Number of items at this level: 78.
2020
2019
2018
Pockes, Steffen,
Wifling, David 
,
Keller, Max,
Buschauer, Armin 
and
Elz, Sigurd
(2018)
Highly Potent, Stable, and Selective Dimeric Hetarylpropylguanidine-Type Histamine H2 Receptor Agonists.
ACS Omega 2018 (3), pp. 2865-2882.
2017
Stojanovic, N.,
Hassan, Z.,
Wirth, M.,
Wenzel, P.,
Beyer, M.,
Schäfer, C.,
Brand, P.,
Kroemer, A.,
Stauber, R. H.,
Schmid, R. M.,
Arlt, A.,
Sellmer, A.,
Mahboobi, S.,
Rad, R.,
Reichert, M.,
Saur, D.,
Krämer, O. H. and
Schneider, G.
(2017)
HDAC1 and HDAC2 integrate the expression of p53 mutants in pancreatic cancer.
Oncogene 36 (13), pp. 1804-1815.
Fulltext not available.
Tsitsipatis, Dimitrios,
Jayavelu, Ashok Kumar,
Müller, Jörg P.,
Bauer, Reinhard,
Schmidt-Arras, Dirk,
Mahboobi, Siavosh,
Schnöder, Tina M.,
Heidel, Florian and
Böhmer, Frank D.
(2017)
Synergistic killing of FLT3ITD-positive AML cells by combined inhibition of tyrosine-kinase activity and N-glycosylation.
Oncotarget 8 (16).
Fulltext not available.
2016
Naporra, Franziska,
Gobleder, Susanne,
Wittmann, Hans-Joachim,
Spindler, Julia,
Bodensteiner, Michael,
Bernhardt, Günther,
Hübner, Harald,
Gmeiner, Peter,
Elz, Sigurd and
Strasser, Andrea
(2016)
Dibenzo[b,f][1,4]oxazepines and dibenzo[b,e]oxepines: Influence of the chlorine substitution pattern on the pharmacology at the H1R, H4R, 5-HT2AR and other selected GPCRs.
Pharmacological Research 113, pp. 610-625.
(In Press)
Fulltext not available.
Hammer, Sebastian,
Gobleder, Susanne,
Naporra, Franziska,
Wittmann, Hans-Joachim,
Elz, Sigurd,
Heinrich, Markus 
and
Strasser, Andrea
(2016)
2,4-Diaminopyrimidines as dual ligands at the histamine H1 and H4 receptor - H1/H4-receptor selectivity.
Bioorganic & Medicinal Chemistry Letters 26, pp. 292-300.
Fulltext not available.
Naporra, Franziska,
Gobleder, Susanne,
Wittmann, Hans-Joachim,
Spindler, Julia,
Bodensteiner, Michael,
Bernhardt, Günther,
Hübner, Harald,
Gmeiner, Peter 
,
Elz, Sigurd and
Strasser, Andrea
(2016)
Dibenzo[ b , f ][1,4]oxazepines and dibenzo[ b , e ]oxepines: Influence of the chlorine substitution pattern on the pharmacology at the H 1 R, H 4 R, 5-HT 2A R and other selected GPCRs.
Pharmacological Research 113, pp. 610-625.
Fulltext not available.
2015
Baumeister, Paul,
Erdmann, Daniela,
Biselli, Sabrina,
Kagermeier, Nicole,
Elz, Sigurd,
Bernhardt, Günther and
Buschauer, Armin
(2015)
3HUR-DE257: Development of a tritium-labeled squaramide-type selective histamine H2 receptor antagonist.
ChemMedChem 10 (1), pp. 83-93.
Fulltext not available.
2014
Geyer, Roland,
Igel, Patrick,
Kaske, Melanie,
Elz, Sigurd and
Buschauer, Armin
(2014)
Synthesis, SAR and selectivity of 2-acyl- and 2-cyano-1-hetarylalkyl-guanidines at the four histamine receptor subtypes: a bioisosteric approach.
MedChemComm 5 (1), pp. 72-81.
Fulltext not available.
Darras, Fouad,
Pockes, Steffen,
Huang, Guozheng,
Wehle, Sarah,
Strasser, Andrea,
Wittmann, Hans-Joachim,
Nimczick, Martin,
Sotriffer, Christoph and
Decker, Michael
(2014)
Synthesis, biological evaluation, and computational studies of tri- and tetracyclic nitrogen-bridgehead compounds as potent dual-acting AChE inhibitors and hH3 receptor antagonists.
ACS Chemical Neuroscience 5, pp. 225-242.
Fulltext not available.
2013
2012
Birnkammer, Tobias,
Spickenreither, Anja,
Brunskole, Irena,
Lopuch, Miroslaw,
Kagermeier, Nicole,
Bernhardt, Günther,
Dove, Stefan,
Seifert, Roland,
Elz, Sigurd and
Buschauer, Armin
(2012)
The bivalent ligand approach leads to highly potent and selective acylguanidine-type histamine H2 receptor agonists.
Journal of Medicinal Chemistry 55 (3), pp. 1147-1160.
Fulltext not available.
2011
2010
Ghorai, Prasanta,
Kraus, Anja,
Birnkammer, Tobias,
Geyer, Roland,
Bernhardt, Günther,
Dove, Stefan,
Seifert, Roland,
Elz, Sigurd and
Buschauer, Armin
(2010)
Chiral N(G)-acylated hetarylpropylguanidine-type histamine H2 receptor agonists do not show significant stereoselectivity.
Bioorganic & Medicinal Chemistry Letters 20 (10), pp. 3173-3176.
Fulltext not available.
2009
Igel, Patrick,
Schneider, Erich,
Schnell, David,
Elz, Sigurd,
Seifert, Roland and
Buschauer, Armin
(2009)
N(G)-Acylated imidazolylpropylguanidines as potent histamine H4 receptor agonists: selectivity by variation of the N(G)-substituent.
Journal of Medicinal Chemistry 52 (8), pp. 2623-2627.
Fulltext not available.
Kraus, Anja,
Ghorai, Prasanta,
Birnkammer, Tobias,
Schnell, David,
Elz, Sigurd,
Seifert, Roland,
Dove, Stefan,
Bernhardt, Günther and
Buschauer, Armin
(2009)
N(G)-Acylated aminothiazolylpropylguanidines as potent and selective histamine H2 receptor agonists.
ChemMedChem 4 (2), pp. 232-240.
Fulltext not available.
Mahboobi, Siavosh,
Dove, Stefan,
Sellmer, Andreas,
Winkler, Matthias,
Eichhorn, Emerich,
Pongratz, Herwig,
Ciossek, Thomas,
Baer, Thomas,
Maier, Thomas and
Beckers, Thomas
(2009)
Design of chimeric histone deacetylase- and tyrosine kinase-inhibitors: a series of imatinib hybrides as potent inhibitors of wild-type and mutant BCR-ABL, PDGF-Rbeta, and histone deacetylases.
Journal of medicinal chemistry 52 (8), pp. 2265-79.
Fulltext not available.
2008
Ghorai, Prasanta,
Kraus, Anja,
Keller, Max,
Götte, Carsten,
Igel, Patrick,
Schneider, Erich,
Schnell, David,
Bernhardt, Günther,
Dove, Stefan,
Zabel, Manfred,
Elz, Sigurd,
Seifert, Roland and
Buschauer, Armin
(2008)
Acylguanidines as bioisosteres of guanidines: N(G)-acylated imidazolylpropylguanidines, a new class of histamine H2 receptor agonists.
Journal of Medicinal Chemistry 51 (22), pp. 7193-7204.
Fulltext not available.
Mahboobi, Siavosh,
Sellmer, Andreas,
Eswayah, Asma,
Elz, Sigurd,
Uecker, Andrea and
Böhmer, Frank-D.
(2008)
Inhibition of PDGFR tyrosine kinase activity by a series of novel N-(3-(4-(pyridin-3-yl)-1H-imidazol-2-ylamino)phenyl)amides: a SAR study on the bioisosterism of pyrimidine and imidazole.
European journal of medicinal chemistry 43 (7), pp. 1444-1453.
Fulltext not available.
2007
Mahboobi, Siavosh,
Uecker, A.,
Cénac, C.,
Sellmer, A.,
Eichhorn, E.,
Elz, Sigurd,
Böhmer, F.-D. and
Dove, Stefan
(2007)
Inhibition of FLT3 and PDGFR tyrosine kinase activity by bis(benzo[b]furan-2-yl)methanones.
Bioorganic & medicinal chemistry 15 (5), pp. 2187-2197.
Fulltext not available.
2006
Xie, Sheng-Xue,
Kraus, Anja,
Ghorai, Prasanta,
Ye, Qi-Zhuang,
Elz, Sigurd,
Buschauer, Armin and
Seifert, Roland
(2006)
N1-(3-Cyclohexylbutanoyl)-N2-[3-(1H-imidazol-4-
yl)propyl]guanidine (UR-AK57), a Potent Partial Agonist for the Human Histamine H1- and H2- Receptors.
Journal of Pharmacology and Experimental Therapeutics 317 (3), pp. 1262-1268.
Fulltext restricted.
Mahboobi, Siavosh,
Uecker, A.,
Sellmer, A.,
Cénac, C.,
Höcher, H.,
Pongratz, H.,
Hufsky, H.,
Trümpler, A.,
Sicker, M.,
Heidel, F.,
Fischer, T.,
Stocking, C.,
Elz, Sigurd,
Böhmer, F.-D. and
Dove, Stefan
(2006)
Novel bis-(1H-indol-2-yl)-methanones as potent inhibitors of FLT3 and platelet-derived growth factor receptor tyrosine kinase.
Journal of Medicinal Chemistry 49 (11), pp. 3101-3115.
Fulltext not available.
2005
2004
2003
Li, Liantao,
Kracht, Julia,
Peng, Shiqi,
Bernhardt, Günther,
Elz, Sigurd and
Buschauer, Armin
(2003)
Synthesis and pharmacological activity of fluorescent histamine H2 receptor antagonists related to potentidine,.
Bioorganic & Medicinal Chemistry Letters 13 (10), 0960-894.
Fulltext not available.
Böhmer, F.D.,
Karagyozov, L.,
Uecker, A.,
Serve, H.,
Botzki, A.,
Mahboobi, Siavosh and
Dove, Stefan
(2003)
A single amino acid exchange inverts susceptibility of related receptor tyrosine kinases for the ATP-site inhibitor STI-571.
The Journal of Biological Chemistry 278 (7), pp. 5148-5155.
Fulltext not available.
Seifert, Roland,
Wenzel-Seifert, Katharina,
Bürckstümmer, Tilmann,
Pertz, Heinz H.,
Schunack, Walter,
Dove, Stefan,
Buschauer, Armin and
Elz, Sigurd
(2003)
Multiple differences in agonist and antagonist pharmacology between human and guinea pig histamine H1-receptor,.
Journal of Pharmacology and Experimental Therapeutics 305, pp. 1104-1115.
Fulltext not available.
2002
Mahboobi, Siavosh,
Teller, S.,
Pongratz, H.,
Hufsky, H.,
Sellmer, A.,
Botzki, Alexander,
Uecker, A.,
Beckers, T.,
Baasner, S.,
Schächtele, C.,
Überall, F.,
Kassack, M. U.,
Dove, Stefan and
Böhmer, F.-D.
(2002)
Bis(1H-2-indolyl)methanones as a novel class of inhibitors of the platelet-derived growth factor receptor kinase.
Journal of Medicinal Chemistry 45 (5), pp. 1002-1018.
Fulltext not available.
1999
1998
Mayer, Klaus K.,
Dove, Stefan,
Pongratz, Herwig,
Ertan, M. and
Wiegrebe, Wolfgang
(1998)
Electron impact induced fragmentation of 4-aryl-4,6,7,8-tetrahydro-1H,3H-quinazolinone-2,5-diones.
Heterocycles 48 (6), pp. 1169-1183.
Fulltext not available.
1997
Mahboobi, Siavosh,
Dove, Stefan,
Bednarski, P. J.,
Kuhr, S.,
Burgemeister, Thomas and
Schollmeyer, D.
(1997)
X-Ray Crystal Structure of Woodinine and Conformational Analysis by Means of Semiempirical and 1H-NMR Methods.
Journal of Natural Products-Copublished with the Am. Soc. of Pharmacognosy 60 (6), pp. 587-591.
Fulltext not available.
1994
1993
1992
Hirschfeld, Jürgen,
Buschauer, Armin,
Elz, Sigurd,
Schunack, Walter,
Ruat, Martial,
Traiffort, Elisabeth and
Schwartz, Jean-Charles
(1992)
Iodoaminopotentidine and related compounds: a new class of ligands with high affinity and selectivity for the histamine H_2-receptor.
Journal of Medicinal Chemistry 35, pp. 2231-2238.
Fulltext not available.
1988
1987
1986
Buschauer, Armin,
Schickaneder, Helmut,
Elz, Sigurd,
Schunack, Walter,
Szelenyi, Istvan,
Baumann, Gert and
Ahrens, K.-H.
(1986)
Guanidinderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel.
Patentanmeldung P 35 12 084.3 (2.4.1985), Offenlegungsschrift DE 35 12 084 A.
Fulltext not available.
1985
Schunack, Walter,
Buschauer, Armin,
Büyüktimkim, Servet,
Dziuron, Peter,
Elz, Sigurd,
Gerhardt, Günter,
Lebenstedt, Ernst,
Lennartz, Hans-Gerd,
Schwarz, Siegfried,
Spitzhoff, Margrit and
Steffens, Robert
(1985)
2. Histamine agonists - chemistry and structure-activity relationships.
In:
Dahlbom, R. and
Nilsson, J. L. G., (eds.)
VIIIth International Symposium on Medicinal Chemistry.
Swedish Pharmaceutical Press, Stockholm, pp. 169-182.
Fulltext not available.
Buschauer, Armin,
Schickaneder, Helmut,
Schunack, Walter,
Elz, Sigurd,
Szelenyi, Istvan,
Baumann, Gert and
Ahrens, K.-H.
(1985)
Imidazolylalkylguanidine, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel.
Patentanmeldung 85 114 205.9 (12.11.1985), Eur. Pat. Appl. EP 0 199 845 (5.11.1986).
Fulltext not available.
1984
1983
Elz, Sigurd,
Buschauer, Armin,
Dräger, M. and
Schunack, Walter
(1983)
Darstellung, Eigenschaften und Kristallstruktur der N-[2-(4,5,6,7-Tetrahydro-2-benzimidazolyl)ethyl]phthalamidsäure.
Z. Naturforsch. 38b, pp. 1203-1207.
Fulltext not available.
This list was generated on Tue Jan 19 12:51:24 2021 CET.