Anzahl der Einträge in dieser Kategorie: 94.
2022
2021
Hoffmeister, Helen,
Fuchs, Andreas ,
Komives, Elizabeth,
Groebner‐Ferreira, Regina,
Strobl, Laura,
Nazet, Julian,
Heizinger, Leonhard,
Merkl, Rainer,
Dove, Stefan und
Längst, Gernot
(2021)
Sequence and functional differences in the ATPase domains of CHD3 and SNF2H promise potential for selective regulability and drugability.
The FEBS Journal 288, S. 4000-4023.
Hertle, Regina,
Nazet, Julian,
Semmelmann, Florian,
Schlee, Sandra,
Funke, Franziska,
Merkl, Rainer und
Sterner, Reinhard
(2021)
Reprogramming the Specificity of a Protein Interface by Computational and Data-Driven Design.
Structure 29 (3), 292-304.e3.
Volltext nicht vorhanden.
2020
Simeth, Nadja Anita ,
Kinateder, Thomas,
Rajendran, Chitra,
Nazet, Julian,
Merkl, Rainer ,
Sterner, Reinhard ,
König, Burkhard und
Kneuttinger, Andrea C.
(2020)
Towards Photochromic Azobenzene‐Based Inhibitors for Tryptophan Synthase.
Chemistry—A European Journal 27, S. 2439-2451.
2019
Kneuttinger, Andrea C. ,
Zwisele, Stefanie,
Straub, Kristina ,
Bruckmann, Astrid,
Busch, Florian,
Kinateder, Thomas,
Gaim, Barbara,
Wysocki, Vicki H. ,
Merkl, Rainer und
Sterner, Reinhard
(2019)
Light-Regulation of Tryptophan Synthase by Combining Protein Design and Enzymology.
International Journal of Molecular Sciences 20 (20), S. 5106.
Ramchandran, Ramani,
Plössl, Karolina ,
Straub, Kristina,
Schmid, Verena,
Strunz, Franziska,
Wild, Jens ,
Merkl, Rainer,
Weber, Bernhard H. F. und
Friedrich, Ulrike
(2019)
Identification of the retinoschisin-binding site on the retinal Na/K-ATPase.
PLOS ONE 14 (5), e0216320.
Ziegler, Christian,
Graf, Johannes,
Faderl, Stefan,
Schedlbauer, Jessica,
Strieder, Nicholas,
Förstl, Bianca,
Spang, Rainer,
Bruckmann, Astrid,
Merkl, Rainer ,
Hombach, Sonja und
Kretz, Markus
(2019)
The long non-coding RNA LINC00941 and SPRR5 are novel regulators of human epidermal homeostasis.
EMBO Rep., e46612.
Volltext nicht vorhanden.
Semmelmann, Florian,
Kabeya, Naoki ,
Malcicka, Miriama,
Bruckmann, Astrid,
Broschwitz, Bastian,
Straub, Kristina,
Merkl, Rainer,
Monroig, Oscar,
Sterner, Reinhard,
Ruther, Joachim und
Ellers, Jacintha
(2019)
Functional characterisation of two Δ12-desaturases demonstrates targeted production of linoleic acid as pheromone precursor in Nasonia.
Journal of Experimental Biology.
Volltext nicht vorhanden.
Kneuttinger, Andrea C. ,
Straub, Kristina ,
Bittner, Philipp,
Simeth, Nadja Anita,
Bruckmann, Astrid,
Busch, Florian,
Rajendran, Chitra,
Hupfeld, Enrico,
Wysocki, Vicki H.,
Horinek, Dominik ,
König, Burkhard ,
Merkl, Rainer und
Sterner, Reinhard
(2019)
Light Regulation of Enzyme Allostery through Photo-responsive Unnatural Amino Acids.
Cell Chemical Biology 26, S. 1-14.
Volltext nicht vorhanden.
Straub, Kristina ,
Linde, Mona,
Kropp, Cosimo,
Blanquart, Samuel,
Babinger, Patrick und
Merkl, Rainer
(2019)
Sequence selection by FitSS4ASR alleviates ancestral sequence reconstruction as exemplified for geranylgeranylglyceryl phosphate synthase.
Biological Chemistry 400 (3), S. 367-381.
Volltext nicht vorhanden.
2018
Schwartz, Uwe,
Németh, Attila,
Diermeier, Sarah ,
Exler, Josef H.,
Hansch, Stefan,
Maldonado, Rodrigo,
Heizinger, Leonhard ,
Merkl, Rainer und
Längst, Gernot
(2018)
Characterizing the nuclease accessibility of DNA in human cells to map higher order structures of chromatin.
Nucleic Acids Research 2018 (1), S. 1-16.
Kneuttinger, Andrea C.,
Winter, Martin,
Simeth, Nadja Anita ,
Heyn, Kristina,
Merkl, Rainer ,
König, Burkhard und
Sterner, Reinhard
(2018)
Artificial Light Regulation of an Allosteric Bienzyme Complex by a Photosensitive Ligand.
ChemBioChem.
Volltext nicht vorhanden.
Rustler, Karin ,
Mickert, Matthias J. ,
Nazet, Julian,
Merkl, Rainer ,
Gorris, Hans H. und
König, Burkhard
(2018)
Development of photoswitchable inhibitors for β-galactosidase.
Organic & Biomolecular Chemistry 16, S. 7430-7437.
Volltext nicht vorhanden.
2017
2016
Busch, Florian,
Rajendran, Chitra,
Heyn, Kristina,
Schlee, Sandra,
Merkl, Rainer und
Sterner, Reinhard
(2016)
Ancestral Tryptophan Synthase Reveals Functional Sophistication of Primordial Enzyme Complexes.
Cell Chemical Biology 23 (6), S. 709-715.
Volltext nicht vorhanden.
2015
Ece, Selin,
Evran, Serap ,
Janda, Jan-Oliver,
Merkl, Rainer und
Sterner, Reinhard
(2015)
Improving thermal and detergent stability of Bacillus stearothermophilus neopullulanase by rational enzyme design.
Protein Engineering, Design and Selection 28 (6), S. 147-151.
Volltext nicht vorhanden.
2014
Diermeier, Sarah Daniela Helena ,
Kolovos, Petros ,
Heizinger, Leonhard,
Schwartz, Uwe,
Georgomanolis, Theodore,
Zirkel, Anne,
Wedemann, Gero ,
Grosveld, Frank,
Knoch, Tobias A.,
Merkl, Rainer,
Cook, Peter R.,
Längst, Gernot und
Papatonis, Argyris
(2014)
TNFα signalling primes chromatin for NF-κB binding and induces rapid and widespread nucleosome repositioning.
Genome Biology 15 (12).
Janda, Jan-Oliver,
Popal, Ajmal,
Bauer, Jochen,
Busch, Markus,
Klocke, Michael,
Spitzer, Wolfgang,
Keller, Jörg und
Merkl, Rainer
(2014)
H2rs: Deducing evolutionary and functionally important residue positions by means of an entropy and similarity based analysis of multiple sequence alignments.
BMC Bioinformatics 15 (118).
Reisinger, Bernd,
Sperl, Josef,
Holinski, Alexandra ,
Schmid, Veronika,
Rajendran, Chitra,
Carstensen, Linn,
Schlee, Sandra,
Blanquart, Samuel,
Merkl, Rainer und
Sterner, Reinhard
(2014)
Evidence for the Existence of Elaborate Enzyme Complexes in the Paleoarchean Era.
Journal of the American Chemical Society 136 (1), S. 122-129.
Volltext nicht vorhanden.
Reisinger, Bernd,
Kuzmanovic, Natascha,
Löffler, Patrick,
Merkl, Rainer ,
König, Burkhard und
Sterner, Reinhard
(2014)
Exploiting Protein Symmetry To Design Light-Controllable Enzyme Inhibitors.
Angewandte Chemie International Edition 53, S. 595-598.
Volltext nicht vorhanden.
Loedige, Inga,
Stotz, Mathias,
Qamar, Saadia,
Kramer, Katharina,
Hennig, Janosch,
Schubert, Thomas ,
Löffler, Patrick,
Längst, Gernot,
Merkl, Rainer ,
Urlaub, Henning und
Meister, Gunter
(2014)
The NHL domain of BRAT is an RNA-binding domain that directly contacts the hunchback mRNA for regulation.
Genes & Development 28 (7), S. 749-764.
Volltext nicht vorhanden.
2013
Hauptmann, Judith,
Dueck, Anne,
Harlander, Simone,
Pfaff, Janina,
Merkl, Rainer und
Meister, Gunter
(2013)
Turning catalytically inactive human Argonaute proteins into active slicer enzymes.
Nature Structural & Molecular Biology 20 (7), S. 814-817.
Volltext nicht vorhanden.
2012
Dietrich, Susanne,
Borst, Nadine,
Schlee, Sandra,
Schneider, Daniel,
Janda, Jan-Oliver,
Sterner, Reinhard und
Merkl, Rainer
(2012)
Experimental assessment of the importance of amino acid positions identified by an entropy-based correlation analysis of multiple sequence alignments.
Biochemistry.
Volltext nicht vorhanden.
Janda, Jan-Oliver,
Busch, Markus,
Kück, Fabian,
Porfenenko, Mikhail und
Merkl, Rainer
(2012)
CLIPS-1D: Analysis of multiple sequence alignments to deduce for residue-positions a role in catalysis, ligand-binding, or protein structure.
BMC Bioinformatics 13, S. 55.
Hain, Torsten,
Ghai, Rohit ,
Billion, Andre,
Kuenne, Carsten Tobias ,
Steinweg, Christiane,
Izar, Benjamin,
Mohamed, Walid,
Mraheil, Mobarak,
Domann, Eugen,
Schaffrath, Silke,
Kärst, Uwe,
Goesmann, Alexander ,
Oehm, Sebastian,
Pühler, Alfred,
Merkl, Rainer ,
Vorwerk, Sonja,
Glaser, Philippe,
Garrido, Patricia,
Rusniok, Christophe,
Buchrieser, Carmen ,
Goebel, Werner und
Chakraborty, Trinad
(2012)
Comparative genomics and transcriptomics of lineages I, II, and III strains of Listeria monocytogenes.
BMC genomics 13 (1), S. 144.
Peterhoff, David,
Zellner, Hermann,
Guldan, Harald,
Merkl, Rainer ,
Sterner, Reinhard und
Babinger, Patrick
(2012)
Dimerization determines substrate specificity of a bacterial prenyltransferase.
Chembiochem : a European journal of chemical biology 13 (9), S. 1297-1303.
Volltext nicht vorhanden.
2011
Zellner, H.,
Staudigel, M.,
Trenner, T.,
Bittkowski, M.,
Wolowski, V.,
Icking, C. und
Merkl, Rainer
(2011)
Prescont: Predicting protein-protein interfaces utilizing four residue properties.
Proteins.
Volltext nicht vorhanden.
Ohlmann, Andreas ,
Merkl, Rainer und
Tamm, Ernst R.
(2011)
Focus on Molecules: Norrin.
Experimental eye research.
Volltext nicht vorhanden.
Fischer, André,
Seitz, Tobias,
Lochner, Adriane,
Sterner, Reinhard,
Merkl, Rainer und
Bocola, Marco
(2011)
A Fast and Precise Approach for Computational Saturation Mutagenesis and its Experimental Validation by Using an Artificial (βα)8-Barrel Protein.
ChemBioChem.
Volltext nicht vorhanden.
2010
Felle, Max,
Exler, Josef H.,
Merkl, Rainer ,
Dachauer, Karoline,
Brehm, Alexander,
Grummt, Ingrid und
Längst, Gernot
(2010)
DNA sequence encoded repression of rRNA gene transcription in chromatin.
Nucleic acids research 38 (16), S. 5304-5314.
Volltext nicht vorhanden.
Richter, Markus,
Bosnali, Manal,
Carstensen, Linn,
Seitz, Tobias,
Durchschlag, Helmut,
Blanquart, Samuel,
Merkl, Rainer und
Sterner, Reinhard
(2010)
Computational and Experimental Evidence for the Evolution of a (betaalpha)(8)-Barrel Protein from an Ancestral Quarter-Barrel Stabilised by Disulfide Bonds.
J Mol Biol 398, S. 763-773.
Volltext nicht vorhanden.
Richter, Markus,
Bosnali, Manal,
Carstensen, Linn,
Seitz, Tobias,
Durchschlag, Helmut,
Blanquart, Samuel,
Merkl, Rainer und
Sterner, Reinhard
(2010)
Computational and Experimental Evidence for the Evolution of a (βα)8-Barrel Protein from an Ancestral Quarter-Barrel Stabilised by Disulfide Bonds.
Journal of Molecular Biology 398 (5), S. 763-773.
Volltext nicht vorhanden.
Wiedemann, Sonja M.,
Mildner, Silke N.,
Bönisch, Clemens,
Israel, Lars,
Maiser, Andreas ,
Matheisl, Sarah,
Straub, Tobias ,
Merkl, Rainer ,
Leonhardt, Heinrich,
Kremmer, Elisabeth,
Schermelleh, Lothar und
Hake, Sandra B.
(2010)
Identification and characterization of two novel primate-specific histone H3 variants, H3.X and H3.Y.
The Journal of cell biology 190 (5), S. 777-791.
Volltext nicht vorhanden.
2009
Fischer, André,
Enkler, Nils,
Neudert, Gerd,
Bocola, Marco,
Sterner, Reinhard und
Merkl, Rainer
(2009)
TransCent: computational enzyme design by transferring active sites and considering constraints relevant for catalysis.
BMC Bioinformatics 10, S. 54.
2008
Sterner, Reinhard,
Merkl, Rainer und
Raushel, Frank M.
(2008)
Computational design of enzymes.
Chemistry & Biology 15 (5), S. 421-423.
Volltext nicht vorhanden.
2007
Fink, Florian,
Merkl, Rainer und
Gronwald, Wolfram
(2007)
Verification of protein-protein interactions by use of docking techniques.
In:
Hansmann, U. H. E. und
Meinke, J. Mohanty S. und
Zimmermann, O., (eds.)
From computational biophysics to systems biology (CBSB07). Proceedings of the NIC Workshop 2007.
NIC Series, 36.
John von Neumann Institute for Computing, Jülich, S. 125-127.
ISBN 978-3-9810843-2-0.
2006
Waack, Stephan,
Keller, Oliver,
Asper, Roman,
Brodag, Thomas,
Damm, Carsten,
Fricke, Wolfgang Florian ,
Surovcik, Katharina,
Meinicke, Peter und
Merkl, Rainer
(2006)
Score-based prediction of genomic islands in prokaryotic genomes using hidden Markov models.
BMC Bioinformatics 7, S. 142.
2005
2004
Veith, Birgit,
Herzberg, Christina,
Steckel, Silke,
Feesche, Jörg,
Maurer, Karl Heinz,
Ehrenreich, Petra,
Bäumer, Sebastian,
Henne, Anke,
Liesegang, Heiko,
Merkl, Rainer,
Ehrenreich, Armin und
Gottschalk, Gerhard
(2004)
The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential.
Journal of Molecular Microbiology and Biotechnology 7 (4), S. 204-211.
Zugang zum Volltext eingeschränkt.
2003
Brüggemann, Holger,
Baumer, Sebastian,
Fricke, Wolfgang Florian,
Wiezer, Arnim,
Liesegang, Heiko,
Decker, Ivona,
Herzberg, Christina,
Martinez-Arias, Rosa,
Merkl, Rainer,
Henne, Anke und
Gottschalk, Gerhard
(2003)
The genome sequence of Clostridium tetani, the causative agent of tetanus disease.
Proceedings of the National Academy of Sciences of the United States of America (PNAS) ISSN 1091-6490.
Wiezer, Arnim und
Merkl, Rainer
(2003)
secureBLAST.
In Silico Biology 3 (4), 0033.
Volltext nicht vorhanden.
2002
Merkl, Rainer und
Waack, Stephan
(2002)
Bioinformatik Interaktiv.
Wiley-VCH, Weinheim.
ISBN 78-3-527-30662-6.
Volltext nicht vorhanden.
Larbig, Karen D.,
Christmann, Andreas,
Johann, André,
Klockgether, Jens,
Hartsch, Thomas,
Merkl, Rainer,
Wiehlmann, Lotz,
Fritz, Hans Joachim und
Tümmler, Burkhard
(2002)
Gene Islands Integrated into tRNA(Gly) Genes Confer Genome Diversity on a Pseudomonas aeruginosa Clone.
Journal of Bacteriology 184 (23), S. 6665-6680.
Deppenmeier, Uwe,
Johann, André,
Hartsch, Thomas,
Merkl, Rainer,
Schmitz, Ruth A:,
Martinez-Arias, Rosa,
Henne, Anke,
Wiezer, Arnim,
Bäumer, Sebastian,
Jacobi, Carsten,
Brüggemann, Holger,
Lienard, Tanja,
Christmann, Andreas,
Bömeke, Mechthild,
Steckel, Silke,
Bhattacharyya, Anamitra,
Lykidis, Athanasios,
Overbeek, Ross,
Klenk, Hans Peter,
Gunsalus, Robert P.,
Fritz, Hans Joachim und
Gottschalk, Gerhard
(2002)
The genome of Methanosarcina mazei: evidence for lateral gene transfer between bacteria and archaea.
Journal of Molecular Microbiology and Biotechnology 4 (4), S. 453-461.
Volltext nicht vorhanden.
1996
1995
1992
Sander, Chris,
Vriend, Gerrit,
Bazan, Fernando,
Horovitz, Amnon,
Nakamura, Haruki,
Ribas, Luis,
Finkelstein, Alexei V.,
Lockhart, Andrew,
Merkl, Rainer,
Perry, L. Jeanne,
Emery, Stephen C.,
Gaboriaud, Christine,
Marks, Cara,
Moult, John,
Verlinde, Christophe,
Eberhard, Marc,
Elofsson, Arne,
Hubbard, Tim J. P.,
Regan, Lynne,
Banks, Jay,
Jappelli, Roberto,
Lesk, Arthur M. und
Tramontano, Anna
(1992)
Protein design on computers. Five new proteins: Shpilka, Grendel, Fingerclasp, Leather, and Aida.
Proteins 12 (2), S. 105-110.
Volltext nicht vorhanden.
1991
1989
Fahn, H.,
Maubach, P.,
Merkl, Rainer,
Senner, H.,
Hellwig, H. und
Wirtzfeld, A.
(1989)
[Ultra-high dose thrombolytic therapy with streptokinase in peripheral venous thrombosis].
Medizinische Klinik 84 (4), 183-7, 226.
Volltext nicht vorhanden.
1987
1985
Noegel, A.,
Harloff, C.,
Hirth, P.,
Merkl, Rainer,
Modersitzki, M.,
Stadler, J.,
Weinhart, U.,
Westphal, M. und
Gerisch, G.
(1985)
Probing an adhesion mutant of Dictyostelium discoideum with cDNA clones and monoclonal antibodies indicates a specific defect in the contact site A glycoprotein.
EMBO Journal 4 (13B), S. 3805-3810.
1984
1983
1982
Ochiai, H.,
Stadler, J.,
Westphal, M.,
Wagle, G.,
Merkl, Rainer und
Gerisch, G.
(1982)
Monoclonal antibodies against contact sites A of Dictyostelium discoideum: detection of modifications of the glycoprotein in tunicamycin-treated cells.
EMBO Journal 1 (8), S. 1011-1016.
Ochiai, H.,
Schwarz, H.,
Merkl, Rainer,
Wagle, G. und
Gerisch, G.
(1982)
Stage-specific antigens reacting with monoclonal antibodies against contact site A, a cell-surface glycoprotein of Dictyostelium discoideum.
Cell Differentiation 11 (1), S. 1-13.
Zugang zum Volltext eingeschränkt.
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