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Number of items at this level: 73.

2019

Grünstein, Elisabeth (2019) Selektive HDAC6-Inhibitoren: Synthese und biologische Testung. PhD, Universität Regensburg.

2018

Pockes, Steffen, Wifling, David, Keller, Max, Buschauer, Armin and Elz, Sigurd (2018) Highly Potent, Stable, and Selective Dimeric Hetarylpropylguanidine-Type Histamine H2 Receptor Agonists. ACS Omega 2018 (3), pp. 2865-2882.

Pockes, Steffen (2018) Synthese und pharmakologische Charakterisierung von Heteroarylpropylguanidin-Derivaten an Histamin-Rezeptorsubtypen: Struktur-Wirkungsbeziehungen mono- und bivalenter Liganden. PhD, Universität Regensburg.

Wiesneth, Stefan, Aas, Gregor, Heilmann, Jörg and Jürgenliemk, Guido (2018) Investigation of the flavan-3-ol patterns in willow species during one growing-season. Phytochemistry 145, pp. 26-39. Fulltext not available.

2017

Stojanovic, N, Hassan, Z, Wirth, M, Wenzel, P, Beyer, M, Schäfer, C, Brand, P, Kroemer, A, Stauber, R H, Schmid, R M, Arlt, A, Sellmer, A, Mahboobi, S, Rad, R, Reichert, M, Saur, D, Krämer, O H and Schneider, G (2017) HDAC1 and HDAC2 integrate the expression of p53 mutants in pancreatic cancer. Oncogene 36 (13), pp. 1804-1815. Fulltext not available.

Tsitsipatis, Dimitrios, Jayavelu, Ashok Kumar, Müller, Jörg P., Bauer, Reinhard, Schmidt-Arras, Dirk, Mahboobi, Siavosh, Schnöder, Tina M., Heidel, Florian and Böhmer, Frank D. (2017) Synergistic killing of FLT3ITD-positive AML cells by combined inhibition of tyrosine-kinase activity and N-glycosylation. Oncotarget 8 (16). Fulltext not available.

2016

Lieb, Sebastian, Littmann, Timo, Plank, Nicole, Felixberger, Johannes, Tanaka, Miho, Schäfer, Thorsten, Krief, Stéphane, Elz, Sigurd, Friedland, Kristina, Bernhardt, Günther, Wegener, Joachim, Ozawa, Takeaki and Buschauer, Armin (2016) Label-free versus conventional cellular assays: functional investigations on the human histamine H1 receptor. Pharmacological Research 114, pp. 13-26. Fulltext not available.

Naporra, Franziska, Gobleder, Susanne, Wittmann, Hans-Joachim, Spindler, Julia, Bodensteiner, Michael, Bernhardt, Günther, Hübner, Harald, Gmeiner, Peter, Elz, Sigurd and Strasser, Andrea (2016) Dibenzo[b,f][1,4]oxazepines and dibenzo[b,e]oxepines: Influence of the chlorine substitution pattern on the pharmacology at the H1R, H4R, 5-HT2AR and other selected GPCRs. Pharmacological Research 113, pp. 610-625. (In Press) Fulltext not available.

Gobleder, Susanne (2016) Synthesis and pharmacological characterization of new histamine H1-/H4-receptor ligands derived from the atypical antipsychotic drug Clozapine. PhD, Universität Regensburg.

Hammer, Sebastian, Gobleder, Susanne, Naporra, Franziska, Wittmann, Hans-Joachim, Elz, Sigurd, Heinrich, Markus and Strasser, Andrea (2016) 2,4-Diaminopyrimidines as dual ligands at the histamine H1 and H4 receptor - H1/H4-receptor selectivity. Bioorganic & Medicinal Chemistry Letters 26, pp. 292-300. Fulltext not available.

2015

Helm, Klaus (2015) Synthese und funktionelle In-vitro-Pharmakologie neuer Liganden des 5-HT2A-Rezeptors aus der Klasse der Tryptamine. PhD, Universität Regensburg.

Baumeister, Paul, Erdmann, Daniela, Biselli, Sabrina, Kagermeier, Nicole, Elz, Sigurd, Bernhardt, Günther and Buschauer, Armin (2015) 3HUR-DE257: Development of a tritium-labeled squaramide-type selective histamine H2 receptor antagonist. ChemMedChem 10 (1), pp. 83-93. Fulltext not available.

Wiesneth, Stefan, Petereit, Frank and Jürgenliemk, Guido (2015) Salix daphnoides: A Screening for Oligomeric and Polymeric Proanthocyanidins. Molecules 20 (8), pp. 13764-13779.

2014

Geyer, Roland, Igel, Patrick, Kaske, Melanie, Elz, Sigurd and Buschauer, Armin (2014) Synthesis, SAR and selectivity of 2-acyl- and 2-cyano-1-hetarylalkyl-guanidines at the four histamine receptor subtypes: a bioisosteric approach. MedChemComm 5 (1), pp. 72-81. Fulltext not available.

Darras, Fouad, Pockes, Steffen, Huang, Guozheng, Wehle, Sarah, Strasser, Andrea, Wittmann, Hans-Joachim, Nimczick, Martin, Sotriffer, Christoph and Decker, Michael (2014) Synthesis, biological evaluation, and computational studies of tri- and tetracyclic nitrogen-bridgehead compounds as potent dual-acting AChE inhibitors and hH3 receptor antagonists. ACS Chemical Neuroscience 5, pp. 225-242. Fulltext not available.

2013

Sadek, Bassem, Alisch, Rudi, Buschauer, Armin and Elz, Sigurd (2013) Synthesis and dual histamine H1 and H2 receptor antagonist activity of cyanoguanidine derivatives. Molecules 18 (11), pp. 14186-14202.

2012

Eswayah, Asma Mohamed (2012) Neue Imidazol- und Indolderivate -
Synthese und biologische in-vitro-Prüfungen.
PhD, Universität Regensburg.

Birnkammer, Tobias, Spickenreither, Anja, Brunskole, Irena, Lopuch, Miroslaw, Kagermeier, Nicole, Bernhardt, Günther, Dove, Stefan, Seifert, Roland, Elz, Sigurd and Buschauer, Armin (2012) The bivalent ligand approach leads to highly potent and selective acylguanidine-type histamine H2 receptor agonists. Journal of Medicinal Chemistry 55 (3), pp. 1147-1160. Fulltext not available.

Strasser, Andrea and Wittmann, Hans-Joachim (2012) Binding of Ligands to GPCRs – How Valid is a Thermodynamic
Discrimination of Antagonists and Agonists?
Journal of Physical Chemistry & Biophysics 2012.

2011

Silva, Maria Elena, Heim, Ralf, Strasser, Andrea, Elz, Sigurd and Dove, Stefan (2011) Theoretical studies on the interaction of partial agonists with the 5-HT(2A) receptor. Journal of computer-aided molecular design 25 (1), pp. 51-66. Fulltext not available.

Wittmann, Hans-Joachim, Elz, Sigurd, Seifert, Roland and Strasser, Andrea (2011) Na-methylated phenylhistamines exhibit affinity to the hH4R - a pharmacological and molecular modelling study. Naunyn Schmiedeberg's Arch Pharmacol 384, pp. 287-299. Fulltext not available.

2010

Ghorai, Prasanta, Kraus, Anja, Birnkammer, Tobias, Geyer, Roland, Bernhardt, Günther, Dove, Stefan, Seifert, Roland, Elz, Sigurd and Buschauer, Armin (2010) Chiral N(G)-acylated hetarylpropylguanidine-type histamine H2 receptor agonists do not show significant stereoselectivity. Bioorganic & Medicinal Chemistry Letters 20 (10), pp. 3173-3176. Fulltext not available.

Matzdorf, Thorsten (2010) 5-Carboxamidotryptamin-Derivate als Liganden für 5-HT7- und 5-HT2A-Rezeptoren: Synthese und In-vitro-Pharmakologie. PhD, Universität Regensburg.

Schneider, Erich H., Schnell, David, Strasser, Andrea, Dove, Stefan and Seifert, Roland (2010) Impact of the DRY Motif and the Missing "Ionic Lock" on Constitutive Activity and G-Protein Coupling of the Human Histamine H-4 Receptor. Journal of Pharmacology and Experimental Therapeutics 333 (2), pp. 382-392. Fulltext not available.

2009

Prainer, Bianca-Cristine (2009) Tryptamin-Derivate als 5-HT4-Rezeptorliganden: Synthese und in-vitro-Pharmakologie. PhD, Universität Regensburg.

Jenning, Stefan (2009) Ondansetron-analoge 5-HT3-Rezeptorliganden: Synthese, Stereochemie und in-vitro-Pharmakologie. PhD, Universität Regensburg.

Igel, Patrick, Schneider, Erich, Schnell, David, Elz, Sigurd, Seifert, Roland and Buschauer, Armin (2009) N(G)-Acylated imidazolylpropylguanidines as potent histamine H4 receptor agonists: selectivity by variation of the N(G)-substituent. Journal of Medicinal Chemistry 52 (8), pp. 2623-2627. Fulltext not available.

Kraus, Anja, Ghorai, Prasanta, Birnkammer, Tobias, Schnell, David, Elz, Sigurd, Seifert, Roland, Dove, Stefan, Bernhardt, Günther and Buschauer, Armin (2009) N(G)-Acylated aminothiazolylpropylguanidines as potent and selective histamine H2 receptor agonists. ChemMedChem 4 (2), pp. 232-240. Fulltext not available.

Mahboobi, Siavosh, Dove, Stefan, Sellmer, Andreas, Winkler, Matthias, Eichhorn, Emerich, Pongratz, Herwig, Ciossek, Thomas, Baer, Thomas, Maier, Thomas and Beckers, Thomas (2009) Design of chimeric histone deacetylase- and tyrosine kinase-inhibitors: a series of imatinib hybrides as potent inhibitors of wild-type and mutant BCR-ABL, PDGF-Rbeta, and histone deacetylases. Journal of medicinal chemistry 52 (8), pp. 2265-79. Fulltext not available.

Strasser, Andrea, Wittmann, Hans-Joachim, Kunze, Marc, Elz, Sigurd and Seifert, Roland (2009) Molecular basis for the selective interaction of synthetic agonists with the human histamine H1-receptor compared with the guinea-pig H1-receptor. Mol Pharmacol : Molecular pharmacology 75, pp. 454-465. Fulltext not available.

2008

Ghorai, Prasanta, Kraus, Anja, Keller, Max, Götte, Carsten, Igel, Patrick, Schneider, Erich, Schnell, David, Bernhardt, Günther, Dove, Stefan, Zabel, Manfred, Elz, Sigurd, Seifert, Roland and Buschauer, Armin (2008) Acylguanidines as bioisosteres of guanidines: N(G)-acylated imidazolylpropylguanidines, a new class of histamine H2 receptor agonists. Journal of Medicinal Chemistry 51 (22), pp. 7193-7204. Fulltext not available.

Schumacher, Matthias (2008) Chirale Arylmethoxytryptamine als 5-HT2B-Rezeptoragonisten: Synthese, Analytik und in-vitro-Pharmakologie. PhD, Universität Regensburg.

Strasser, Andrea, Striegl, Birgit, Wittmann, Hans-Joachim and Seifert, Roland (2008) Pharmacological Profile of Histaprodifens at Four Recombinant Histamine H1 Receptor Species Isoforms. Journal of Pharmacology and Experimental Therapeutics 324, pp. 60-71. Fulltext not available.

Dove, Stefan, Seifert, Roland, Elz, Sigurd and Buschauer, Armin (2008) Frontiers in medicinal chemistry in Regensburg. ChemMedChem 3 (8), pp. 1181-1184. Fulltext not available.

Mahboobi, Siavosh, Sellmer, Andreas, Eswayah, Asma, Elz, Sigurd, Uecker, Andrea and Böhmer, Frank-D. (2008) Inhibition of PDGFR tyrosine kinase activity by a series of novel N-(3-(4-(pyridin-3-yl)-1H-imidazol-2-ylamino)phenyl)amides: a SAR study on the bioisosterism of pyrimidine and imidazole. European journal of medicinal chemistry 43 (7), pp. 1444-1453. Fulltext not available.

2007

Kunze, Marc (2007) Histamin-H1-Rezeptoragonisten vom Suprahistaprodifen- und 2-Phenylhistamin-Typ und 2-substituierte Imidazolylpropan-Derivate als Liganden für H1/H2/H3/H4-Rezeptoren. Neue Synthesestrategien und pharmakologische Testung. PhD, Universität Regensburg.

Walbrun, Peter (2007) Repopulation genetisch veränderter Kupffer-Zellen und Evaluation deren Effekte in einem akuten hepatischen Schädigungsmodell. PhD, Universität Regensburg.

Striegl, Birgit (2007) Synthese und funktionelle in-vitro-Pharmakologie neuer Histamin-H1-Rezeptoragonisten aus der Suprahistaprodifen-Reihe. PhD, Universität Regensburg.

Mahboobi, Siavosh, Uecker, A., Cénac, C., Sellmer, A., Eichhorn, E., Elz, Sigurd, Böhmer, F.-D. and Dove, Stefan (2007) Inhibition of FLT3 and PDGFR tyrosine kinase activity by bis(benzo[b]furan-2-yl)methanones. Bioorganic & medicinal chemistry 15 (5), pp. 2187-2197. Fulltext not available.

2006

Bäumel, Monika (2006) Funktionelle Charakterisierung von p75TNF-Rezeptor-Isoformen. PhD, Universität Regensburg.

Xie, Sheng-Xue, Kraus, Anja, Ghorai, Prasanta, Ye, Qi-Zhuang, Elz, Sigurd, Buschauer, Armin and Seifert, Roland (2006) N1-(3-Cyclohexylbutanoyl)-N2-[3-(1H-imidazol-4-
yl)propyl]guanidine (UR-AK57), a Potent Partial Agonist for the Human Histamine H1- and H2- Receptors.
Journal of Pharmacology and Experimental Therapeutics 317 (3), pp. 1262-1268. Fulltext restricted.

Mahboobi, Siavosh, Uecker, A., Sellmer, A., Cénac, C., Höcher, H., Pongratz, H., Hufsky, H., Trümpler, A., Sicker, M., Heidel, F., Fischer, T., Stocking, C., Elz, Sigurd, Böhmer, F.-D. and Dove, Stefan (2006) Novel bis-(1H-indol-2-yl)-methanones as potent inhibitors of FLT3 and platelet-derived growth factor receptor tyrosine kinase. Journal of Medicinal Chemistry 49 (11), pp. 3101-3115. Fulltext not available.

2005

Sterns, Theobald (2005) Serum-Zytokinspiegel und Empfindlichkeit für Super-Infektionen im Maus-Sepsismodell. PhD, Universität Regensburg.

Scherübl, Christoph (2005) Charakterisierung einer neuen Isoform des humanen p75TNF-Rezeptors. PhD, Universität Regensburg.

2004

Dove, Stefan, Elz, Sigurd, Seifert, Roland and Buschauer, Armin (2004) Structure-Activity Relationships of Histamine H_2 Receptor Ligands,. Mini-Rev. Med. Chem. 4 (9), pp. 941-954. Fulltext not available.

2003

Li, Liantao, Kracht, Julia, Peng, Shiqi, Bernhardt, Günther, Elz, Sigurd and Buschauer, Armin (2003) Synthesis and pharmacological activity of fluorescent histamine H2 receptor antagonists related to potentidine,. Bioorganic & Medicinal Chemistry Letters 13 (10), 0960-894. Fulltext not available.

Böhmer, F.D., Karagyozov, L., Uecker, A., Serve, H., Botzki, A., Mahboobi, Siavosh and Dove, Stefan (2003) A single amino acid exchange inverts susceptibility of related receptor tyrosine kinases for the ATP-site inhibitor STI-571. The Journal of Biological Chemistry 278 (7), pp. 5148-5155. Fulltext not available.

Seifert, Roland, Wenzel-Seifert, Katharina, Bürckstümmer, Tilmann, Pertz, Heinz H., Schunack, Walter, Dove, Stefan, Buschauer, Armin and Elz, Sigurd (2003) Multiple differences in agonist and antagonist pharmacology between human and guinea pig histamine H1-receptor,. Journal of Pharmacology and Experimental Therapeutics 305, pp. 1104-1115. Fulltext not available.

2002

Mahboobi, Siavosh, Teller, S., Pongratz, H., Hufsky, H., Sellmer, A., Botzki, Alexander, Uecker, A., Beckers, T., Baasner, S., Schächtele, C., Überall, F., Kassack, M. U., Dove, Stefan and Böhmer, F.-D. (2002) Bis(1H-2-indolyl)methanones as a novel class of inhibitors of the platelet-derived growth factor receptor kinase. Journal of Medicinal Chemistry 45 (5), pp. 1002-1018. Fulltext not available.

1999

Mahboobi, Siavosh, Dove, Stefan, Kuhr, S. and Popp, A. (1999) Homo-arcyriaflavin: The synthesis of ring-expanded arcyriaflavin analogs. The Journal of Organic Chemistry 64 (22), pp. 8130-8137. Fulltext not available.

Mahboobi, Siavosh, Dove, Stefan, Kuhr, S. and Pongratz, Hewig (1999) Synthesis of arcyriarubine regioisomers by Pd(0)-catalysis or via lithiated indole derivatives - conformational analysis by semiempirical and X-ray methods. Pharmazie 54 (11), pp. 820-827. Fulltext not available.

1998

Mayer, Klaus K., Dove, Stefan, Pongratz, Herwig, Ertan, M. and Wiegrebe, Wolfgang (1998) Electron impact induced fragmentation of 4-aryl-4,6,7,8-tetrahydro-1H,3H-quinazolinone-2,5-diones. Heterocycles 48 (6), pp. 1169-1183. Fulltext not available.

1997

Mahboobi, Siavosh, Dove, Stefan, Bednarski, P. J., Kuhr, S., Burgemeister, Thomas and Schollmeyer, D. (1997) X-Ray Crystal Structure of Woodinine and Conformational Analysis by Means of Semiempirical and 1H-NMR Methods. Journal of Natural Products-Copublished with the Am. Soc. of Pharmacognosy 60 (6), pp. 587-591. Fulltext not available.

1994

Monti, J. M., Jantos, H., Leschke, C., Elz, Sigurd and Schunack, W. (1994) The selective histamine H1-receptor agonist 2-(3-trifluoromethylphenyl)histamine increases waking in the rat. European neuropsychopharmacology 4 (4), pp. 459-462. Fulltext not available.

Lowe, W., Elz, Sigurd, Reiser, H. and Schott, S. (1994) [7-fluoro-4-chromone-3-sulfur compounds]. Archiv der Pharmazie 327 (4), pp. 267-269. Fulltext not available.

1993

Zingel, V., Elz, Sigurd and Schunack, W. (1993) Histamine analogues, XXXV: 2-substituted histamine derivatives containing classical moieties of H2-antagonists--a novel class of H1-agonists. Archiv der Pharmazie 326 (3), pp. 143-151. Fulltext not available.

Radwansky, A., Elz, Sigurd and Lehmann, J. (1993) Lactones, XXY: Synthesis and 5-HT2-receptor affinity of some fluorophenylated alpha-aminomethyllactones. Archiv der Pharmazie 326 (4), pp. 243-244. Fulltext not available.

Elz, Sigurd, Zimmermann, H. and Rehse, K. (1993) Selectivity of sterically fixed tryptamine and 5-methoxytryptamine derivatives for serotonin receptor subtypes, II: Structure-activity relationships and in vitro pharmacology of N-alkyl- and N,N-dialkyl-3- indolylbicyclo-[2.2.1]-heptane-2-amines. Archiv der Pharmazie 326 (11), pp. 893-899. Fulltext not available.

1992

Zingel, V., Elz, Sigurd and Schunack, W. (1992) Histamine analogues. 36th communication. Basically substituted histamine derivatives with H1-agonistic activity. Pharmazie 47 (10), pp. 746-751. Fulltext not available.

Sellier, Christian, Elz, Sigurd, Buschauer, Armin and Schunack, Walter (1992) Histamine analogues: imidazolylalkylguanidines, synthesis and in vitro pharmacology. European Journal of Medicinal Chemistry 27, pp. 27-32. Fulltext not available.

Seifert, Roland, Höer, Ariane, Offermann, Stefan, Buschauer, Armin and Schunack, Walter (1992) Histamine increases Ca^2+ in dibutyryl cyclic AMP-differentiated HL-60 cells via H_1-receptors and is an incomplete secretagogue. Mol. Pharmacol. 42, pp. 227-234.

Hirschfeld, Jürgen, Buschauer, Armin, Elz, Sigurd, Schunack, Walter, Ruat, Martial, Traiffort, Elisabeth and Schwartz, Jean-Charles (1992) Iodoaminopotentidine and related compounds: a new class of ligands with high affinity and selectivity for the histamine H_2-receptor. Journal of Medicinal Chemistry 35, pp. 2231-2238. Fulltext not available.

Sellier, Christian, Elz, Sigurd, Buschauer, Armin and Schunack, Walter (1992) The effect of lipophilic substituents on the H_2-histaminergic activity of some close analogues of impromidine. Arch. Pharm. (Weinheim) 325, pp. 471-476. Fulltext not available.

Sellier, Christian, Elz, Sigurd, Buschauer, Armin and Schunack, Walter (1992) Zur Synthese von (Z)- und (E)-3-(1H-imidazol-4-yl)-2-propenamin und einigen 3-(1H-Imidazol-4-yl)propanaminen. Liebigs Ann. Chem. 1992, pp. 317-322. Fulltext not available.

1988

Elz, Sigurd, Kimmel, Ursula, Buschauer, Armin and Schunack, Walter (1988) Halogenderivate von N-[3-(Imidazol-4-yl)propyl]-N'-(2-phenylthioalkyl)guanidinen. Sci. Pharm. 56, pp. 229-234. Fulltext not available.

Elz, Sigurd and Schunack, Walter (1988) Impromidin-analoge Guanidine: Synthese und Wirkung am Histamin-H2-Rezeptor. 29. Mitteilung: Histamin-Analoga. Arzneimittel-Forschung 38 (3), pp. 327-332. Fulltext not available.

Elz, Sigurd and Schunack, W. (1988) [H2-antagonistic activity of the impromidine analog, cyanoguanidine. 37. H2 antihistaminics]. Arzneimittelforschung 38 (1), pp. 7-10. Fulltext not available.

1987

Elz, Sigurd and Schunack, Walter (1987) Darstellung und H2-agonistische Aktivität alkylsubstituierter 3-(Imidazol-4-yl)propylguanidine. Archiv der Pharmazie 320 (2), pp. 182-185. Fulltext not available.

1986

Buschauer, Armin, Schickaneder, Helmut, Elz, Sigurd, Schunack, Walter, Szelenyi, Istvan, Baumann, Gert and Ahrens, K.-H. (1986) Guanidinderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthal­tende Arzneimittel. Patentanmeldung P 35 12 084.3 (2.4.1985), Offenlegungsschrift DE 35 12 084 A. Fulltext not available.

1985

Schunack, Walter, Buschauer, Armin, Büyüktimkim, Servet, Dziuron, Peter, Elz, Sigurd, Gerhardt, Günter, Lebenstedt, Ernst, Lennartz, Hans-Gerd, Schwarz, Siegfried, Spitzhoff, Margrit and Steffens, Robert (1985) 2. Histamine agonists - chemistry and structure-activity relationships. In: Dahlbom, R. and Nilsson, J. L. G., (eds.) VIIIth International Symposium on Medicinal Chemistry. Swedish Pharmaceutical Press, Stockholm, pp. 169-182. Fulltext not available.

Buschauer, Armin, Schickaneder, Helmut, Schunack, Walter, Elz, Sigurd, Szelenyi, Istvan, Baumann, Gert and Ahrens, K.-H. (1985) Imidazolylalkylguanidine, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel. Patentanmeldung 85 114 205.9 (12.11.1985), Eur. Pat. Appl. EP 0 199 845 (5.11.1986). Fulltext not available.

1984

Büyüktimkin, Servet, Elz, Sigurd, Dräger, Martin and Schunack, Walter (1984) Chinazolinone, 1. Mitt. Darstellung, Kristallstruktur und Wirkung von 2-Methyl-3(4-oxo-3-phenyl-thiazolidin-2-ylidenamino)-4-(3H)-chinazolin on. Archiv der Pharmazie 317 (9), pp. 797-802. Fulltext not available.

1983

Elz, Sigurd, Buschauer, Armin, Dräger, M. and Schunack, Walter (1983) Darstellung, Eigenschaften und Kristallstruktur der N-[2-(4,5,6,7-Tetrahydro-2-benzimidazolyl)ethyl]phthalamidsäure. Z. Naturforsch. 38b, pp. 1203-1207. Fulltext not available.

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