Number of items at this level: 166.
2025
Lier, Constantin,
Kees, Frieder 
,
Witowski, Andrea,
Rahmel, Tim,
Pockes, Steffen 
and
Dorn, Christoph 
(2025)
Simultaneous determination of ceftazidime and avibactam in patients by isocratic ion-pair liquid chromatography with photometric detection.
Journal of Chromatography Open 7, p. 100212.
2024
Scheuerer, Simon,
Motlova, Lucia,
Schäker-Hübner, Linda,
Sellmer, Andreas,
Feller, Felix,
Ertl, Fabian J.,
Koch, Pierre 
,
Hansen, Finn K.,
Barinka, Cyril and
Mahboobi, Siavosh 
(2024)
Biological and structural investigation of tetrahydro-β-carboline-based selective HDAC6 inhibitors with improved stability.
European Journal of Medicinal Chemistry 276, p. 116676.
2023
Nagl, Martin,
Moennich, Denise,
Rosier, Niklas 
,
Schihada, Hannes,
Sirbu, Alexei,
Konar, Nergis,
Reyes-Resina, Irene,
Navarro, Gemma,
Franco, Rafael,
Kolb, Peter,
Annibale, Paolo and
Pockes, Steffen 
(2023)
Fluorescent Tools for the Imaging of Dopamine D2‐Like Receptors.
ChemBioChem.
Rosier, Niklas 
,
Moennich, Denise,
Nagl, Martin,
Schihada, Hannes,
Sirbu, Alexei,
Konar, Nergis,
Reyes-Resina, Irene,
Navarro, Gemma,
Franco, Rafael,
Kolb, Peter,
Annibale, Paolo and
Pockes, Steffen 
(2023)
Shedding Light on the D1‐Like Receptors: A Fluorescence‐Based Toolbox for Visualization of the D1 and D5 Receptors.
ChemBioChem.
Cuellar, Matthew E.,
Yang, Mu 
,
Karavadhi, Surendra,
Zhang, Ya-Qin,
Zhu, Hu,
Sun, Hongmao,
Shen, Min,
Hall, Matthew D.,
Patnaik, Samarjit,
Ashe, Karen H.,
Walters, Michael A. 
and
Pockes, Steffen 
(2023)
An electrophilic fragment screening for the development of small molecules targeting caspase-2.
European Journal of Medicinal Chemistry 259, p. 115632.
Fulltext not available.
Jacob, Hannes,
Braekow, Pauline,
Hofmann, Britt,
Kirchhefer, Uwe,
Forster, Lisa,
Mönnich, Denise,
Humphrys, Laura J.,
Pockes, Steffen,
Neumann, Joachim and
Gergs, Ulrich
(2023)
Ergometrine stimulates histamine H2 receptors in the isolated human atrium.
Naunyn-Schmiedeberg's Archives of Pharmacology 396 (12), pp. 3809-3822.
Fulltext not available.
2022
Winkler, René 
,
Mägdefrau, Ann-Sophie,
Piskor, Eva-Maria,
Kleemann, Markus,
Beyer, Mandy,
Linke, Kevin,
Hansen, Lisa,
Schaffer, Anna-Maria 
,
Hoffmann, Marina E. 
,
Poepsel, Simon 
,
Heyd, Florian,
Beli, Petra,
Möröy, Tarik,
Mahboobi, Siavosh,
Krämer, Oliver H. and
Kosan, Christian
(2022)
Targeting the MYC interaction network in B-cell lymphoma via histone deacetylase 6 inhibition.
Oncogene 41 (40), pp. 4560-4572.
Singh, Gurpreet,
Liu, Peng,
Yao, Katherine R.,
Strasser, Jessica M.,
Hlynialuk, Chris,
Leinonen-Wright, Kailee,
Teravskis, Peter J.,
Choquette, Jessica M.,
Ikramuddin, Junaid,
Bresinsky, Merlin,
Nelson, Kathryn M.,
Liao, Dezhi,
Ashe, Karen H.,
Walters, Michael A. and
Pockes, Steffen
(2022)
Caspase-2 Inhibitor Blocks Tau Truncation and Restores Excitatory Neurotransmission in Neurons Modeling FTDP-17 Tauopathy.
ACS Chemical Neuroscience 13 (10), pp. 1549-1557.
Fulltext not available.
Beyer, Mandy,
Henninger, Sven J.,
Haehnel, Patricia S.,
Mustafa, Al-Hassan M. 
,
Gurdal, Ece 
,
Schubert, Bastian,
Christmann, Markus,
Sellmer, Andreas 
,
Mahboobi, Siavosh,
Drube, Sebastian,
Sippl, Wolfgang,
Kindler, Thomas and
Krämer, Oliver H.
(2022)
Identification of a highly efficient dual type I/II FMS-like tyrosine kinase inhibitor that disrupts the growth of leukemic cells.
Cell Chemical Biology 29 (3), 398-411.e4.
Fulltext not available.
Szczepańska, Katarzyna,
Podlewska, Sabina,
Dichiara, Maria,
Gentile, Davide,
Patamia, Vincenzo,
Rosier, Niklas,
Mönnich, Denise,
Ruiz Cantero, Ma Carmen,
Karcz, Tadeusz,
Łażewska, Dorota,
Siwek, Agata,
Pockes, Steffen,
Cobos, Enrique J.,
Marrazzo, Agostino,
Stark, Holger,
Rescifina, Antonio,
Bojarski, Andrzej J.,
Amata, Emanuele and
Kieć-Kononowicz, Katarzyna
(2022)
Structural and Molecular Insight into Piperazine and Piperidine Derivatives as Histamine H3 and Sigma-1 Receptor Antagonists with Promising Antinociceptive Properties.
ACS Chemical Neuroscience 13 (1), pp. 1-15.
Fulltext not available.
2021
Wachholz, Vanessa,
Mustafa, Al-Hassan M.,
Zeyn, Yanira,
Henninger, Sven J.,
Beyer, Mandy,
Dzulko, Melanie,
Piée-Staffa, Andrea,
Brachetti, Christina,
Haehnel, Patricia S.,
Sellmer, Andreas,
Mahboobi, Siavosh,
Kindler, Thomas,
Brenner, Walburgis,
Nikolova, Teodora and
Krämer, Oliver H.
(2021)
Inhibitors of class I HDACs and of FLT3 combine synergistically against leukemia cells with mutant FLT3.
Archives of Toxicology 96 (1), pp. 177-193.
Grätz, Lukas,
Laasfeld, Tõnis,
Allikalt, Anni 
,
Gruber, Corinna G.,
Pegoli, Andrea,
Tahk, Maris-Johanna,
Tsernant, Mari-Liis,
Keller, Max and
Rinken, Ago
(2021)
BRET- and fluorescence anisotropy-based assays for real-time monitoring of ligand binding to M2 muscarinic acetylcholine receptors.
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1868 (3), p. 118930.
Fulltext not available.
Gergs, Ulrich,
Büxel, Maren L.,
Bresinsky, Merlin,
Kirchhefer, Uwe,
Fehse, Charlotte,
Höring, Carina,
Hofmann, Britt,
Marušáková, Margaréta,
Čináková, Aneta,
Schwarz, Rebecca,
Pockes, Steffen 
and
Neumann, Joachim
(2021)
Cardiac Effects of Novel Histamine H2 Receptor Agonists.
Journal of Pharmacology and Experimental Therapeutics 379 (3), pp. 223-234.
Fulltext not available.
Szczepańska, Katarzyna 
,
Pockes, Steffen 
,
Podlewska, Sabina,
Höring, Carina,
Mika, Kamil,
Latacz, Gniewomir,
Bednarski, Marek,
Siwek, Agata 
,
Karcz, Tadeusz,
Nagl, Martin,
Bresinsky, Merlin,
Mönnich, Denise,
Seibel, Ulla,
Kuder, Kamil J. 
,
Kotańska, Magdalena,
Stark, Holger,
Elz, Sigurd and
Kieć-Kononowicz, Katarzyna
(2021)
Structural modifications in the distal, regulatory region of histamine H3 receptor antagonists leading to the identification of a potent anti-obesity agent.
European Journal of Medicinal Chemistry 213, p. 113041.
Fulltext not available.
2020
Grätz, Lukas,
Tropmann, Katharina,
Bresinsky, Merlin,
Müller, Christoph,
Bernhardt, Günther 
and
Pockes, Steffen
(2020)
NanoBRET binding assay for histamine H2 receptor ligands using live recombinant HEK293T cells.
Scientific Reports 10, p. 13288.
Sellmer, Andreas,
Pilsl, Bernadette,
Beyer, Mandy,
Pongratz, Herwig,
Wirth, Lukas,
Elz, Sigurd,
Dove, Stefan,
Henninger, Sven Julian,
Spiekermann, Karsten,
Polzer, Harald,
Klaeger, Susan,
Kuster, Bernhard,
Böhmer, Frank D.,
Fiebig, Heinz-Herbert,
Krämer, Oliver H. and
Mahboobi, Siavosh
(2020)
A series of novel aryl-methanone derivatives as inhibitors of FMS-like tyrosine kinase 3 (FLT3) in FLT3-ITD-positive acute myeloid leukemia.
European Journal of Medicinal Chemistry 193, p. 112232.
Fulltext not available.
Schihada, Hannes 
,
Ma, Xiaoyuan,
Zabel, Ulrike,
Vischer, Henry F.,
Schulte, Gunnar 
,
Leurs, Rob,
Pockes, Steffen 
and
Lohse, Martin J. 
(2020)
Development of a Conformational Histamine H3 Receptor Biosensor for the Synchronous Screening of Agonists and Inverse Agonists.
ACS Sensors 5 (6), pp. 1734-1742.
Fulltext not available.
2019
2018
Pockes, Steffen 
,
Wifling, David 
,
Keller, Max,
Buschauer, Armin 
and
Elz, Sigurd
(2018)
Highly Potent, Stable, and Selective Dimeric Hetarylpropylguanidine-Type Histamine H2 Receptor Agonists.
ACS Omega 2018 (3), pp. 2865-2882.
Leonhardt, Michel,
Sellmer, Andreas 
,
Krämer, Oliver H.,
Dove, Stefan,
Elz, Sigurd,
Kraus, Birgit,
Beyer, Mandy and
Mahboobi, Siavosh
(2018)
Design and biological evaluation of tetrahydro-β-carboline derivatives as highly potent histone deacetylase 6 (HDAC6) inhibitors.
European Journal of Medicinal Chemistry 152, pp. 329-357.
Fulltext not available.
Ridinger, Johannes,
Koeneke, Emily,
Kolbinger, Fiona R.,
Koerholz, Katharina,
Mahboobi, Siavosh,
Hellweg, Lars,
Gunkel, Nikolas,
Miller, Aubry K.,
Peterziel, Heike,
Schmezer, Peter,
Hamacher-Brady, Anne 
,
Witt, Olaf and
Oehme, Ina
(2018)
Dual role of HDAC10 in lysosomal exocytosis and DNA repair promotes neuroblastoma chemoresistance.
Scientific Reports 8 (1).
Fulltext not available.
Pons, Miriam,
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(2018)
Human platelet lysate as validated replacement for animal serum to assess chemosensitivity.
ALTEX.
Fulltext not available.
2017
Stojanovic, N.,
Hassan, Z.,
Wirth, M.,
Wenzel, P.,
Beyer, M.,
Schäfer, C.,
Brand, P.,
Kroemer, A.,
Stauber, R. H.,
Schmid, R. M.,
Arlt, A.,
Sellmer, A.,
Mahboobi, S.,
Rad, R.,
Reichert, M.,
Saur, D.,
Krämer, O. H. and
Schneider, G.
(2017)
HDAC1 and HDAC2 integrate the expression of p53 mutants in pancreatic cancer.
Oncogene 36 (13), pp. 1804-1815.
Fulltext not available.
Tsitsipatis, Dimitrios,
Jayavelu, Ashok Kumar,
Müller, Jörg P.,
Bauer, Reinhard,
Schmidt-Arras, Dirk,
Mahboobi, Siavosh,
Schnöder, Tina M.,
Heidel, Florian and
Böhmer, Frank D.
(2017)
Synergistic killing of FLT3ITD-positive AML cells by combined inhibition of tyrosine-kinase activity and N-glycosylation.
Oncotarget 8 (16).
Fulltext not available.
2016
Naporra, Franziska,
Gobleder, Susanne,
Wittmann, Hans-Joachim,
Spindler, Julia,
Bodensteiner, Michael,
Bernhardt, Günther,
Hübner, Harald,
Gmeiner, Peter,
Elz, Sigurd and
Strasser, Andrea
(2016)
Dibenzo[b,f][1,4]oxazepines and dibenzo[b,e]oxepines: Influence of the chlorine substitution pattern on the pharmacology at the H1R, H4R, 5-HT2AR and other selected GPCRs.
Pharmacological Research 113, pp. 610-625.
(In Press)
Fulltext not available.
Hammer, Sebastian,
Gobleder, Susanne,
Naporra, Franziska,
Wittmann, Hans-Joachim,
Elz, Sigurd,
Heinrich, Markus 
and
Strasser, Andrea
(2016)
2,4-Diaminopyrimidines as dual ligands at the histamine H1 and H4 receptor - H1/H4-receptor selectivity.
Bioorganic & Medicinal Chemistry Letters 26, pp. 292-300.
Fulltext not available.
Naporra, Franziska,
Gobleder, Susanne,
Wittmann, Hans-Joachim,
Spindler, Julia,
Bodensteiner, Michael,
Bernhardt, Günther,
Hübner, Harald,
Gmeiner, Peter 
,
Elz, Sigurd and
Strasser, Andrea
(2016)
Dibenzo[ b , f ][1,4]oxazepines and dibenzo[ b , e ]oxepines: Influence of the chlorine substitution pattern on the pharmacology at the H 1 R, H 4 R, 5-HT 2A R and other selected GPCRs.
Pharmacological Research 113, pp. 610-625.
Fulltext not available.
2015
Baumeister, Paul,
Erdmann, Daniela,
Biselli, Sabrina,
Kagermeier, Nicole,
Elz, Sigurd,
Bernhardt, Günther and
Buschauer, Armin
(2015)
3HUR-DE257: Development of a tritium-labeled squaramide-type selective histamine H2 receptor antagonist.
ChemMedChem 10 (1), pp. 83-93.
Fulltext not available.
2014
Darras, Fouad,
Pockes, Steffen,
Huang, Guozheng 
,
Wehle, Sarah,
Strasser, Andrea,
Wittmann, Hans-Joachim,
Nimczick, Martin,
Sotriffer, Christoph and
Decker, Michael
(2014)
Synthesis, biological evaluation, and computational studies of tri- and tetracyclic nitrogen-bridgehead compounds as potent dual-acting AChE inhibitors and hH3 receptor antagonists.
ACS Chemical Neuroscience 5 (3), pp. 225-242.
Fulltext not available.
Geyer, Roland,
Igel, Patrick,
Kaske, Melanie,
Elz, Sigurd and
Buschauer, Armin
(2014)
Synthesis, SAR and selectivity of 2-acyl- and 2-cyano-1-hetarylalkyl-guanidines at the four histamine receptor subtypes: a bioisosteric approach.
MedChemComm 5 (1), pp. 72-81.
Fulltext not available.
2013
Susanne Hopf, ,
Monika Bumel, ,
Michael Gruber, 
,
Thomas Bein, ,
Marcus Creutzenberg, ,
Bernhard Graf, and
Michael Pawlik,
(2013)
The Effect of Perchlorate Medication on Point-of-Care Testing.
Clinical Laboratory 59 (01+02/).
Fulltext not available.
2012
Birnkammer, Tobias,
Spickenreither, Anja,
Brunskole, Irena,
Lopuch, Miroslaw,
Kagermeier, Nicole,
Bernhardt, Günther,
Dove, Stefan,
Seifert, Roland,
Elz, Sigurd and
Buschauer, Armin
(2012)
The bivalent ligand approach leads to highly potent and selective acylguanidine-type histamine H2 receptor agonists.
Journal of Medicinal Chemistry 55 (3), pp. 1147-1160.
Fulltext not available.
Beckers, Thomas,
Mahboobi, Siavosh,
Sellmer, Andreas,
Winkler, Matthias,
Eichhorn, Emerich,
Pongratz, Herwig,
Maier, Thomas,
Ciossek, Thomas,
Baer, Thomas,
Kelter, Gerhard,
Fiebig, Heinz-Herbert and
Schmidt, Mathias
(2012)
Chimerically designed HDAC- and tyrosine kinase inhibitors. A series of erlotinib hybrids as dual-selective inhibitors of EGFR, HER2 and histone deacetylases.
MedChemComm 3 (7), p. 829.
Fulltext not available.
Appl, Heidrun,
Holzammer, Tobias,
Dove, Stefan,
Haen, Ekkehard,
Strasser, Andrea and
Seifert, Roland
(2012)
Interactions of recombinant human histamine H₁R, H₂R, H₃R, and H₄R receptors with 34 antidepressants and antipsychotics.
Naunyn-Schmiedeberg's archives of pharmacology 385 (2), pp. 145-170.
Fulltext not available.
Beckers, Thomas,
Sellmer, Andreas,
Eichhorn, Emerich,
Pongratz, Herwig,
Schächtele, Christoph,
Totzke, Frank,
Kelter, Gerhard,
Krumbach, Rebekka,
Fiebig, Heinz-Herbert,
Böhmer, Frank-D. and
Mahboobi, Siavosh
(2012)
Novel inhibitors of epidermal growth factor receptor: (4-(Arylamino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)(1H-indol-2-yl)methanones and (1H-indol-2-yl)(4-(phenylamino)thieno[2,3-d]pyrimidin-6-yl)methanones.
Bioorganic & Medicinal Chemistry 20 (1), pp. 125-136.
Fulltext not available.
2011
2010
Ghorai, Prasanta,
Kraus, Anja,
Birnkammer, Tobias,
Geyer, Roland,
Bernhardt, Günther,
Dove, Stefan,
Seifert, Roland,
Elz, Sigurd and
Buschauer, Armin
(2010)
Chiral N(G)-acylated hetarylpropylguanidine-type histamine H2 receptor agonists do not show significant stereoselectivity.
Bioorganic & Medicinal Chemistry Letters 20 (10), pp. 3173-3176.
Fulltext not available.
Uecker, Andrea,
Sicker, Marit,
Beckers, Thomas,
Mahboobi, Siavosh,
Hägerstrand, Daniel 
,
Östman, Arne and
Böhmer, Frank-D.
(2010)
Chimeric tyrosine kinase-HDAC inhibitors as antiproliferative agents.
Anti-Cancer Drugs 21 (8), pp. 759-765.
Fulltext not available.
Mahboobi, Siavosh,
Sellmer, Andreas,
Winkler, Matthias,
Eichhorn, Emerich,
Pongratz, Herwig,
Ciossek, Thomas,
Baer, Thomas,
Maier, Thomas and
Beckers, Thomas
(2010)
Novel Chimeric Histone Deacetylase Inhibitors: A Series of Lapatinib Hybrides as Potent Inhibitors of Epidermal Growth Factor Receptor (EGFR), Human Epidermal Growth Factor Receptor 2 (HER2), and Histone Deacetylase Activity.
Journal of Medicinal Chemistry 53 (24), pp. 8546-8555.
Fulltext not available.
Jandt, Enrico,
Mutschke, Oliver,
Mahboobi, Siavosh,
Uecker, Andrea,
Platz, Ronny,
Berndt, Alexander,
Böhmer, Frank-D.,
Figulla, Hans R. and
Werner, Gerald S.
(2010)
Stent-based release of a selective PDGF-receptor blocker from the bis-indolylmethanon class inhibits restenosis in the rabbit animal model.
Vascular Pharmacology 52 (1-2), pp. 55-62.
Fulltext not available.
2009
Igel, Patrick,
Schneider, Erich 
,
Schnell, David,
Elz, Sigurd,
Seifert, Roland and
Buschauer, Armin
(2009)
N(G)-Acylated imidazolylpropylguanidines as potent histamine H4 receptor agonists: selectivity by variation of the N(G)-substituent.
Journal of Medicinal Chemistry 52 (8), pp. 2623-2627.
Fulltext not available.
Romagnoli, Romeo,
Baraldi, Pier Giovanni,
Carrion, Maria Dora 
,
Cruz-Lopez, Olga,
Lopez Cara, Carlota,
Basso, Giuseppe,
Viola, Giampietro 
,
Khedr, Mohammed 
,
Balzarini, Jan,
Mahboobi, Siavosh,
Sellmer, Andreas,
Brancale, Andrea 
and
Hamel, Ernest
(2009)
2-Arylamino-4-Amino-5-Aroylthiazoles. “One-Pot” Synthesis and Biological Evaluation of a New Class of Inhibitors of Tubulin Polymerization.
Journal of Medicinal Chemistry 52 (17), pp. 5551-5555.
Fulltext not available.
Heidel, Florian,
Lipka, Daniel B.,
Mirea, Fian K.,
Mahboobi, Siavosh,
Grundler, Rebekka,
Kancha, Rama K.,
Duyster, Justus,
Naumann, Michael 
,
Huber, Christoph,
Böhmer, Frank D. and
Fischer, Thomas
(2009)
Bis(1H‐indol‐2‐yl)methanones are effective inhibitors of FLT3‐ITD tyrosine kinase and partially overcome resistance to PKC412A in vitro.
British Journal of Haematology 144 (6), pp. 865-874.
Fulltext not available.
Mahboobi, Siavosh,
Dove, Stefan,
Sellmer, Andreas,
Winkler, Matthias,
Eichhorn, Emerich,
Pongratz, Herwig,
Ciossek, Thomas,
Baer, Thomas,
Maier, Thomas and
Beckers, Thomas
(2009)
Design of chimeric histone deacetylase- and tyrosine kinase-inhibitors: a series of imatinib hybrides as potent inhibitors of wild-type and mutant BCR-ABL, PDGF-Rbeta, and histone deacetylases.
Journal of medicinal chemistry 52 (8), pp. 2265-79.
Fulltext not available.
2008
Mahboobi, Siavosh,
Eichhorn, Emerich,
Winkler, Matthias,
Sellmer, Andreas and
Möllmann, Ute
(2008)
Antibacterial activity of a novel series of 3-bromo-4-(1H-3-indolyl)-2,5-dihydro-1H-2,5-pyrroledione derivatives – An extended structure–activity relationship study.
European Journal of Medicinal Chemistry 43 (3), pp. 633-656.
Fulltext not available.
Mahboobi, Siavosh,
Sellmer, Andreas,
Eswayah, Asma,
Elz, Sigurd,
Uecker, Andrea and
Böhmer, Frank-D.
(2008)
Inhibition of PDGFR tyrosine kinase activity by a series of novel N-(3-(4-(pyridin-3-yl)-1H-imidazol-2-ylamino)phenyl)amides: a SAR study on the bioisosterism of pyrimidine and imidazole.
European journal of medicinal chemistry 43 (7), pp. 1444-1453.
Fulltext not available.
2007
Mahboobi, Siavosh,
Sellmer, Andreas,
Höcher, Heymo,
Garhammer, Christian,
Pongratz, Herwig,
Maier, Thomas,
Ciossek, Thomas and
Beckers, Thomas
(2007)
2-Aroylindoles and 2-Aroylbenzofurans with N-Hydroxyacrylamide Substructures as a Novel Series of Rationally Designed Histone Deacetylase Inhibitors.
Journal of Medicinal Chemistry 50 (18), pp. 4405-4418.
Fulltext not available.
Mahboobi, Siavosh,
Uecker, A.,
Cénac, C.,
Sellmer, A.,
Eichhorn, E.,
Elz, Sigurd,
Böhmer, F.-D. and
Dove, Stefan
(2007)
Inhibition of FLT3 and PDGFR tyrosine kinase activity by bis(benzo[b]furan-2-yl)methanones.
Bioorganic & medicinal chemistry 15 (5), pp. 2187-2197.
Fulltext not available.
Mahboobi, Siavosh,
Uecker, Andrea,
Cénac, Christophe,
Sellmer, Andreas,
Eichhorn, Emerich,
Elz, Sigurd,
Böhmer, Frank-D. and
Dove, Stefan
(2007)
Inhibition of FLT3 and PDGFR tyrosine kinase activity by bis(benzo[b]furan-2-yl)methanones.
Bioorganic & Medicinal Chemistry 15 (5), pp. 2187-2197.
Fulltext not available.
2006
Xie, Sheng-Xue,
Kraus, Anja,
Ghorai, Prasanta,
Ye, Qi-Zhuang,
Elz, Sigurd,
Buschauer, Armin and
Seifert, Roland
(2006)
N1-(3-Cyclohexylbutanoyl)-N2-[3-(1H-imidazol-4-
yl)propyl]guanidine (UR-AK57), a Potent Partial Agonist for the Human Histamine H1- and H2- Receptors.
Journal of Pharmacology and Experimental Therapeutics 317 (3), pp. 1262-1268.
Fulltext restricted.
Mahboobi, Siavosh,
Eichhorn, Emerich,
Popp, Alfred,
Sellmer, Andreas,
Elz, Sigurd and
Möllmann, Ute
(2006)
3-Bromo-4-(1H-3-indolyl)-2,5-dihydro-1H-2,5-pyrroledione derivatives as new lead compounds for antibacterially active substances.
European Journal of Medicinal Chemistry 41 (2), pp. 176-191.
Fulltext not available.
Guse, C.,
Koennings, S.,
Maschke, A.,
Hacker, M. 
,
Becker, C.,
Schreiner, S.,
Blunk, T.,
Spruss, T. and
Goepferich, A. 
(2006)
Biocompatibility and erosion behavior of implants made of triglycerides and blends with cholesterol and phospholipids.
International Journal of Pharmaceutics 314 (2), pp. 153-160.
Fulltext not available.
Mahboobi, Siavosh,
Uecker, Andrea,
Sellmer, Andreas,
Cénac, Christophe,
Höcher, Heymo,
Pongratz, Herwig,
Eichhorn, Emerich,
Hufsky, Harald,
Trümpler, Antje,
Sicker, Marit,
Heidel, Florian,
Fischer, Thomas,
Stocking, Carol,
Elz, Sigurd,
Böhmer, Frank-D. and
Dove, Stefan
(2006)
Novel Bis(1H-indol-2-yl)methanones as Potent Inhibitors of FLT3 and Platelet-Derived Growth Factor Receptor Tyrosine Kinase.
Journal of Medicinal Chemistry 49 (11), pp. 3101-3115.
Fulltext not available.
Mahboobi, Siavosh,
Uecker, A.,
Sellmer, A.,
Cénac, C.,
Höcher, H.,
Pongratz, H.,
Hufsky, H.,
Trümpler, A.,
Sicker, M.,
Heidel, F.,
Fischer, T.,
Stocking, C.,
Elz, Sigurd,
Böhmer, F.-D. and
Dove, Stefan
(2006)
Novel bis-(1H-indol-2-yl)-methanones as potent inhibitors of FLT3 and platelet-derived growth factor receptor tyrosine kinase.
Journal of Medicinal Chemistry 49 (11), pp. 3101-3115.
Fulltext not available.
2005
Mahboobi, Siavosh,
Sellmer, Andreas,
Eichhorn, Emerich,
Beckers, Thomas,
Fiebig, Heinz-Herbert and
Kelter, Gerhard
(2005)
Synthesis and cytotoxic activity of 2-acyl-1H-indole-4,7-diones on human cancer cell lines.
European Journal of Medicinal Chemistry 40 (1), pp. 85-92.
Fulltext not available.
2004
Welsh, Michael,
Welsh, Charlotte,
Ekman, Maria,
Dixelius, Johan,
Hägerkvist, Robert,
Anneren, Cecilia,
Åkerblom, Björn,
Mahboobi, Siavosh,
Chandrasekharan, Subhashini and
Liu, Edison T.
(2004)
The tyrosine kinase FRK/RAK participates in cytokine-induced islet cell cytotoxicity.
Biochemical Journal 382 (1), pp. 261-268.
Fulltext not available.
2003
Li, Liantao,
Kracht, Julia,
Peng, Shiqi,
Bernhardt, Günther,
Elz, Sigurd and
Buschauer, Armin
(2003)
Synthesis and pharmacological activity of fluorescent histamine H2 receptor antagonists related to potentidine,.
Bioorganic & Medicinal Chemistry Letters 13 (10), 0960-894.
Fulltext not available.
Böhmer, F. D.,
Karagyozov, L.,
Uecker, A.,
Serve, H.,
Botzki, A.,
Mahboobi, Siavosh and
Dove, Stefan
(2003)
A single amino acid exchange inverts susceptibility of related receptor tyrosine kinases for the ATP-site inhibitor STI-571.
The Journal of Biological Chemistry 278 (7), pp. 5148-5155.
Fulltext not available.
Iwasa, Kinuko,
Kuribayashi, Ayako,
Sugiura, Makiko,
Moriyasu, Masataka,
Lee, Dong-Ung and
Wiegrebe, Wolfgang
(2003)
LC–NMR and LC–MS analysis of 2,3,10,11-oxygenated protoberberine metabolites in Corydalis cell cultures.
Phytochemistry 64 (7), pp. 1229-1238.
Fulltext not available.
Seifert, Roland,
Wenzel-Seifert, Katharina,
Bürckstümmer, Tilmann,
Pertz, Heinz H.,
Schunack, Walter,
Dove, Stefan,
Buschauer, Armin and
Elz, Sigurd
(2003)
Multiple differences in agonist and antagonist pharmacology between human and guinea pig histamine H1-receptor,.
Journal of Pharmacology and Experimental Therapeutics 305, pp. 1104-1115.
Fulltext not available.
Menghin, Sonja,
Pertz, Heinz H.,
Kramer, Kai,
Seifert, Roland,
Schunack, Walter and
Elz, Sigurd
(2003)
Nα-Imidazolylalkyl and Pyridylalkyl Derivatives of Histaprodifen: Synthesis and in Vitro Evaluation of Highly Potent Histamine H1-Receptor Agonists.
Journal of Medicinal Chemistry 46 (25), pp. 5458-5470.
Fulltext not available.
Govoni, Marinella,
Bakker, Remko A.,
van de Wetering, Ineke,
Smit, Martine J.,
Menge, Wiro M. B. P.,
Timmerman, Henk,
Elz, Sigurd,
Schunack, Walter and
Leurs, Rob
(2003)
Synthesis and Pharmacological Identification of Neutral Histamine H1-Receptor Antagonists.
Journal of Medicinal Chemistry 46 (26), pp. 5812-5824.
Fulltext not available.
2002
Teller, S,
Krämer, D,
Böhmer, S-A,
Tse, KF,
Small, D,
Mahboobi, S,
Wallrapp, C,
Beckers, T,
Kratz-Albers, K,
Schwäble, J,
Serve, H and
Böhmer, F-D
(2002)
Bis(1H-2-indolyl)-1-methanones as inhibitors of the hematopoietic tyrosine kinase Flt3.
Leukemia 16 (8), pp. 1528-1534.
Fulltext not available.
Mahboobi, Siavosh,
Teller, Steffen,
Pongratz, Herwig,
Hufsky, Harald,
Sellmer, Andreas,
Botzki, Alexander 
,
Uecker, Andrea,
Beckers, Thomas,
Baasner, Silke,
Schächtele, Christoph,
Überall, Florian,
Kassack, Matthias U.,
Dove, Stefan and
Böhmer, Frank-D.
(2002)
Bis(1H-2-indolyl)methanones as a Novel Class of Inhibitors of the Platelet-Derived Growth Factor Receptor Kinase.
Journal of Medicinal Chemistry 45 (5), pp. 1002-1018.
Fulltext not available.
Mahboobi, Siavosh,
Teller, S.,
Pongratz, H.,
Hufsky, H.,
Sellmer, A.,
Botzki, Alexander,
Uecker, A.,
Beckers, T.,
Baasner, S.,
Schächtele, C.,
Überall, F.,
Kassack, M. U.,
Dove, Stefan and
Böhmer, F.-D.
(2002)
Bis(1H-2-indolyl)methanones as a novel class of inhibitors of the platelet-derived growth factor receptor kinase.
Journal of Medicinal Chemistry 45 (5), pp. 1002-1018.
Fulltext not available.
El-Subbagh, Hussein,
Wittig, Thomas,
Decker, Michael,
Elz, Sigurd,
Nieger, Martin 
and
Lehmann, Jochen
(2002)
Dopamine/Serotonin Receptor Ligands. Part IV [1]: Synthesis and Pharmacology of Novel 3-Benzazecines and 3-Benzazonines as Potential 5-HT2A and Dopamine Receptor Ligands.
Archiv der Pharmazie 335 (9), pp. 443-448.
Fulltext not available.
Sasse, Astrid 
,
Ligneau, Xavier,
Rouleau, Agnès,
Elz, Sigurd,
Ganellin, C. Robin,
Arrang, Jean-Michel,
Schwartz, Jean-Charles,
Schunack, Walter and
Stark, Holger 
(2002)
Influence of Bulky Substituents on Histamine H3Receptor Agonist/Antagonist Properties.
Journal of Medicinal Chemistry 45 (18), pp. 4000-4010.
Fulltext not available.
Graßmann, Sven,
Sadek, Bassem,
Ligneau, Xavier,
Elz, Sigurd,
Ganellin, C.Robin,
Arrang, Jean-Michel,
Schwartz, Jean-Charles,
Stark, Holger 
and
Schunack, Walter
(2002)
Progress in the proxifan class: heterocyclic congeners as novel potent and selective histamine H3-receptor antagonists.
European Journal of Pharmaceutical Sciences 15 (4), pp. 367-378.
Fulltext not available.
2001
de Martin, Rainer,
Mrowietz, Ulrich,
Wiegrebe, Wolfgang,
Jirovsky, David,
Loewe, Robert,
Pillinger, Manuela 
,
Gröger, Marion,
Holnthoner, Wolfgang,
Wolff, Klaus and
Petzelbauer, Peter
(2001)
Dimethylfumarate Inhibits Tumor-Necrosis-Factor-Induced CD62E Expression in an NF-κB-Dependent Manner.
Journal of Investigative Dermatology 117 (6), pp. 1363-1368.
Fulltext not available.
Iwasa, Kinuko,
Moriyasu, Masataka,
Yamori, Takao,
Turuo, Takashi,
Lee, Dong-Ung and
Wiegrebe, Wolfgang
(2001)
In Vitro Cytotoxicity of the Protoberberine-Type Alkaloids.
Journal of Natural Products 64 (7), pp. 896-898.
Fulltext not available.
Jirovsky, David,
Sellmer, Andreas,
Guiswe, Pierre,
Lemr, Karel 
and
Wiegrebe, Wolfgang
(2001)
On the Stereochemistry of Vincetene.
Monatshefte fuer Chemie/Chemical Monthly 132 (6), pp. 765-768.
Fulltext not available.
Vogelhuber, W.,
Rutunno, P.,
Magni, E.,
Gazzaniga, A. 
,
Spruss, Thilo,
Bernhardt, Günther,
Buschauer, Armin and
Goepferich, Achim
(2001)
Programmable biodegradable implants.
Journal of Controlled Release 73 (1), pp. 75-88.
Fulltext not available.
Iwasa, Kinuko,
Moriyasu, Masataka,
Tachibana, Yoko,
Kim, Hye-Sook,
Wataya, Yusuke,
Wiegrebe, Wolfgang,
Bastow, Kenneth F,
Cosentino, L.Mark,
Kozuka, Mutsuo and
Lee, Kuo-Hsiung
(2001)
Simple Isoquinoline and Benzylisoquinoline Alkaloids as Potential Antimicrobial, Antimalarial, Cytotoxic, and Anti-HIV Agents.
Bioorganic & Medicinal Chemistry 9 (11), pp. 2871-2884.
Fulltext not available.
Rostom, Sherif A. F.,
Farghaly, Ahmed M.,
Soliman, Farid S. G.,
El-Semary, Mona M.,
Elz, Sigurd and
Lehmann, Jochen
(2001)
Synthesis and 5-HT2A Antagonist Activity of Derivatives of the Novel Heterocycles Indolo[3,2-d]pyrrolo[3,2-g]azecine and Benzo[d]pyrrolo[3,2-g]azecine compared to the Benz[d]indolo[2,3-g]azecine Derivative LE 300.
Archiv der Pharmazie 334 (7), pp. 241-247.
Fulltext not available.
Mahboobi, Siavosh,
Pongratz, Herwig,
Hufsky, Harald,
Hockemeyer, Jörg,
Frieser, Markus,
Lyssenko, Alexei,
Paper, Dietrich H.,
Bürgermeister, Jutta,
Böhmer, Frank-D.,
Fiebig, Heinz-Herbert,
Burger, Angelika M.,
Baasner, Silke and
Beckers, Thomas
(2001)
Synthetic 2-Aroylindole Derivatives as a New Class of Potent Tubulin-Inhibitory, Antimitotic Agents.
Journal of Medicinal Chemistry 44 (26), pp. 4535-4553.
Fulltext not available.
2000
Schlemmer, Richard,
Spruß, Thilo,
Bernhardt, Günther and
Schönenberger, Helmut
(2000)
Does [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]- dichloroplatinum(II) act on the hormone-sensitive, murine breast cancer as a biological response modifier? Part 1: The MXT-M-3.2 breast cancer stimulates the growth of an identical second graft; [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplat inum (II) inhibits this process.
Archiv der Pharmazie 333 (2-3), pp. 69-71.
Fulltext not available.
Mahboobi, Siavosh,
Dechant, Irene,
Reindl, Hans,
Pongratz, Herwig,
Popp, Alfred and
Schollmeyer, Dieter
(2000)
Synthesis of bis(indolylmaleimide) macrocycles.
Journal of Heterocyclic Chemistry 37 (2), pp. 307-329.
Fulltext not available.
Mahboobi, Siavosh,
Eluwa, Stella,
Koller, Markus,
Popp, Alfred and
Schollmeyer, Dieter
(2000)
Synthesis of pyrrolo[3′,4′:2,3]azepino[4,5,6‐cd]indole‐8,10‐diones.
Journal of Heterocyclic Chemistry 37 (5), pp. 1177-1185.
Fulltext not available.
1999
1998
Mayer, Klaus K.,
Dove, Stefan,
Pongratz, Herwig,
Ertan, M. and
Wiegrebe, Wolfgang
(1998)
Electron impact induced fragmentation of 4-aryl-4,6,7,8-tetrahydro-1H,3H-quinazolinone-2,5-diones.
Heterocycles 48 (6), pp. 1169-1183.
Fulltext not available.
1997
Mahboobi, Siavosh,
Dove, Stefan,
Bednarski, P. J.,
Kuhr, S.,
Burgemeister, Thomas and
Schollmeyer, D.
(1997)
X-Ray Crystal Structure of Woodinine and Conformational Analysis by Means of Semiempirical and 1H-NMR Methods.
Journal of Natural Products-Copublished with the Am. Soc. of Pharmacognosy 60 (6), pp. 587-591.
Fulltext not available.
1994
1993
1992
Hirschfeld, Jürgen,
Buschauer, Armin,
Elz, Sigurd,
Schunack, Walter,
Ruat, Martial,
Traiffort, Elisabeth and
Schwartz, Jean-Charles
(1992)
Iodoaminopotentidine and related compounds: a new class of ligands with high affinity and selectivity for the histamine H_2-receptor.
Journal of Medicinal Chemistry 35, pp. 2231-2238.
Fulltext not available.
1988
1987
1986
Buschauer, Armin,
Schickaneder, Helmut,
Elz, Sigurd,
Schunack, Walter,
Szelenyi, Istvan,
Baumann, Gert and
Ahrens, K.-H.
(1986)
Guanidinderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel.
Patentanmeldung P 35 12 084.3 (2.4.1985), Offenlegungsschrift DE 35 12 084 A.
Fulltext not available.
1985
Schunack, Walter,
Buschauer, Armin,
Büyüktimkim, Servet,
Dziuron, Peter,
Elz, Sigurd,
Gerhardt, Günter,
Lebenstedt, Ernst,
Lennartz, Hans-Gerd,
Schwarz, Siegfried,
Spitzhoff, Margrit and
Steffens, Robert
(1985)
2. Histamine agonists - chemistry and structure-activity relationships.
In:
Dahlbom, R. and
Nilsson, J. L. G., (eds.)
VIIIth International Symposium on Medicinal Chemistry.
Swedish Pharmaceutical Press, Stockholm, pp. 169-182.
Fulltext not available.
Buschauer, Armin,
Schickaneder, Helmut,
Schunack, Walter,
Elz, Sigurd,
Szelenyi, Istvan,
Baumann, Gert and
Ahrens, K.-H.
(1985)
Imidazolylalkylguanidine, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel.
Patentanmeldung 85 114 205.9 (12.11.1985), Eur. Pat. Appl. EP 0 199 845 (5.11.1986).
Fulltext not available.
1984
1983
Elz, Sigurd,
Buschauer, Armin,
Dräger, M. and
Schunack, Walter
(1983)
Darstellung, Eigenschaften und Kristallstruktur der N-[2-(4,5,6,7-Tetrahydro-2-benzimidazolyl)ethyl]phthalamidsäure.
Z. Naturforsch. 38b, pp. 1203-1207.
Fulltext not available.
This list was generated on Mon May 19 16:25:05 2025 CEST.