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Recombinant expression, purification and characterization of human hyaluronidases

URN to cite this document:
urn:nbn:de:bvb:355-opus-7884
Hofinger, Edith
Date of publication of this fulltext: 10 May 2007 11:54


Abstract (English)

Hyaluronidases and their substrate, hyaluronic acid, are known to play a role in signal transduction events directly correlated with tumor growth and cell migration. Yet correlations with disease progression are controversial due to scarce information on enzymatic properties and the lack of specific inhibitors as pharmacological tools. Therefore, the aim of this thesis was the establishment of ...

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Translation of the abstract (German)

Hyaluronsäure und Hyaluronidasen spielen bei Signaltransduktionsprozessen eine Rolle, die mit der Zellmigration und dem Wachstum von Tumoren korrelieren. Allerdings liegen nur unzureichende Informationen über die enzymatischen Eigenschaften der Hyaluronidasen vor und es existieren keine geeigneten Inhibitoren als pharmakologische Werkzeuge. Daher war das Ziel dieser Arbeit die rekombinante ...

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