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New approaches to the therapy of glioblastoma: investigations on RNA interference, kinesin Eg5 and ABCB1/ABCG2 inhibition

Müller, Christine (2007) New approaches to the therapy of glioblastoma: investigations on RNA interference, kinesin Eg5 and ABCB1/ABCG2 inhibition. PhD, Universität Regensburg.

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Date of publication of this fulltext: 09 Jul 2007 12:00

Abstract (English)

No effective chemotherapy for the treatment of malignant brain tumors, especially glioblastoma, exists so far. Despite the progress in surgical techniques and advances in the irradiation treatment, the concomitant chemotherapy is essential for the prevention of relapse and of major importance for patient outcome. The introduction of temozolomide combined with radiation in clinical practice led to ...

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Translation of the abstract (German)

Trotz der Fortschritte in der Chirurgie und v.a. der Bestrahlungstechnik ist die Prognose für Patienten mit malignen Hirntumoren äußerst ungünstig. Für die Behandlung von Glioblastomen gibt es bisher noch keine effektive Chemotherapie. Daher werden neue Strategien zur Behandlung von Gehirntumoren dringend benötigt. Die Ziele dieser Arbeit waren die Untersuchung des TmHU Proteins auf dessen ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:8 July 2007
Referee:Prof. Dr. Armin Buschauer
Date of exam:22 June 2007
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Keywords:Glioblastom , Kinesin , Inhibitor , RNS , Transfektion , TmHU , RNAi , Kinesin Eg5 , ABCB1 , ABCG2 , TmHU , RNAi , Kinesin Eg5 , ABCB1 , ABCG2
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:10567
Owner only: item control page

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