mägdefrau, Ann-Sophie,
Piskor, Eva-Maria,
Kleemann, Markus,
Beyer, Mandy,
Linke, Kevin,
Hansen, Lisa,
Schaffer, Anna-Maria ,
Hoffmann, Marina E. ,
Poepsel, Simon ,
Heyd, Florian,
Beli, Petra,
Möröy, Tarik,
Mahboobi, Siavosh,
Krämer, Oliver H. and
Kosan, Christian
(2022)
Targeting the MYC interaction network in B-cell lymphoma via histone deacetylase 6 inhibition.
Oncogene 41 (40), pp. 4560-4572.
Singh, Gurpreet,
Liu, Peng,
Yao, Katherine R.,
Strasser, Jessica M.,
Hlynialuk, Chris,
Leinonen-Wright, Kailee,
Teravskis, Peter J.,
Choquette, Jessica M.,
Ikramuddin, Junaid,
Bresinsky, Merlin,
Nelson, Kathryn M.,
Liao, Dezhi,
Ashe, Karen H.,
Walters, Michael A. and
Pockes, Steffen
(2022)
Caspase-2 Inhibitor Blocks Tau Truncation and Restores Excitatory Neurotransmission in Neurons Modeling FTDP-17 Tauopathy.
ACS Chemical Neuroscience 13 (10), pp. 1549-1557.
Fulltext not available.
Beyer, Mandy,
Henninger, Sven J.,
Haehnel, Patricia S.,
Mustafa, Al-Hassan M. ,
Gurdal, Ece ,
Schubert, Bastian,
Christmann, Markus,
Sellmer, Andreas ,
Mahboobi, Siavosh,
Drube, Sebastian,
Sippl, Wolfgang,
Kindler, Thomas and
Krämer, Oliver H.
(2022)
Identification of a highly efficient dual type I/II FMS-like tyrosine kinase inhibitor that disrupts the growth of leukemic cells.
Cell Chemical Biology 29 (3), 398-411.e4.
Fulltext not available.
Szczepańska, Katarzyna,
Podlewska, Sabina,
Dichiara, Maria,
Gentile, Davide,
Patamia, Vincenzo,
Rosier, Niklas,
Mönnich, Denise,
Ruiz Cantero, Ma Carmen,
Karcz, Tadeusz,
Łażewska, Dorota,
Siwek, Agata,
Pockes, Steffen,
Cobos, Enrique J.,
Marrazzo, Agostino,
Stark, Holger,
Rescifina, Antonio,
Bojarski, Andrzej J.,
Amata, Emanuele and
Kieć-Kononowicz, Katarzyna
(2022)
Structural and Molecular Insight into Piperazine and Piperidine Derivatives as Histamine H3 and Sigma-1 Receptor Antagonists with Promising Antinociceptive Properties.
ACS Chemical Neuroscience 13 (1), pp. 1-15.
Fulltext not available.
2021
Wachholz, Vanessa,
Mustafa, Al-Hassan M.,
Zeyn, Yanira,
Henninger, Sven J.,
Beyer, Mandy,
Dzulko, Melanie,
Piée-Staffa, Andrea,
Brachetti, Christina,
Haehnel, Patricia S.,
Sellmer, Andreas,
Mahboobi, Siavosh,
Kindler, Thomas,
Brenner, Walburgis,
Nikolova, Teodora and
Krämer, Oliver H.
(2021)
Inhibitors of class I HDACs and of FLT3 combine synergistically against leukemia cells with mutant FLT3.
Archives of Toxicology 96 (1), pp. 177-193.
Grätz, Lukas,
Laasfeld, Tõnis,
Allikalt, Anni ,
Gruber, Corinna G.,
Pegoli, Andrea,
Tahk, Maris-Johanna,
Tsernant, Mari-Liis,
Keller, Max and
Rinken, Ago
(2021)
BRET- and fluorescence anisotropy-based assays for real-time monitoring of ligand binding to M2 muscarinic acetylcholine receptors.
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1868 (3), p. 118930.
Fulltext not available.
Gergs, Ulrich,
Büxel, Maren L.,
Bresinsky, Merlin,
Kirchhefer, Uwe,
Fehse, Charlotte,
Höring, Carina,
Hofmann, Britt,
Marušáková, Margaréta,
Čináková, Aneta,
Schwarz, Rebecca,
Pockes, Steffen and
Neumann, Joachim
(2021)
Cardiac Effects of Novel Histamine H2 Receptor Agonists.
Journal of Pharmacology and Experimental Therapeutics 379 (3), pp. 223-234.
Fulltext not available.
Szczepańska, Katarzyna ,
Pockes, Steffen ,
Podlewska, Sabina,
Höring, Carina,
Mika, Kamil,
Latacz, Gniewomir,
Bednarski, Marek,
Siwek, Agata ,
Karcz, Tadeusz,
Nagl, Martin,
Bresinsky, Merlin,
Mönnich, Denise,
Seibel, Ulla,
Kuder, Kamil J. ,
Kotańska, Magdalena,
Stark, Holger,
Elz, Sigurd and
Kieć-Kononowicz, Katarzyna
(2021)
Structural modifications in the distal, regulatory region of histamine H3 receptor antagonists leading to the identification of a potent anti-obesity agent.
European Journal of Medicinal Chemistry 213, p. 113041.
Fulltext not available.
2020
Grätz, Lukas,
Tropmann, Katharina,
Bresinsky, Merlin,
Müller, Christoph,
Bernhardt, Günther and
Pockes, Steffen
(2020)
NanoBRET binding assay for histamine H2 receptor ligands using live recombinant HEK293T cells.
Scientific Reports 10, p. 13288.
Sellmer, Andreas,
Pilsl, Bernadette,
Beyer, Mandy,
Pongratz, Herwig,
Wirth, Lukas,
Elz, Sigurd,
Dove, Stefan,
Henninger, Sven Julian,
Spiekermann, Karsten,
Polzer, Harald,
Klaeger, Susan,
Kuster, Bernhard,
Böhmer, Frank D.,
Fiebig, Heinz-Herbert,
Krämer, Oliver H. and
Mahboobi, Siavosh
(2020)
A series of novel aryl-methanone derivatives as inhibitors of FMS-like tyrosine kinase 3 (FLT3) in FLT3-ITD-positive acute myeloid leukemia.
European Journal of Medicinal Chemistry 193, p. 112232.
Fulltext not available.
Schihada, Hannes ,
Ma, Xiaoyuan,
Zabel, Ulrike,
Vischer, Henry F.,
Schulte, Gunnar ,
Leurs, Rob,
Pockes, Steffen and
Lohse, Martin J.
(2020)
Development of a Conformational Histamine H3 Receptor Biosensor for the Synchronous Screening of Agonists and Inverse Agonists.
ACS Sensors 5 (6), pp. 1734-1742.
Fulltext not available.
2019
2018
Pockes, Steffen ,
Wifling, David ,
Keller, Max,
Buschauer, Armin and
Elz, Sigurd
(2018)
Highly Potent, Stable, and Selective Dimeric Hetarylpropylguanidine-Type Histamine H2 Receptor Agonists.
ACS Omega 2018 (3), pp. 2865-2882.
Leonhardt, Michel,
Sellmer, Andreas ,
Krämer, Oliver H.,
Dove, Stefan,
Elz, Sigurd,
Kraus, Birgit,
Beyer, Mandy and
Mahboobi, Siavosh
(2018)
Design and biological evaluation of tetrahydro-β-carboline derivatives as highly potent histone deacetylase 6 (HDAC6) inhibitors.
European Journal of Medicinal Chemistry 152, pp. 329-357.
Fulltext not available.
Ridinger, Johannes,
Koeneke, Emily,
Kolbinger, Fiona R.,
Koerholz, Katharina,
Mahboobi, Siavosh,
Hellweg, Lars,
Gunkel, Nikolas,
Miller, Aubry K.,
Peterziel, Heike,
Schmezer, Peter,
Hamacher-Brady, Anne ,
Witt, Olaf and
Oehme, Ina
(2018)
Dual role of HDAC10 in lysosomal exocytosis and DNA repair promotes neuroblastoma chemoresistance.
Scientific Reports 8 (1).
Fulltext not available.
Pons, Miriam,
make_name_string expected hash reference,
make_name_string expected hash reference,
make_name_string expected hash reference,
make_name_string expected hash reference ,
make_name_string expected hash reference,
make_name_string expected hash reference,
make_name_string expected hash reference,
make_name_string expected hash reference,
make_name_string expected hash reference and
make_name_string expected hash reference
(2018)
Human platelet lysate as validated replacement for animal serum to assess chemosensitivity.
ALTEX.
Fulltext not available.
2017
Stojanovic, N.,
Hassan, Z.,
Wirth, M.,
Wenzel, P.,
Beyer, M.,
Schäfer, C.,
Brand, P.,
Kroemer, A.,
Stauber, R. H.,
Schmid, R. M.,
Arlt, A.,
Sellmer, A.,
Mahboobi, S.,
Rad, R.,
Reichert, M.,
Saur, D.,
Krämer, O. H. and
Schneider, G.
(2017)
HDAC1 and HDAC2 integrate the expression of p53 mutants in pancreatic cancer.
Oncogene 36 (13), pp. 1804-1815.
Fulltext not available.
Tsitsipatis, Dimitrios,
Jayavelu, Ashok Kumar,
Müller, Jörg P.,
Bauer, Reinhard,
Schmidt-Arras, Dirk,
Mahboobi, Siavosh,
Schnöder, Tina M.,
Heidel, Florian and
Böhmer, Frank D.
(2017)
Synergistic killing of FLT3ITD-positive AML cells by combined inhibition of tyrosine-kinase activity and N-glycosylation.
Oncotarget 8 (16).
Fulltext not available.
2016
Naporra, Franziska,
Gobleder, Susanne,
Wittmann, Hans-Joachim,
Spindler, Julia,
Bodensteiner, Michael,
Bernhardt, Günther,
Hübner, Harald,
Gmeiner, Peter,
Elz, Sigurd and
Strasser, Andrea
(2016)
Dibenzo[b,f][1,4]oxazepines and dibenzo[b,e]oxepines: Influence of the chlorine substitution pattern on the pharmacology at the H1R, H4R, 5-HT2AR and other selected GPCRs.
Pharmacological Research 113, pp. 610-625.
(In Press)
Fulltext not available.
Hammer, Sebastian,
Gobleder, Susanne,
Naporra, Franziska,
Wittmann, Hans-Joachim,
Elz, Sigurd,
Heinrich, Markus and
Strasser, Andrea
(2016)
2,4-Diaminopyrimidines as dual ligands at the histamine H1 and H4 receptor - H1/H4-receptor selectivity.
Bioorganic & Medicinal Chemistry Letters 26, pp. 292-300.
Fulltext not available.
Naporra, Franziska,
Gobleder, Susanne,
Wittmann, Hans-Joachim,
Spindler, Julia,
Bodensteiner, Michael,
Bernhardt, Günther,
Hübner, Harald,
Gmeiner, Peter ,
Elz, Sigurd and
Strasser, Andrea
(2016)
Dibenzo[ b , f ][1,4]oxazepines and dibenzo[ b , e ]oxepines: Influence of the chlorine substitution pattern on the pharmacology at the H 1 R, H 4 R, 5-HT 2A R and other selected GPCRs.
Pharmacological Research 113, pp. 610-625.
Fulltext not available.
2015
Baumeister, Paul,
Erdmann, Daniela,
Biselli, Sabrina,
Kagermeier, Nicole,
Elz, Sigurd,
Bernhardt, Günther and
Buschauer, Armin
(2015)
3HUR-DE257: Development of a tritium-labeled squaramide-type selective histamine H2 receptor antagonist.
ChemMedChem 10 (1), pp. 83-93.
Fulltext not available.
2014
Darras, Fouad,
Pockes, Steffen ,
Huang, Guozheng,
Wehle, Sarah,
Strasser, Andrea,
Wittmann, Hans-Joachim,
Nimczick, Martin,
Sotriffer, Christoph and
Decker, Michael
(2014)
Synthesis, biological evaluation, and computational studies of tri- and tetracyclic nitrogen-bridgehead compounds as potent dual-acting AChE inhibitors and hH3 receptor antagonists.
ACS Chemical Neuroscience 5 (3), pp. 225-242.
Fulltext not available.
Geyer, Roland,
Igel, Patrick,
Kaske, Melanie,
Elz, Sigurd and
Buschauer, Armin
(2014)
Synthesis, SAR and selectivity of 2-acyl- and 2-cyano-1-hetarylalkyl-guanidines at the four histamine receptor subtypes: a bioisosteric approach.
MedChemComm 5 (1), pp. 72-81.
Fulltext not available.
2013
2012
Birnkammer, Tobias,
Spickenreither, Anja,
Brunskole, Irena,
Lopuch, Miroslaw,
Kagermeier, Nicole,
Bernhardt, Günther,
Dove, Stefan,
Seifert, Roland,
Elz, Sigurd and
Buschauer, Armin
(2012)
The bivalent ligand approach leads to highly potent and selective acylguanidine-type histamine H2 receptor agonists.
Journal of Medicinal Chemistry 55 (3), pp. 1147-1160.
Fulltext not available.
2011
2010
Ghorai, Prasanta,
Kraus, Anja,
Birnkammer, Tobias,
Geyer, Roland,
Bernhardt, Günther,
Dove, Stefan,
Seifert, Roland,
Elz, Sigurd and
Buschauer, Armin
(2010)
Chiral N(G)-acylated hetarylpropylguanidine-type histamine H2 receptor agonists do not show significant stereoselectivity.
Bioorganic & Medicinal Chemistry Letters 20 (10), pp. 3173-3176.
Fulltext not available.
2009
Igel, Patrick,
Schneider, Erich,
Schnell, David,
Elz, Sigurd,
Seifert, Roland and
Buschauer, Armin
(2009)
N(G)-Acylated imidazolylpropylguanidines as potent histamine H4 receptor agonists: selectivity by variation of the N(G)-substituent.
Journal of Medicinal Chemistry 52 (8), pp. 2623-2627.
Fulltext not available.
Kraus, Anja,
Ghorai, Prasanta,
Birnkammer, Tobias,
Schnell, David,
Elz, Sigurd,
Seifert, Roland,
Dove, Stefan,
Bernhardt, Günther and
Buschauer, Armin
(2009)
N(G)-Acylated aminothiazolylpropylguanidines as potent and selective histamine H2 receptor agonists.
ChemMedChem 4 (2), pp. 232-240.
Fulltext not available.
Mahboobi, Siavosh,
Dove, Stefan,
Sellmer, Andreas,
Winkler, Matthias,
Eichhorn, Emerich,
Pongratz, Herwig,
Ciossek, Thomas,
Baer, Thomas,
Maier, Thomas and
Beckers, Thomas
(2009)
Design of chimeric histone deacetylase- and tyrosine kinase-inhibitors: a series of imatinib hybrides as potent inhibitors of wild-type and mutant BCR-ABL, PDGF-Rbeta, and histone deacetylases.
Journal of medicinal chemistry 52 (8), pp. 2265-79.
Fulltext not available.
2008
Ghorai, Prasanta,
Kraus, Anja,
Keller, Max,
Götte, Carsten,
Igel, Patrick,
Schneider, Erich,
Schnell, David,
Bernhardt, Günther,
Dove, Stefan,
Zabel, Manfred,
Elz, Sigurd,
Seifert, Roland and
Buschauer, Armin
(2008)
Acylguanidines as bioisosteres of guanidines: N(G)-acylated imidazolylpropylguanidines, a new class of histamine H2 receptor agonists.
Journal of Medicinal Chemistry 51 (22), pp. 7193-7204.
Fulltext not available.
Mahboobi, Siavosh,
Sellmer, Andreas,
Eswayah, Asma,
Elz, Sigurd,
Uecker, Andrea and
Böhmer, Frank-D.
(2008)
Inhibition of PDGFR tyrosine kinase activity by a series of novel N-(3-(4-(pyridin-3-yl)-1H-imidazol-2-ylamino)phenyl)amides: a SAR study on the bioisosterism of pyrimidine and imidazole.
European journal of medicinal chemistry 43 (7), pp. 1444-1453.
Fulltext not available.
2007
Mahboobi, Siavosh,
Uecker, A.,
Cénac, C.,
Sellmer, A.,
Eichhorn, E.,
Elz, Sigurd,
Böhmer, F.-D. and
Dove, Stefan
(2007)
Inhibition of FLT3 and PDGFR tyrosine kinase activity by bis(benzo[b]furan-2-yl)methanones.
Bioorganic & medicinal chemistry 15 (5), pp. 2187-2197.
Fulltext not available.
2006
Xie, Sheng-Xue,
Kraus, Anja,
Ghorai, Prasanta,
Ye, Qi-Zhuang,
Elz, Sigurd,
Buschauer, Armin and
Seifert, Roland
(2006)
N1-(3-Cyclohexylbutanoyl)-N2-[3-(1H-imidazol-4-
yl)propyl]guanidine (UR-AK57), a Potent Partial Agonist for the Human Histamine H1- and H2- Receptors.
Journal of Pharmacology and Experimental Therapeutics 317 (3), pp. 1262-1268.
Fulltext restricted.
Mahboobi, Siavosh,
Uecker, A.,
Sellmer, A.,
Cénac, C.,
Höcher, H.,
Pongratz, H.,
Hufsky, H.,
Trümpler, A.,
Sicker, M.,
Heidel, F.,
Fischer, T.,
Stocking, C.,
Elz, Sigurd,
Böhmer, F.-D. and
Dove, Stefan
(2006)
Novel bis-(1H-indol-2-yl)-methanones as potent inhibitors of FLT3 and platelet-derived growth factor receptor tyrosine kinase.
Journal of Medicinal Chemistry 49 (11), pp. 3101-3115.
Fulltext not available.
2005
2004
2003
Li, Liantao,
Kracht, Julia,
Peng, Shiqi,
Bernhardt, Günther,
Elz, Sigurd and
Buschauer, Armin
(2003)
Synthesis and pharmacological activity of fluorescent histamine H2 receptor antagonists related to potentidine,.
Bioorganic & Medicinal Chemistry Letters 13 (10), 0960-894.
Fulltext not available.
Böhmer, F. D.,
Karagyozov, L.,
Uecker, A.,
Serve, H.,
Botzki, A.,
Mahboobi, Siavosh and
Dove, Stefan
(2003)
A single amino acid exchange inverts susceptibility of related receptor tyrosine kinases for the ATP-site inhibitor STI-571.
The Journal of Biological Chemistry 278 (7), pp. 5148-5155.
Fulltext not available.
Seifert, Roland,
Wenzel-Seifert, Katharina,
Bürckstümmer, Tilmann,
Pertz, Heinz H.,
Schunack, Walter,
Dove, Stefan,
Buschauer, Armin and
Elz, Sigurd
(2003)
Multiple differences in agonist and antagonist pharmacology between human and guinea pig histamine H1-receptor,.
Journal of Pharmacology and Experimental Therapeutics 305, pp. 1104-1115.
Fulltext not available.
2002
Mahboobi, Siavosh,
Teller, S.,
Pongratz, H.,
Hufsky, H.,
Sellmer, A.,
Botzki, Alexander,
Uecker, A.,
Beckers, T.,
Baasner, S.,
Schächtele, C.,
Überall, F.,
Kassack, M. U.,
Dove, Stefan and
Böhmer, F.-D.
(2002)
Bis(1H-2-indolyl)methanones as a novel class of inhibitors of the platelet-derived growth factor receptor kinase.
Journal of Medicinal Chemistry 45 (5), pp. 1002-1018.
Fulltext not available.
1999
1998
Mayer, Klaus K.,
Dove, Stefan,
Pongratz, Herwig,
Ertan, M. and
Wiegrebe, Wolfgang
(1998)
Electron impact induced fragmentation of 4-aryl-4,6,7,8-tetrahydro-1H,3H-quinazolinone-2,5-diones.
Heterocycles 48 (6), pp. 1169-1183.
Fulltext not available.
1997
Mahboobi, Siavosh,
Dove, Stefan,
Bednarski, P. J.,
Kuhr, S.,
Burgemeister, Thomas and
Schollmeyer, D.
(1997)
X-Ray Crystal Structure of Woodinine and Conformational Analysis by Means of Semiempirical and 1H-NMR Methods.
Journal of Natural Products-Copublished with the Am. Soc. of Pharmacognosy 60 (6), pp. 587-591.
Fulltext not available.
1994
1993
1992
Hirschfeld, Jürgen,
Buschauer, Armin,
Elz, Sigurd,
Schunack, Walter,
Ruat, Martial,
Traiffort, Elisabeth and
Schwartz, Jean-Charles
(1992)
Iodoaminopotentidine and related compounds: a new class of ligands with high affinity and selectivity for the histamine H_2-receptor.
Journal of Medicinal Chemistry 35, pp. 2231-2238.
Fulltext not available.
1988
1987
1986
Buschauer, Armin,
Schickaneder, Helmut,
Elz, Sigurd,
Schunack, Walter,
Szelenyi, Istvan,
Baumann, Gert and
Ahrens, K.-H.
(1986)
Guanidinderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel.
Patentanmeldung P 35 12 084.3 (2.4.1985), Offenlegungsschrift DE 35 12 084 A.
Fulltext not available.
1985
Schunack, Walter,
Buschauer, Armin,
Büyüktimkim, Servet,
Dziuron, Peter,
Elz, Sigurd,
Gerhardt, Günter,
Lebenstedt, Ernst,
Lennartz, Hans-Gerd,
Schwarz, Siegfried,
Spitzhoff, Margrit and
Steffens, Robert
(1985)
2. Histamine agonists - chemistry and structure-activity relationships.
In:
Dahlbom, R. and
Nilsson, J. L. G., (eds.)
VIIIth International Symposium on Medicinal Chemistry.
Swedish Pharmaceutical Press, Stockholm, pp. 169-182.
Fulltext not available.
Buschauer, Armin,
Schickaneder, Helmut,
Schunack, Walter,
Elz, Sigurd,
Szelenyi, Istvan,
Baumann, Gert and
Ahrens, K.-H.
(1985)
Imidazolylalkylguanidine, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel.
Patentanmeldung 85 114 205.9 (12.11.1985), Eur. Pat. Appl. EP 0 199 845 (5.11.1986).
Fulltext not available.
1984
1983
Elz, Sigurd,
Buschauer, Armin,
Dräger, M. and
Schunack, Walter
(1983)
Darstellung, Eigenschaften und Kristallstruktur der N-[2-(4,5,6,7-Tetrahydro-2-benzimidazolyl)ethyl]phthalamidsäure.
Z. Naturforsch. 38b, pp. 1203-1207.
Fulltext not available.
This list was generated on Sat Oct 12 08:04:37 2024 CEST.