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Bibliography of the Universität Regensburg
- University of Regensburg (99)
- Chemistry and Pharmacy (99)
- Institute of Pharmacy (99)
- Pharmaceutical/Medicinal Chemistry I (Prof. Elz) (99)
- Institute of Pharmacy (99)
- Chemistry and Pharmacy (99)
Number of items at this level: 99.
2023
Hoffelner, Beate Sandra, Andreev, Stanislav 
, Plank, Nicole and Koch, Pierre
(2023)
Photocaging of Pyridinylimidazole-Based Covalent JNK3 Inhibitors Affords Spatiotemporal Control of the Binding Affinity in Live Cells.
Pharmaceuticals 16 (2), p. 264.
2022
Bresinsky, Merlin, Strasser, Jessica M., Hubmann, Alexander, Vallaster, Bernadette, McCue, William M., Fuller, Jessica, Singh, Gurpreet, Nelson, Kathryn M., Cuellar, Matthew E., Finzel, Barry C., Ashe, Karen H., Walters, Michael A. and Pockes, Steffen
(2022)
Characterization of caspase‐2 inhibitors based on specific sites of caspase‐2‐mediated proteolysis.
Archiv der Pharmazie 355 (9), p. 2200095.
Pilsl, Bernadette
(2022)
Neue Indolderivate als FLT3-Inhibitoren und chimäre FLT3- und HDAC-Inhibitoren: Synthese und biologische Testung.
PhD, Universität Regensburg.
2021
Pockes, Steffen and Tropmann, Katharina
(2021)
Histamine H2 receptor radioligands: triumphs and challenges.
Future Medicinal Chemistry 13 (12), pp. 1073-1081.
Rosier, Niklas, Grätz, Lukas, Schihada, Hannes, Möller, Jan, Işbilir, Ali, Humphrys, Laura J., Nagl, Martin, Seibel, Ulla, Lohse, Martin J. and Pockes, Steffen
(2021)
A Versatile Sub-Nanomolar Fluorescent Ligand Enables NanoBRET Binding Studies and Single-Molecule Microscopy at the Histamine H3 Receptor.
Journal of Medicinal Chemistry 64 (15), pp. 11695-11708.
Fulltext not available.
(2021)
A Versatile Sub-Nanomolar Fluorescent Ligand Enables NanoBRET Binding Studies and Single-Molecule Microscopy at the Histamine H3 Receptor.
Journal of Medicinal Chemistry 64 (15), pp. 11695-11708.
Fulltext not available.
Tropmann, Katharina, Bresinsky, Merlin, Forster, Lisa, Mönnich, Denise, Buschauer, Armin , Wittmann, Hans-Joachim, Hübner, Harald, Gmeiner, Peter, Pockes, Steffen and Strasser, Andrea
(2021)
Abolishing Dopamine D2long/D3 Receptor Affinity of Subtype-Selective Carbamoylguanidine-Type Histamine H2 Receptor Agonists.
Journal of Medicinal Chemistry 64 (12), pp. 8684-8709.
Fulltext not available.
, Wittmann, Hans-Joachim, Hübner, Harald, Gmeiner, Peter, Pockes, Steffen and Strasser, Andrea
(2021)
Abolishing Dopamine D2long/D3 Receptor Affinity of Subtype-Selective Carbamoylguanidine-Type Histamine H2 Receptor Agonists.
Journal of Medicinal Chemistry 64 (12), pp. 8684-8709.
Fulltext not available.
Gergs, Ulrich, Büxel, Maren L., Bresinsky, Merlin, Kirchhefer, Uwe, Fehse, Charlotte, Höring, Carina, Hofmann, Britt, Marušáková, Margaréta, Čináková, Aneta, Schwarz, Rebecca, Pockes, Steffen and Neumann, Joachim
(2021)
Cardiac Effects of Novel Histamine H2 Receptor Agonists.
Journal of Pharmacology and Experimental Therapeutics 379 (3), pp. 223-234.
Fulltext not available.
and Neumann, Joachim
(2021)
Cardiac Effects of Novel Histamine H2 Receptor Agonists.
Journal of Pharmacology and Experimental Therapeutics 379 (3), pp. 223-234.
Fulltext not available.
Biselli, Sabrina, Bresinsky, Merlin, Tropmann, Katharina , Forster, Lisa, Honisch, Claudia, Buschauer, Armin , Bernhardt, Günther and Pockes, Steffen
(2021)
Pharmacological characterization of a new series of carbamoylguanidines reveals potent agonism at the H2R and D3R.
European Journal of Medicinal Chemistry 214, p. 113190.
Fulltext not available.
, Forster, Lisa, Honisch, Claudia, Buschauer, Armin , Bernhardt, Günther and Pockes, Steffen
(2021)
Pharmacological characterization of a new series of carbamoylguanidines reveals potent agonism at the H2R and D3R.
European Journal of Medicinal Chemistry 214, p. 113190.
Fulltext not available.
Szczepańska, Katarzyna, Pockes, Steffen , Podlewska, Sabina, Höring, Carina , Mika, Kamil, Latacz, Gniewomir, Bednarski, Marek, Siwek, Agata, Karcz, Tadeusz, Nagl, Martin, Bresinsky, Merlin, Mönnich, Denise, Seibel, Ulla, Kuder, Kamil J., Kotańska, Magdalena, Stark, Holger, Elz, Sigurd and Kieć-Kononowicz, Katarzyna
(2021)
Structural modifications in the distal, regulatory region of histamine H3 receptor antagonists leading to the identification of a potent anti-obesity agent.
European Journal of Medicinal Chemistry 213, p. 113041.
Fulltext not available.
, Podlewska, Sabina, Höring, Carina , Mika, Kamil, Latacz, Gniewomir, Bednarski, Marek, Siwek, Agata, Karcz, Tadeusz, Nagl, Martin, Bresinsky, Merlin, Mönnich, Denise, Seibel, Ulla, Kuder, Kamil J., Kotańska, Magdalena, Stark, Holger, Elz, Sigurd and Kieć-Kononowicz, Katarzyna
(2021)
Structural modifications in the distal, regulatory region of histamine H3 receptor antagonists leading to the identification of a potent anti-obesity agent.
European Journal of Medicinal Chemistry 213, p. 113041.
Fulltext not available.
2020
Höring, Carina , Seibel, Ulla , Tropmann, Katharina, Grätz, Lukas , Mönnich, Denise , Pitzl, Sebastian, Bernhardt, Günther , Pockes, Steffen and Strasser, Andrea
(2020)
A Dynamic, Split-Luciferase-Based Mini-G Protein Sensor to Functionally Characterize Ligands at All Four Histamine Receptor Subtypes.
International Journal of Molecular Sciences 21 (22), p. 8440.
Naporra, Franziska Gertraud
(2020)
Synthese und pharmakologische Charakterisierung neuer trizyklischer Liganden am Histamin-H1/H4-Rezeptor.
PhD, Universität Regensburg.
Grätz, Lukas, Tropmann, Katharina, Bresinsky, Merlin, Müller, Christoph, Bernhardt, Günther and Pockes, Steffen
(2020)
NanoBRET binding assay for histamine H2 receptor ligands using live recombinant HEK293T cells.
Scientific Reports 10, p. 13288.
Forster, Lisa , Grätz, Lukas, Mönnich, Denise, Bernhardt, Günther and Pockes, Steffen
(2020)
A Split Luciferase Complementation Assay for the Quantification of β-Arrestin2 Recruitment to Dopamine D2-Like Receptors.
International Journal of Molecular Sciences 21 (17), p. 6103.
Sellmer, Andreas, Pilsl, Bernadette, Beyer, Mandy, Pongratz, Herwig, Wirth, Lukas, Elz, Sigurd, Dove, Stefan, Henninger, Sven Julian, Spiekermann, Karsten, Polzer, Harald, Klaeger, Susan, Kuster, Bernhard, Böhmer, Frank D., Fiebig, Heinz-Herbert, Krämer, Oliver H. and Mahboobi, Siavosh
(2020)
A series of novel aryl-methanone derivatives as inhibitors of FMS-like tyrosine kinase 3 (FLT3) in FLT3-ITD-positive acute myeloid leukemia.
European Journal of Medicinal Chemistry 193, p. 112232.
Fulltext not available.
Schihada, Hannes , Ma, Xiaoyuan, Zabel, Ulrike, Vischer, Henry F., Schulte, Gunnar , Leurs, Rob, Pockes, Steffen and Lohse, Martin J.
(2020)
Development of a Conformational Histamine H3 Receptor Biosensor for the Synchronous Screening of Agonists and Inverse Agonists.
ACS Sensors 5 (6), pp. 1734-1742.
Fulltext not available.
, Ma, Xiaoyuan, Zabel, Ulrike, Vischer, Henry F., Schulte, Gunnar , Leurs, Rob, Pockes, Steffen and Lohse, Martin J.
(2020)
Development of a Conformational Histamine H3 Receptor Biosensor for the Synchronous Screening of Agonists and Inverse Agonists.
ACS Sensors 5 (6), pp. 1734-1742.
Fulltext not available.
Tropmann, Katharina, Höring, Carina , Plank, Nicole and Pockes, Steffen
(2020)
Discovery of a G Protein-Biased Radioligand for the Histamine H2 Receptor with Reversible Binding Properties.
Journal of Medicinal Chemistry 63 (21), pp. 13090-13102.
Fulltext not available.
, Plank, Nicole and Pockes, Steffen
(2020)
Discovery of a G Protein-Biased Radioligand for the Histamine H2 Receptor with Reversible Binding Properties.
Journal of Medicinal Chemistry 63 (21), pp. 13090-13102.
Fulltext not available.
2019
Grünstein, Elisabeth
(2019)
Selektive HDAC6-Inhibitoren: Synthese und biologische Testung.
PhD, Universität Regensburg.
Pockes, Steffen, Wifling, David , Buschauer, Armin and Elz, Sigurd
(2019)
Structure‐Activity Relationship of Hetarylpropylguanidines Aiming at the Development of Selective Histamine Receptor Ligands †.
ChemistryOpen 8 (3), pp. 285-297.
Rustler, Karin , Pockes, Steffen and König, Burkhard
(2019)
Light-Switchable Antagonists for the Histamine H1 Receptor at the Isolated Guinea Pig Ileum.
ChemMedChem 14 (6), pp. 636-644.
Fulltext not available.
, Pockes, Steffen and König, Burkhard
(2019)
Light-Switchable Antagonists for the Histamine H1 Receptor at the Isolated Guinea Pig Ileum.
ChemMedChem 14 (6), pp. 636-644.
Fulltext not available.
Wiegrebe, Wolfgang
(2019)
Adam and Eve's Origin According to Islam: A Response to Daud Abdul-Fattah Batchelor.
Theology and Science 17 (4), pp. 455-468.
Fulltext not available.
Rustler, Karin , Pockes, Steffen and König, Burkhard
(2019)
Cover Feature: Light‐Switchable Antagonists for the Histamine H 1 Receptor at the Isolated Guinea Pig Ileum (ChemMedChem 6/2019).
ChemMedChem 14 (6), p. 614.
Fulltext not available.
, Pockes, Steffen and König, Burkhard
(2019)
Cover Feature: Light‐Switchable Antagonists for the Histamine H 1 Receptor at the Isolated Guinea Pig Ileum (ChemMedChem 6/2019).
ChemMedChem 14 (6), p. 614.
Fulltext not available.
Grünstein, Elisabeth, Sellmer, Andreas and Mahboobi, Siavosh
(2019)
Enantioselective synthesis and biological investigation of tetrahydro‐β‐carboline‐based HDAC6 inhibitors with improved solubility.
Archiv der Pharmazie 352 (6), p. 1900026.
Fulltext not available.
Beyer, M., Romanski, A., Mustafa, Al-Hassan M. and Sellmer, Andreas
(2019)
HDAC3 is essential for Human Leukemic Cell Growth and the Expression of β-catenin, MYC, and WT1.
Cancers 11, p. 1436.
Soliman, Beatrice, Wang, Ning, Zagotto, Giuseppe and Pockes, Steffen
(2019)
Synthesis and biological evaluation of heteroalicyclic cyanoguanidines at histamine receptors.
Archiv der Pharmazie 352 (9), p. 1900107.
Fulltext not available.
(2019)
Synthesis and biological evaluation of heteroalicyclic cyanoguanidines at histamine receptors.
Archiv der Pharmazie 352 (9), p. 1900107.
Fulltext not available.
2018
Pockes, Steffen , Wifling, David , Keller, Max, Buschauer, Armin and Elz, Sigurd
(2018)
Highly Potent, Stable, and Selective Dimeric Hetarylpropylguanidine-Type Histamine H2 Receptor Agonists.
ACS Omega 2018 (3), pp. 2865-2882.
Pockes, Steffen
(2018)
Synthese und pharmakologische Charakterisierung von Heteroarylpropylguanidin-Derivaten an Histamin-Rezeptorsubtypen: Struktur-Wirkungsbeziehungen mono- und bivalenter Liganden.
PhD, Universität Regensburg.
Leonhardt, Michel, Sellmer, Andreas , Krämer, Oliver H., Dove, Stefan, Elz, Sigurd, Kraus, Birgit, Beyer, Mandy and Mahboobi, Siavosh
(2018)
Design and biological evaluation of tetrahydro-β-carboline derivatives as highly potent histone deacetylase 6 (HDAC6) inhibitors.
European Journal of Medicinal Chemistry 152, pp. 329-357.
Fulltext not available.
, Krämer, Oliver H., Dove, Stefan, Elz, Sigurd, Kraus, Birgit, Beyer, Mandy and Mahboobi, Siavosh
(2018)
Design and biological evaluation of tetrahydro-β-carboline derivatives as highly potent histone deacetylase 6 (HDAC6) inhibitors.
European Journal of Medicinal Chemistry 152, pp. 329-357.
Fulltext not available.
Ridinger, Johannes, Koeneke, Emily, Kolbinger, Fiona R., Koerholz, Katharina, Mahboobi, Siavosh, Hellweg, Lars, Gunkel, Nikolas, Miller, Aubry K., Peterziel, Heike, Schmezer, Peter, Hamacher-Brady, Anne , Witt, Olaf and Oehme, Ina
(2018)
Dual role of HDAC10 in lysosomal exocytosis and DNA repair promotes neuroblastoma chemoresistance.
Scientific Reports 8 (1).
Fulltext not available.
, Witt, Olaf and Oehme, Ina
(2018)
Dual role of HDAC10 in lysosomal exocytosis and DNA repair promotes neuroblastoma chemoresistance.
Scientific Reports 8 (1).
Fulltext not available.
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(2018)
Human platelet lysate as validated replacement for animal serum to assess chemosensitivity.
ALTEX.
Fulltext not available.
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(2018)
Human platelet lysate as validated replacement for animal serum to assess chemosensitivity.
ALTEX.
Fulltext not available.
2017
Stojanovic, N., Hassan, Z., Wirth, M., Wenzel, P., Beyer, M., Schäfer, C., Brand, P., Kroemer, A., Stauber, R. H., Schmid, R. M., Arlt, A., Sellmer, A., Mahboobi, S., Rad, R., Reichert, M., Saur, D., Krämer, O. H. and Schneider, G.
(2017)
HDAC1 and HDAC2 integrate the expression of p53 mutants in pancreatic cancer.
Oncogene 36 (13), pp. 1804-1815.
Fulltext not available.
Tsitsipatis, Dimitrios, Jayavelu, Ashok Kumar, Müller, Jörg P., Bauer, Reinhard, Schmidt-Arras, Dirk, Mahboobi, Siavosh, Schnöder, Tina M., Heidel, Florian and Böhmer, Frank D.
(2017)
Synergistic killing of FLT3ITD-positive AML cells by combined inhibition of tyrosine-kinase activity and N-glycosylation.
Oncotarget 8 (16).
Fulltext not available.
2016
Sadek, Bassem, Khan, Nadia, Darras, Fouad H., Pockes, Steffen and Decker, Michael
(2016)
The dual-acting AChE inhibitor and H3 receptor antagonist UW-MD-72 reverses amnesia induced by scopolamine or dizocilpine in passive avoidance paradigm in rats.
Physiology & Behavior 165, pp. 383-391.
Fulltext not available.
and Decker, Michael
(2016)
The dual-acting AChE inhibitor and H3 receptor antagonist UW-MD-72 reverses amnesia induced by scopolamine or dizocilpine in passive avoidance paradigm in rats.
Physiology & Behavior 165, pp. 383-391.
Fulltext not available.
Naporra, Franziska, Gobleder, Susanne, Wittmann, Hans-Joachim, Spindler, Julia, Bodensteiner, Michael, Bernhardt, Günther, Hübner, Harald, Gmeiner, Peter, Elz, Sigurd and Strasser, Andrea
(2016)
Dibenzo[b,f][1,4]oxazepines and dibenzo[b,e]oxepines: Influence of the chlorine substitution pattern on the pharmacology at the H1R, H4R, 5-HT2AR and other selected GPCRs.
Pharmacological Research 113, pp. 610-625.
(In Press)
Fulltext not available.
Gobleder, Susanne
(2016)
Synthesis and pharmacological characterization of new histamine H1-/H4-receptor ligands derived from the atypical antipsychotic drug Clozapine.
PhD, Universität Regensburg.
Hammer, Sebastian, Gobleder, Susanne, Naporra, Franziska, Wittmann, Hans-Joachim, Elz, Sigurd, Heinrich, Markus and Strasser, Andrea
(2016)
2,4-Diaminopyrimidines as dual ligands at the histamine H1 and H4 receptor - H1/H4-receptor selectivity.
Bioorganic & Medicinal Chemistry Letters 26, pp. 292-300.
Fulltext not available.
and Strasser, Andrea
(2016)
2,4-Diaminopyrimidines as dual ligands at the histamine H1 and H4 receptor - H1/H4-receptor selectivity.
Bioorganic & Medicinal Chemistry Letters 26, pp. 292-300.
Fulltext not available.
Naporra, Franziska, Gobleder, Susanne, Wittmann, Hans-Joachim, Spindler, Julia, Bodensteiner, Michael, Bernhardt, Günther, Hübner, Harald, Gmeiner, Peter , Elz, Sigurd and Strasser, Andrea
(2016)
Dibenzo[ b , f ][1,4]oxazepines and dibenzo[ b , e ]oxepines: Influence of the chlorine substitution pattern on the pharmacology at the H 1 R, H 4 R, 5-HT 2A R and other selected GPCRs.
Pharmacological Research 113, pp. 610-625.
Fulltext not available.
, Elz, Sigurd and Strasser, Andrea
(2016)
Dibenzo[ b , f ][1,4]oxazepines and dibenzo[ b , e ]oxepines: Influence of the chlorine substitution pattern on the pharmacology at the H 1 R, H 4 R, 5-HT 2A R and other selected GPCRs.
Pharmacological Research 113, pp. 610-625.
Fulltext not available.
2015
Helm, Klaus
(2015)
Synthese und funktionelle In-vitro-Pharmakologie neuer Liganden des 5-HT2A-Rezeptors aus der Klasse der Tryptamine.
PhD, Universität Regensburg.
Baumeister, Paul, Erdmann, Daniela, Biselli, Sabrina, Kagermeier, Nicole, Elz, Sigurd, Bernhardt, Günther and Buschauer, Armin
(2015)
3HUR-DE257: Development of a tritium-labeled squaramide-type selective histamine H2 receptor antagonist.
ChemMedChem 10 (1), pp. 83-93.
Fulltext not available.
Wiesneth, Stefan, Petereit, Frank and Jürgenliemk, Guido
(2015)
Salix daphnoides: A Screening for Oligomeric and Polymeric Proanthocyanidins.
Molecules 20 (8), pp. 13764-13779.
2014
Darras, Fouad, Pockes, Steffen , Huang, Guozheng, Wehle, Sarah, Strasser, Andrea, Wittmann, Hans-Joachim, Nimczick, Martin, Sotriffer, Christoph and Decker, Michael
(2014)
Synthesis, biological evaluation, and computational studies of tri- and tetracyclic nitrogen-bridgehead compounds as potent dual-acting AChE inhibitors and hH3 receptor antagonists.
ACS Chemical Neuroscience 5 (3), pp. 225-242.
Fulltext not available.
, Huang, Guozheng, Wehle, Sarah, Strasser, Andrea, Wittmann, Hans-Joachim, Nimczick, Martin, Sotriffer, Christoph and Decker, Michael
(2014)
Synthesis, biological evaluation, and computational studies of tri- and tetracyclic nitrogen-bridgehead compounds as potent dual-acting AChE inhibitors and hH3 receptor antagonists.
ACS Chemical Neuroscience 5 (3), pp. 225-242.
Fulltext not available.
Geyer, Roland, Igel, Patrick, Kaske, Melanie, Elz, Sigurd and Buschauer, Armin
(2014)
Synthesis, SAR and selectivity of 2-acyl- and 2-cyano-1-hetarylalkyl-guanidines at the four histamine receptor subtypes: a bioisosteric approach.
MedChemComm 5 (1), pp. 72-81.
Fulltext not available.
2013
Sadek, Bassem, Alisch, Rudi, Buschauer, Armin and Elz, Sigurd
(2013)
Synthesis and dual histamine H1 and H2 receptor antagonist activity of cyanoguanidine derivatives.
Molecules 18 (11), pp. 14186-14202.
2012
Eswayah, Asma Mohamed
(2012)
Neue Imidazol- und Indolderivate - Synthese und biologische in-vitro-Prüfungen.
PhD, Universität Regensburg.
Birnkammer, Tobias, Spickenreither, Anja, Brunskole, Irena, Lopuch, Miroslaw, Kagermeier, Nicole, Bernhardt, Günther, Dove, Stefan, Seifert, Roland, Elz, Sigurd and Buschauer, Armin
(2012)
The bivalent ligand approach leads to highly potent and selective acylguanidine-type histamine H2 receptor agonists.
Journal of Medicinal Chemistry 55 (3), pp. 1147-1160.
Fulltext not available.
Strasser, Andrea and Wittmann, Hans-Joachim
(2012)
Binding of Ligands to GPCRs – How Valid is a ThermodynamicDiscrimination of Antagonists and Agonists? Journal of Physical Chemistry & Biophysics 2012.
2011
Silva, Maria Elena, Heim, Ralf, Strasser, Andrea, Elz, Sigurd and Dove, Stefan
(2011)
Theoretical studies on the interaction of partial agonists with the 5-HT(2A) receptor.
Journal of computer-aided molecular design 25 (1), pp. 51-66.
Fulltext not available.
Wittmann, Hans-Joachim, Elz, Sigurd, Seifert, Roland and Strasser, Andrea
(2011)
Na-methylated phenylhistamines exhibit affinity to the hH4R - a pharmacological and molecular modelling study.
Naunyn Schmiedeberg's Arch Pharmacol 384, pp. 287-299.
Fulltext not available.
2010
Ghorai, Prasanta, Kraus, Anja, Birnkammer, Tobias, Geyer, Roland, Bernhardt, Günther, Dove, Stefan, Seifert, Roland, Elz, Sigurd and Buschauer, Armin
(2010)
Chiral N(G)-acylated hetarylpropylguanidine-type histamine H2 receptor agonists do not show significant stereoselectivity.
Bioorganic & Medicinal Chemistry Letters 20 (10), pp. 3173-3176.
Fulltext not available.
Matzdorf, Thorsten
(2010)
5-Carboxamidotryptamin-Derivate als Liganden für 5-HT7- und 5-HT2A-Rezeptoren: Synthese und In-vitro-Pharmakologie.
PhD, Universität Regensburg.
Schneider, Erich H., Schnell, David, Strasser, Andrea, Dove, Stefan and Seifert, Roland
(2010)
Impact of the DRY Motif and the Missing "Ionic Lock" on Constitutive Activity and G-Protein Coupling of the Human Histamine H-4 Receptor.
Journal of Pharmacology and Experimental Therapeutics 333 (2), pp. 382-392.
Fulltext not available.
2009
Prainer, Bianca-Cristine
(2009)
Tryptamin-Derivate als 5-HT4-Rezeptorliganden: Synthese und in-vitro-Pharmakologie.
PhD, Universität Regensburg.
Jenning, Stefan
(2009)
Ondansetron-analoge 5-HT3-Rezeptorliganden: Synthese, Stereochemie und in-vitro-Pharmakologie.
PhD, Universität Regensburg.
Igel, Patrick, Schneider, Erich, Schnell, David, Elz, Sigurd, Seifert, Roland and Buschauer, Armin
(2009)
N(G)-Acylated imidazolylpropylguanidines as potent histamine H4 receptor agonists: selectivity by variation of the N(G)-substituent.
Journal of Medicinal Chemistry 52 (8), pp. 2623-2627.
Fulltext not available.
Kraus, Anja, Ghorai, Prasanta, Birnkammer, Tobias, Schnell, David, Elz, Sigurd, Seifert, Roland, Dove, Stefan, Bernhardt, Günther and Buschauer, Armin
(2009)
N(G)-Acylated aminothiazolylpropylguanidines as potent and selective histamine H2 receptor agonists.
ChemMedChem 4 (2), pp. 232-240.
Fulltext not available.
Mahboobi, Siavosh, Dove, Stefan, Sellmer, Andreas, Winkler, Matthias, Eichhorn, Emerich, Pongratz, Herwig, Ciossek, Thomas, Baer, Thomas, Maier, Thomas and Beckers, Thomas
(2009)
Design of chimeric histone deacetylase- and tyrosine kinase-inhibitors: a series of imatinib hybrides as potent inhibitors of wild-type and mutant BCR-ABL, PDGF-Rbeta, and histone deacetylases.
Journal of medicinal chemistry 52 (8), pp. 2265-79.
Fulltext not available.
Strasser, Andrea, Wittmann, Hans-Joachim, Kunze, Marc, Elz, Sigurd and Seifert, Roland
(2009)
Molecular basis for the selective interaction of synthetic agonists with the human histamine H1-receptor compared with the guinea-pig H1-receptor.
Mol Pharmacol : Molecular pharmacology 75, pp. 454-465.
Fulltext not available.
2008
Ghorai, Prasanta, Kraus, Anja, Keller, Max, Götte, Carsten, Igel, Patrick, Schneider, Erich, Schnell, David, Bernhardt, Günther, Dove, Stefan, Zabel, Manfred, Elz, Sigurd, Seifert, Roland and Buschauer, Armin
(2008)
Acylguanidines as bioisosteres of guanidines: N(G)-acylated imidazolylpropylguanidines, a new class of histamine H2 receptor agonists.
Journal of Medicinal Chemistry 51 (22), pp. 7193-7204.
Fulltext not available.
Schumacher, Matthias
(2008)
Chirale Arylmethoxytryptamine als 5-HT2B-Rezeptoragonisten: Synthese, Analytik und in-vitro-Pharmakologie.
PhD, Universität Regensburg.
Strasser, Andrea, Striegl, Birgit, Wittmann, Hans-Joachim and Seifert, Roland
(2008)
Pharmacological Profile of Histaprodifens at Four Recombinant Histamine H1 Receptor Species Isoforms.
Journal of Pharmacology and Experimental Therapeutics 324, pp. 60-71.
Fulltext not available.
Dove, Stefan, Seifert, Roland, Elz, Sigurd and Buschauer, Armin
(2008)
Frontiers in medicinal chemistry in Regensburg.
ChemMedChem 3 (8), pp. 1181-1184.
Fulltext not available.
Mahboobi, Siavosh, Sellmer, Andreas, Eswayah, Asma, Elz, Sigurd, Uecker, Andrea and Böhmer, Frank-D.
(2008)
Inhibition of PDGFR tyrosine kinase activity by a series of novel N-(3-(4-(pyridin-3-yl)-1H-imidazol-2-ylamino)phenyl)amides: a SAR study on the bioisosterism of pyrimidine and imidazole.
European journal of medicinal chemistry 43 (7), pp. 1444-1453.
Fulltext not available.
2007
Kunze, Marc
(2007)
Histamin-H1-Rezeptoragonisten vom Suprahistaprodifen- und 2-Phenylhistamin-Typ und 2-substituierte Imidazolylpropan-Derivate als Liganden für H1/H2/H3/H4-Rezeptoren. Neue Synthesestrategien und pharmakologische Testung.
PhD, Universität Regensburg.
Walbrun, Peter
(2007)
Repopulation genetisch veränderter Kupffer-Zellen und Evaluation deren Effekte in einem akuten hepatischen Schädigungsmodell.
PhD, Universität Regensburg.
Striegl, Birgit
(2007)
Synthese und funktionelle in-vitro-Pharmakologie neuer Histamin-H1-Rezeptoragonisten aus der Suprahistaprodifen-Reihe.
PhD, Universität Regensburg.
Mahboobi, Siavosh, Uecker, A., Cénac, C., Sellmer, A., Eichhorn, E., Elz, Sigurd, Böhmer, F.-D. and Dove, Stefan
(2007)
Inhibition of FLT3 and PDGFR tyrosine kinase activity by bis(benzo[b]furan-2-yl)methanones.
Bioorganic & medicinal chemistry 15 (5), pp. 2187-2197.
Fulltext not available.
2006
Bäumel, Monika
(2006)
Funktionelle Charakterisierung von p75TNF-Rezeptor-Isoformen.
PhD, Universität Regensburg.
Xie, Sheng-Xue, Kraus, Anja, Ghorai, Prasanta, Ye, Qi-Zhuang, Elz, Sigurd, Buschauer, Armin and Seifert, Roland
(2006)
N1-(3-Cyclohexylbutanoyl)-N2-[3-(1H-imidazol-4-
yl)propyl]guanidine (UR-AK57), a Potent Partial Agonist for the Human Histamine H1- and H2- Receptors. Journal of Pharmacology and Experimental Therapeutics 317 (3), pp. 1262-1268. Fulltext restricted.
yl)propyl]guanidine (UR-AK57), a Potent Partial Agonist for the Human Histamine H1- and H2- Receptors. Journal of Pharmacology and Experimental Therapeutics 317 (3), pp. 1262-1268. Fulltext restricted.
Mahboobi, Siavosh, Uecker, A., Sellmer, A., Cénac, C., Höcher, H., Pongratz, H., Hufsky, H., Trümpler, A., Sicker, M., Heidel, F., Fischer, T., Stocking, C., Elz, Sigurd, Böhmer, F.-D. and Dove, Stefan
(2006)
Novel bis-(1H-indol-2-yl)-methanones as potent inhibitors of FLT3 and platelet-derived growth factor receptor tyrosine kinase.
Journal of Medicinal Chemistry 49 (11), pp. 3101-3115.
Fulltext not available.
2005
Sterns, Theobald
(2005)
Serum-Zytokinspiegel und Empfindlichkeit für Super-Infektionen im Maus-Sepsismodell.
PhD, Universität Regensburg.
Scherübl, Christoph
(2005)
Charakterisierung einer neuen Isoform des humanen p75TNF-Rezeptors.
PhD, Universität Regensburg.
2004
Dove, Stefan, Elz, Sigurd, Seifert, Roland and Buschauer, Armin
(2004)
Structure-Activity Relationships of Histamine H_2 Receptor Ligands,.
Mini-Rev. Med. Chem. 4 (9), pp. 941-954.
Fulltext not available.
2003
Li, Liantao, Kracht, Julia, Peng, Shiqi, Bernhardt, Günther, Elz, Sigurd and Buschauer, Armin
(2003)
Synthesis and pharmacological activity of fluorescent histamine H2 receptor antagonists related to potentidine,.
Bioorganic & Medicinal Chemistry Letters 13 (10), 0960-894.
Fulltext not available.
Böhmer, F. D., Karagyozov, L., Uecker, A., Serve, H., Botzki, A., Mahboobi, Siavosh and Dove, Stefan
(2003)
A single amino acid exchange inverts susceptibility of related receptor tyrosine kinases for the ATP-site inhibitor STI-571.
The Journal of Biological Chemistry 278 (7), pp. 5148-5155.
Fulltext not available.
Seifert, Roland, Wenzel-Seifert, Katharina, Bürckstümmer, Tilmann, Pertz, Heinz H., Schunack, Walter, Dove, Stefan, Buschauer, Armin and Elz, Sigurd
(2003)
Multiple differences in agonist and antagonist pharmacology between human and guinea pig histamine H1-receptor,.
Journal of Pharmacology and Experimental Therapeutics 305, pp. 1104-1115.
Fulltext not available.
2002
Mahboobi, Siavosh, Teller, S., Pongratz, H., Hufsky, H., Sellmer, A., Botzki, Alexander, Uecker, A., Beckers, T., Baasner, S., Schächtele, C., Überall, F., Kassack, M. U., Dove, Stefan and Böhmer, F.-D.
(2002)
Bis(1H-2-indolyl)methanones as a novel class of inhibitors of the platelet-derived growth factor receptor kinase.
Journal of Medicinal Chemistry 45 (5), pp. 1002-1018.
Fulltext not available.
1999
Mahboobi, Siavosh, Dove, Stefan, Kuhr, S. and Popp, A.
(1999)
Homo-arcyriaflavin: The synthesis of ring-expanded arcyriaflavin analogs.
The Journal of Organic Chemistry 64 (22), pp. 8130-8137.
Fulltext not available.
Mahboobi, Siavosh, Dove, Stefan, Kuhr, S. and Pongratz, Herwig
(1999)
Synthesis of arcyriarubine regioisomers by Pd(0)-catalysis or via lithiated indole derivatives - conformational analysis by semiempirical and X-ray methods.
Pharmazie 54 (11), pp. 820-827.
Fulltext not available.
1998
Mayer, Klaus K., Dove, Stefan, Pongratz, Herwig, Ertan, M. and Wiegrebe, Wolfgang
(1998)
Electron impact induced fragmentation of 4-aryl-4,6,7,8-tetrahydro-1H,3H-quinazolinone-2,5-diones.
Heterocycles 48 (6), pp. 1169-1183.
Fulltext not available.
1997
Mahboobi, Siavosh, Dove, Stefan, Bednarski, P. J., Kuhr, S., Burgemeister, Thomas and Schollmeyer, D.
(1997)
X-Ray Crystal Structure of Woodinine and Conformational Analysis by Means of Semiempirical and 1H-NMR Methods.
Journal of Natural Products-Copublished with the Am. Soc. of Pharmacognosy 60 (6), pp. 587-591.
Fulltext not available.
1994
Monti, J. M., Jantos, H., Leschke, C., Elz, Sigurd and Schunack, W.
(1994)
The selective histamine H1-receptor agonist 2-(3-trifluoromethylphenyl)histamine increases waking in the rat.
European neuropsychopharmacology 4 (4), pp. 459-462.
Fulltext not available.
Lowe, W., Elz, Sigurd, Reiser, H. and Schott, S.
(1994)
[7-fluoro-4-chromone-3-sulfur compounds].
Archiv der Pharmazie 327 (4), pp. 267-269.
Fulltext not available.
1993
Zingel, V., Elz, Sigurd and Schunack, W.
(1993)
Histamine analogues, XXXV: 2-substituted histamine derivatives containing classical moieties of H2-antagonists--a novel class of H1-agonists.
Archiv der Pharmazie 326 (3), pp. 143-151.
Fulltext not available.
Radwansky, A., Elz, Sigurd and Lehmann, J.
(1993)
Lactones, XXY: Synthesis and 5-HT2-receptor affinity of some fluorophenylated alpha-aminomethyllactones.
Archiv der Pharmazie 326 (4), pp. 243-244.
Fulltext not available.
Elz, Sigurd, Zimmermann, H. and Rehse, K.
(1993)
Selectivity of sterically fixed tryptamine and 5-methoxytryptamine derivatives for serotonin receptor subtypes, II: Structure-activity relationships and in vitro pharmacology of N-alkyl- and N,N-dialkyl-3- indolylbicyclo-[2.2.1]-heptane-2-amines.
Archiv der Pharmazie 326 (11), pp. 893-899.
Fulltext not available.
1992
Zingel, V., Elz, Sigurd and Schunack, W.
(1992)
Histamine analogues. 36th communication. Basically substituted histamine derivatives with H1-agonistic activity.
Pharmazie 47 (10), pp. 746-751.
Fulltext not available.
Sellier, Christian, Elz, Sigurd, Buschauer, Armin and Schunack, Walter
(1992)
Histamine analogues: imidazolylalkylguanidines, synthesis and in vitro pharmacology.
European Journal of Medicinal Chemistry 27, pp. 27-32.
Fulltext not available.
Seifert, Roland, Höer, Ariane, Offermann, Stefan, Buschauer, Armin and Schunack, Walter
(1992)
Histamine increases Ca^2+ in dibutyryl cyclic AMP-differentiated HL-60 cells via H_1-receptors and is an incomplete secretagogue.
Mol. Pharmacol. 42, pp. 227-234.
Hirschfeld, Jürgen, Buschauer, Armin, Elz, Sigurd, Schunack, Walter, Ruat, Martial, Traiffort, Elisabeth and Schwartz, Jean-Charles
(1992)
Iodoaminopotentidine and related compounds: a new class of ligands with high affinity and selectivity for the histamine H_2-receptor.
Journal of Medicinal Chemistry 35, pp. 2231-2238.
Fulltext not available.
Sellier, Christian, Elz, Sigurd, Buschauer, Armin and Schunack, Walter
(1992)
The effect of lipophilic substituents on the H_2-histaminergic activity of some close analogues of impromidine.
Arch. Pharm. (Weinheim) 325, pp. 471-476.
Fulltext not available.
Sellier, Christian, Elz, Sigurd, Buschauer, Armin and Schunack, Walter
(1992)
Zur Synthese von (Z)- und (E)-3-(1H-imidazol-4-yl)-2-propenamin und einigen 3-(1H-Imidazol-4-yl)propanaminen.
Liebigs Ann. Chem. 1992, pp. 317-322.
Fulltext not available.
1988
Elz, Sigurd, Kimmel, Ursula, Buschauer, Armin and Schunack, Walter
(1988)
Halogenderivate von N-[3-(Imidazol-4-yl)propyl]-N'-(2-phenylthioalkyl)guanidinen.
Sci. Pharm. 56, pp. 229-234.
Fulltext not available.
Elz, Sigurd and Schunack, Walter
(1988)
Impromidin-analoge Guanidine: Synthese und Wirkung am Histamin-H2-Rezeptor. 29. Mitteilung: Histamin-Analoga.
Arzneimittel-Forschung 38 (3), pp. 327-332.
Fulltext not available.
Elz, Sigurd and Schunack, W.
(1988)
[H2-antagonistic activity of the impromidine analog, cyanoguanidine. 37. H2 antihistaminics].
Arzneimittelforschung 38 (1), pp. 7-10.
Fulltext not available.
1987
Elz, Sigurd and Schunack, Walter
(1987)
Darstellung und H2-agonistische Aktivität alkylsubstituierter 3-(Imidazol-4-yl)propylguanidine.
Archiv der Pharmazie 320 (2), pp. 182-185.
Fulltext not available.
1986
Buschauer, Armin, Schickaneder, Helmut, Elz, Sigurd, Schunack, Walter, Szelenyi, Istvan, Baumann, Gert and Ahrens, K.-H.
(1986)
Guanidinderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel.
Patentanmeldung P 35 12 084.3 (2.4.1985), Offenlegungsschrift DE 35 12 084 A.
Fulltext not available.
1985
Schunack, Walter, Buschauer, Armin, Büyüktimkim, Servet, Dziuron, Peter, Elz, Sigurd, Gerhardt, Günter, Lebenstedt, Ernst, Lennartz, Hans-Gerd, Schwarz, Siegfried, Spitzhoff, Margrit and Steffens, Robert
(1985)
2. Histamine agonists - chemistry and structure-activity relationships.
In: Dahlbom, R. and Nilsson, J. L. G., (eds.)
VIIIth International Symposium on Medicinal Chemistry.
Swedish Pharmaceutical Press, Stockholm, pp. 169-182.
Fulltext not available.
Buschauer, Armin, Schickaneder, Helmut, Schunack, Walter, Elz, Sigurd, Szelenyi, Istvan, Baumann, Gert and Ahrens, K.-H.
(1985)
Imidazolylalkylguanidine, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel.
Patentanmeldung 85 114 205.9 (12.11.1985), Eur. Pat. Appl. EP 0 199 845 (5.11.1986).
Fulltext not available.
1984
Büyüktimkin, Servet, Elz, Sigurd, Dräger, Martin and Schunack, Walter
(1984)
Chinazolinone, 1. Mitt. Darstellung, Kristallstruktur und Wirkung von 2-Methyl-3(4-oxo-3-phenyl-thiazolidin-2-ylidenamino)-4-(3H)-chinazolin on.
Archiv der Pharmazie 317 (9), pp. 797-802.
Fulltext not available.
1983
Elz, Sigurd, Buschauer, Armin, Dräger, M. and Schunack, Walter
(1983)
Darstellung, Eigenschaften und Kristallstruktur der N-[2-(4,5,6,7-Tetrahydro-2-benzimidazolyl)ethyl]phthalamidsäure.
Z. Naturforsch. 38b, pp. 1203-1207.
Fulltext not available.
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