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Statistical evaluation and biological interpretation of non-random abundance in the E. coli K-12 genome of tetra- and pentanucleotide sequences related to VSP DNA mismatch repair

Merkl, Rainer, Kröger, Manfred, Rice, Peter and Fritz, Hans Joachim (1992) Statistical evaluation and biological interpretation of non-random abundance in the E. coli K-12 genome of tetra- and pentanucleotide sequences related to VSP DNA mismatch repair. Nucleic Acids Research 20 (7), pp. 1657-1662.

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Date of publication of this fulltext: 16 Nov 2009 15:26

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Other URL: http://nar.oxfordjournals.org/cgi/content/abstract/20/7/1657, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC312252/?tool=pubmed


Abstract

The abundance of all tetra- and pentanucleotide sequences is calculated for a set of DNA sequence data comprising 767,393 nucleotides of the E. coli K-12 genome. Observed frequencies are compared to those expected from a Markov chain prediction algorithm. Systematic and extreme non-random representations are found for special sets of sequences. These are interpreted as arising from incorporation ...

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Item type:Article
Date:1992
Institutions:Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Rainer Merkl
Identification Number:
ValueType
1579456PubMed ID
Classification:
NotationType
AlgorithmsMESH
Bacillus subtilis/geneticsMESH
Base CompositionMESH
DNA Repair/genetics*MESH
DNA Replication/geneticsMESH
DNA, Bacterial/chemistryMESH
DNA, Bacterial/genetics*MESH
Escherichia coli/genetics*MESH
Genome, BacterialMESH
Markov ChainsMESH
Mutation/geneticsMESH
Repetitive Sequences, Nucleic Acid/genetics*MESH
Site-Specific DNA Methyltransferase (Cytosine-Specific)/geneticsMESH
Keywords:Algorithms Bacillus subtilis/genetics Base Composition DNA Repair/*genetics DNA Replication/genetics DNA, Bacterial/chemistry/*genetics Escherichia coli/*genetics Genome, Bacterial Markov Chains Mutation/genetics Repetitive Sequences, Nucleic Acid/*genetics Site-Specific DNA Methyltransferase (Cytosine-Specific)/genetics Support, Non-U.S. Gov't
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:No
Item ID:10926
Owner only: item control page

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