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Kinateder, Thomas
, Drexler, Lukas, Straub, Kristina
, Merkl, Rainer
and Sterner, Reinhard
(2022)
Experimental and computational analysis of the ancestry of an evolutionary young enzyme from histidine biosynthesis.
Protein Science 32 (1), e4536.
Nazet, Julian Simon
(2022)
Design of Protein Interfaces Using Computer-Based Methods.
PhD, Universität Regensburg.
Heizinger, Leonhard Josef
(2021)
Exploring Early Stages of Protein Evolution.
PhD, Universität Regensburg.
Heizinger, Leonhard and Merkl, Rainer
(2021)
Evidence for the preferential reuse of sub‐domain motifs in primordial protein folds.
Proteins: Structure, Function, and Bioinformatics 89, pp. 1167-1179.
Hoffmeister, Helen, Fuchs, Andreas
, Komives, Elizabeth, Groebner‐Ferreira, Regina, Strobl, Laura, Nazet, Julian, Heizinger, Leonhard, Merkl, Rainer, Dove, Stefan and Längst, Gernot
(2021)
Sequence and functional differences in the ATPase domains of CHD3 and SNF2H promise potential for selective regulability and drugability.
The FEBS Journal 288, pp. 4000-4023.
and Sterner, Reinhard
(2021)
Reprogramming the Specificity of a Protein Interface by Computational and Data-Driven Design.
Structure 29 (3), 292-304.e3.
Fulltext not available.
, Schmitz, Samuel, Ertelt, Moritz
, Merkl, Rainer
and Meiler, Jens
(2021)
Rosetta design with co-evolutionary information retains protein function.
PLOS Computational Biology 17 (1), e1008568.
Fulltext not available.
Simeth, Nadja Anita
, Kinateder, Thomas, Rajendran, Chitra, Nazet, Julian, Merkl, Rainer
, Sterner, Reinhard
, König, Burkhard
and Kneuttinger, Andrea C.
(2020)
Towards Photochromic Azobenzene‐Based Inhibitors for Tryptophan Synthase.
Chemistry—A European Journal 27, pp. 2439-2451.
Esch, Robert and Merkl, Rainer
(2020)
Conserved genomic neighborhood is a strong but no perfect indicator for a direct interaction of microbial gene products.
BMC Bioinformatics 21 (1), pp. 1-8.
Kneuttinger, Andrea C.
, Zwisele, Stefanie, Straub, Kristina
, Bruckmann, Astrid, Busch, Florian, Kinateder, Thomas, Gaim, Barbara, Wysocki, Vicki H.
, Merkl, Rainer
and Sterner, Reinhard
(2019)
Light-Regulation of Tryptophan Synthase by Combining Protein Design and Enzymology.
International Journal of Molecular Sciences 20 (20), p. 5106.
Straub, Kristina
(2019)
Ancestral Sequence Reconstruction: Methods and Applications.
PhD, Universität Regensburg.
Ramchandran, Ramani, Plössl, Karolina
, Straub, Kristina, Schmid, Verena, Strunz, Franziska, Wild, Jens
, Merkl, Rainer, Weber, Bernhard H. F. and Friedrich, Ulrike
(2019)
Identification of the retinoschisin-binding site on the retinal Na/K-ATPase.
PLOS ONE 14 (5), e0216320.
, Hombach, Sonja and Kretz, Markus
(2019)
The long non-coding RNA LINC00941 and SPRR5 are novel regulators of human epidermal homeostasis.
EMBO Rep., e46612.
Fulltext not available.
(2019)
A Fold-Independent Interface Residue Is Crucial for Complex Formation and Allosteric Signaling in Class I Glutamine Amidotransferases.
Biochemistry 58 (22), pp. 2584-2588.
Fulltext not available.
, Malcicka, Miriama, Bruckmann, Astrid, Broschwitz, Bastian, Straub, Kristina, Merkl, Rainer, Monroig, Oscar, Sterner, Reinhard, Ruther, Joachim
and Ellers, Jacintha
(2019)
Functional characterisation of two Δ12-desaturases demonstrates targeted production of linoleic acid as pheromone precursor in Nasonia.
Journal of Experimental Biology.
Fulltext not available.
, Straub, Kristina
, Bittner, Philipp, Simeth, Nadja Anita, Bruckmann, Astrid, Busch, Florian, Rajendran, Chitra, Hupfeld, Enrico, Wysocki, Vicki H., Horinek, Dominik
, König, Burkhard
, Merkl, Rainer and Sterner, Reinhard
(2019)
Light Regulation of Enzyme Allostery through Photo-responsive Unnatural Amino Acids.
Cell Chemical Biology 26, pp. 1-14.
Fulltext not available.
, Linde, Mona, Kropp, Cosimo, Blanquart, Samuel, Babinger, Patrick
and Merkl, Rainer
(2019)
Sequence selection by FitSS4ASR alleviates ancestral sequence reconstruction as exemplified for geranylgeranylglyceryl phosphate synthase.
Biological Chemistry 400 (3), pp. 367-381.
Fulltext not available.
Schwartz, Uwe, Németh, Attila, Diermeier, Sarah
, Exler, Josef H., Hansch, Stefan, Maldonado, Rodrigo, Heizinger, Leonhard
, Merkl, Rainer
and Längst, Gernot
(2018)
Characterizing the nuclease accessibility of DNA in human cells to map higher order structures of chromatin.
Nucleic Acids Research 2018 (1), pp. 1-16.
, Heyn, Kristina, Merkl, Rainer
, König, Burkhard
and Sterner, Reinhard
(2018)
Artificial Light Regulation of an Allosteric Bienzyme Complex by a Photosensitive Ligand.
ChemBioChem.
Fulltext not available.
, Mickert, Matthias J.
, Nazet, Julian, Merkl, Rainer
, Gorris, Hans H.
and König, Burkhard
(2018)
Development of photoswitchable inhibitors for β-galactosidase.
Organic & Biomolecular Chemistry 16, pp. 7430-7437.
Fulltext not available.
Löffler, Patrick
(2017)
Computationally modeling interactions and dynamics to promote the understanding of protein function.
PhD, Universität Regensburg.
Merkl, Rainer, Löffler, Patrick
, Schmitz, Samuel, Hupfeld, Enrico and Sterner, Reinhard
(2017)
Rosetta:MSF: a modular framework for multi-state computational protein design.
PLOS Computational Biology 13 (6), e1005600.
Kandlinger, Florian, Plach, Maximilian G. and Merkl, Rainer
(2017)
AGeNNT: annotation of enzyme families by means of refined neighborhood networks.
BMC Bioinformatics 18 (1), pp. 1-13.
Merkl, Rainer, Verprinsky, Valery, Plach, Maximilian G. and Heizinger, Leonhard
(2017)
Assessing in silico the recruitment and functional spectrum of bacterial enzymes from secondary metabolism.
BMC Evolutionary Biology 17 (36), pp. 1-15.
Merkl, Rainer, Plach, Maximilian G., Reisinger, Bernd and Sterner, Reinhard
(2016)
Long-Term Persistence of Bi-functionality Contributes to the Robustness of Microbial Life through Exaptation.
PLoS Genetics 12 (1), pp. 1-14.
and Sterner, Reinhard
(2016)
Ancestral Tryptophan Synthase Reveals Functional Sophistication of Primordial Enzyme Complexes.
Cell Chemical Biology 23 (6), pp. 709-715.
Fulltext not available.
Merkl, Rainer, Žváček, Clemens, Heizinger, Leonhard
and Friedrichs, Gerald
(2015)
An assessment of catalytic residue 3D ensembles for the prediction of enzyme function.
BMC Bioinformatics 16 (359), pp. 1-8.
, Janda, Jan-Oliver, Merkl, Rainer
and Sterner, Reinhard
(2015)
Improving thermal and detergent stability of Bacillus stearothermophilus neopullulanase by rational enzyme design.
Protein Engineering, Design and Selection 28 (6), pp. 147-151.
Fulltext not available.
Diermeier, Sarah Daniela Helena
, Kolovos, Petros
, Heizinger, Leonhard, Schwartz, Uwe, Georgomanolis, Theodore, Zirkel, Anne, Wedemann, Gero
, Grosveld, Frank, Knoch, Tobias A., Merkl, Rainer, Cook, Peter R., Längst, Gernot and Papatonis, Argyris
(2014)
TNFα signalling primes chromatin for NF-κB binding and induces rapid and widespread nucleosome repositioning.
Genome Biology 15 (12).
Janda, Jan-Oliver
(2014)
Data mining for important amino acid residues in multiple sequence alignments and protein structures.
PhD, Universität Regensburg.
Janda, Jan-Oliver, Popal, Ajmal, Bauer, Jochen, Busch, Markus, Klocke, Michael, Spitzer, Wolfgang, Keller, Jörg and Merkl, Rainer
(2014)
H2rs: Deducing evolutionary and functionally important residue positions by means of an entropy and similarity based analysis of multiple sequence alignments.
BMC Bioinformatics 15 (118).
, Schmid, Veronika, Rajendran, Chitra, Carstensen, Linn, Schlee, Sandra, Blanquart, Samuel, Merkl, Rainer
and Sterner, Reinhard
(2014)
Evidence for the Existence of Elaborate Enzyme Complexes in the Paleoarchean Era.
Journal of the American Chemical Society 136 (1), pp. 122-129.
Fulltext not available.
, König, Burkhard
and Sterner, Reinhard
(2014)
Exploiting Protein Symmetry To Design Light-Controllable Enzyme Inhibitors.
Angewandte Chemie International Edition 53, pp. 595-598.
Fulltext not available.
and Meister, Gunter
(2014)
Generation of catalytic human Ago4 identifies structural elements important for RNA cleavage.
RNA 20 (10), pp. 1532-1538.
Fulltext not available.
, Löffler, Patrick, Längst, Gernot, Merkl, Rainer
, Urlaub, Henning and Meister, Gunter
(2014)
The NHL domain of BRAT is an RNA-binding domain that directly contacts the hunchback mRNA for regulation.
Genes & Development 28 (7), pp. 749-764.
Fulltext not available.
Birzer, Dietmar
(2013)
Entwicklung von Enzymdesignalgorithmen mit flexibler Ligandenpositionierung.
PhD, Universität Regensburg.
(2013)
CLIPS-4D: a classifier that distinguishes structurally and functionally important residue-positions based on sequence and 3D data.
Bioinformatics 29 (23), pp. 3029-3035.
Fulltext not available.
and Meister, Gunter
(2013)
Turning catalytically inactive human Argonaute proteins into active slicer enzymes.
Nature Structural & Molecular Biology 20 (7), pp. 814-817.
Fulltext not available.
and Merkl, Rainer
(2012)
Experimental assessment of the importance of amino acid positions identified by an entropy-based correlation analysis of multiple sequence alignments.
Biochemistry.
Fulltext not available.
Zellner, Hermann Josef
(2012)
PresCont: Vorhersage von Protein-Protein Interaktionsflächen unter Verwendung struktureller und evolutionärer Eigenschaften.
PhD, Universität Regensburg.
Janda, Jan-Oliver, Busch, Markus, Kück, Fabian, Porfenenko, Mikhail and Merkl, Rainer
(2012)
CLIPS-1D: Analysis of multiple sequence alignments to deduce for residue-positions a role in catalysis, ligand-binding, or protein structure.
BMC Bioinformatics 13, p. 55.
Hain, Torsten, Ghai, Rohit
, Billion, Andre, Kuenne, Carsten Tobias
, Steinweg, Christiane, Izar, Benjamin, Mohamed, Walid, Mraheil, Mobarak, Domann, Eugen, Schaffrath, Silke, Kärst, Uwe, Goesmann, Alexander
, Oehm, Sebastian, Pühler, Alfred, Merkl, Rainer
, Vorwerk, Sonja, Glaser, Philippe, Garrido, Patricia, Rusniok, Christophe, Buchrieser, Carmen
, Goebel, Werner and Chakraborty, Trinad
(2012)
Comparative genomics and transcriptomics of lineages I, II, and III strains of Listeria monocytogenes.
BMC genomics 13 (1), p. 144.
, Sterner, Reinhard
and Babinger, Patrick
(2012)
Dimerization determines substrate specificity of a bacterial prenyltransferase.
Chembiochem : a European journal of chemical biology 13 (9), pp. 1297-1303.
Fulltext not available.
(2011)
Prescont: Predicting protein-protein interfaces utilizing four residue properties.
Proteins.
Fulltext not available.
, Merkl, Rainer
and Tamm, Ernst R.
(2011)
Focus on Molecules: Norrin.
Experimental eye research.
Fulltext not available.
and Gronwald, Wolfram
(2011)
PROCOS: Computational analysis of protein–protein complexes.
Journal of Computational Chemistry 32 (12), pp. 2575-2586.
Fulltext not available.
and Bocola, Marco
(2011)
A Fast and Precise Approach for Computational Saturation Mutagenesis and its Experimental Validation by Using an Artificial (βα)8-Barrel Protein.
ChemBioChem.
Fulltext not available.
Dietrich, Susanne
(2011)
Mutationsanalyse und kinetische Untersuchungen zum Reaktionsmechanismus der Indolglycerinphosphat-Synthase aus Sulfolobus solfataricus.
PhD, Universität Regensburg.
von Mandach, Conrad and Merkl, Rainer
(2010)
Genes optimized by evolution for accurate and fast translation encode in Archaea and Bacteria a broad and characteristic spectrum of protein functions.
BMC genomics 11 (1), p. 617.
, Dachauer, Karoline, Brehm, Alexander, Grummt, Ingrid and Längst, Gernot
(2010)
DNA sequence encoded repression of rRNA gene transcription in chromatin.
Nucleic acids research 38 (16), pp. 5304-5314.
Fulltext not available.
and Sterner, Reinhard
(2010)
Computational and Experimental Evidence for the Evolution of a (βα)8-Barrel Protein from an Ancestral Quarter-Barrel Stabilised by Disulfide Bonds.
Journal of Molecular Biology 398 (5), pp. 763-773.
Fulltext not available.
, Matheisl, Sarah, Straub, Tobias
, Merkl, Rainer
, Leonhardt, Heinrich, Kremmer, Elisabeth, Schermelleh, Lothar
and Hake, Sandra B.
(2010)
Identification and characterization of two novel primate-specific histone H3 variants, H3.X and H3.Y.
The Journal of cell biology 190 (5), pp. 777-791.
Fulltext not available.
and Wiezer, Arnim
(2009)
GO4genome: A prokaryotic phylogeny based on genome organisation.
Journal of Molecular Evolution 68 (5), pp. 550-562.
Fulltext not available.
Fischer, André, Enkler, Nils, Neudert, Gerd, Bocola, Marco, Sterner, Reinhard
and Merkl, Rainer
(2009)
TransCent: computational enzyme design by transferring active sites and considering constraints relevant for catalysis.
BMC Bioinformatics 10, p. 54.
Fischer, André
(2008)
TRANSCENT - ein Enzymdesignprogramm zum Transfer aktiver Zentren unter Wahrung Katalyse-relevanter Rahmenbedingungen.
PhD, Universität Regensburg.
Merkl, Rainer
and Zwick, Matthias
(2007)
H2r: Identification of evolutionary important residues by means of an entropy based analysis of multiple sequence alignments.
BMC Bioinformatics 9, p. 151.
Merkl, Rainer
(2007)
Modelling the evolution of the archeal tryptophan synthase.
BMC Evolutionary Biology 7, p. 59.
Fink, Florian, Merkl, Rainer and Gronwald, Wolfram
(2007)
Verification of protein-protein interactions by use of docking techniques.
In: Hansmann, U. H. E. and Meinke, J. Mohanty S. and Zimmermann, O., (eds.)
From computational biophysics to systems biology (CBSB07). Proceedings of the NIC Workshop 2007.
NIC Series, 36.
John von Neumann Institute for Computing, Jülich, pp. 125-127.
ISBN 978-3-9810843-2-0.
(2006)
A comparative categorization of protein function encoded in bacterial or archeal genomic islands.
J Mol Evol 62 (1), pp. 1-14.
Fulltext not available.
Waack, Stephan, Keller, Oliver, Asper, Roman, Brodag, Thomas, Damm, Carsten, Fricke, Wolfgang Florian
, Surovcik, Katharina, Meinicke, Peter and Merkl, Rainer
(2006)
Score-based prediction of genomic islands in prokaryotic genomes using hidden Markov models.
BMC Bioinformatics 7, p. 142.
(2005)
A comparative categorization of gene flux in diverse microbial species.
Genomics 86 (4), pp. 462-475.
Fulltext restricted.
Meinicke, Peter, Tech, Maike, Morgenstern, Burkhard and Merkl, Rainer
(2004)
Oligo kernels for datamining on biological sequences: a case study on prokaryotic translation initiation sites.
BMC Bioinformatics 5 (1), p. 169.
Merkl, Rainer
(2004)
SIGI: score-based identification of genomic islands.
BMC Bioinformatics 5, p. 22.
Brüggemann, Holger, Baumer, Sebastian, Fricke, Wolfgang Florian, Wiezer, Arnim, Liesegang, Heiko, Decker, Ivona, Herzberg, Christina, Martinez-Arias, Rosa, Merkl, Rainer, Henne, Anke and Gottschalk, Gerhard
(2003)
The genome sequence of Clostridium tetani, the causative agent of tetanus disease.
Proceedings of the National Academy of Sciences of the United States of America (PNAS) ISSN 1091-6490.
Larbig, Karen D., Christmann, Andreas, Johann, André, Klockgether, Jens, Hartsch, Thomas, Merkl, Rainer, Wiehlmann, Lotz, Fritz, Hans Joachim and Tümmler, Burkhard
(2002)
Gene Islands Integrated into tRNA(Gly) Genes Confer Genome Diversity on a Pseudomonas aeruginosa Clone.
Journal of Bacteriology 184 (23), pp. 6665-6680.
Merkl, Rainer and Fritz, Hans Joachim
(1996)
Statistical evidence for a biochemical pathway of natural, sequence-targeted G/C to C/G transversion mutagenesis in Haemophilus influenzae Rd.
Nucleic Acids Research 24 (21), pp. 4146-4151.
Merkl, Rainer, Kröger, Manfred, Rice, Peter and Fritz, Hans Joachim
(1992)
Statistical evaluation and biological interpretation of non-random abundance in the E. coli K-12 genome of tetra- and pentanucleotide sequences related to VSP DNA mismatch repair.
Nucleic Acids Research 20 (7), pp. 1657-1662.
Fisher, P. R., Merkl, Rainer and Gerisch, G.
(1989)
Quantitative Analysis of Cell Motility and Chemotaxis in Dictyostelium discoideum by Using an Image Processing System and a Novel Chemotaxis Chamber Providing Stationary Chemical Gradients.
The Journal of Cell Biology (JCB) 108 (3), pp. 973-984.
Francis, D., Toda, K., Merkl, Rainer, Hatfield, T. and Gerisch, G.
(1985)
Mutants of Polysphondylium pallidum altered in cell aggregation and in the expression of a carbohydrate epitope on cell surface glycoproteins.
EMBO Journal 4 (10), pp. 2525-2532.
Noegel, A., Harloff, C., Hirth, P., Merkl, Rainer, Modersitzki, M., Stadler, J., Weinhart, U., Westphal, M. and Gerisch, G.
(1985)
Probing an adhesion mutant of Dictyostelium discoideum with cDNA clones and monoclonal antibodies indicates a specific defect in the contact site A glycoprotein.
EMBO Journal 4 (13B), pp. 3805-3810.
Ochiai, H., Stadler, J., Westphal, M., Wagle, G., Merkl, Rainer and Gerisch, G.
(1982)
Monoclonal antibodies against contact sites A of Dictyostelium discoideum: detection of modifications of the glycoprotein in tunicamycin-treated cells.
EMBO Journal 1 (8), pp. 1011-1016.
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