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Ondansetron-analoge 5-HT3-Rezeptorliganden: Synthese, Stereochemie und in-vitro-Pharmakologie

Jenning, Stefan (2009) Ondansetron-analoge 5-HT3-Rezeptorliganden: Synthese, Stereochemie und in-vitro-Pharmakologie. PhD, Universität Regensburg.

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Date of publication of this fulltext: 19 Jun 2009 15:25

Abstract (German)

In der vorliegenden Arbeit wurden neue Ondansetron-analoge Tetrahydrocarbazolon- und Indol-Derivate synthetisiert und charakterisiert. Deren Wirkung auf den 5-HT3-Rezeptor wurde mittels eines in-vitro pharmakologischen Testmodells am Meerschweinchen-Ileum bestimmt. Durch Austausch des Imidazol-Rings von Ondansetron durch einen Piperidin-Ring wurde ein partieller Agonist erhalten. Durch die ...


Translation of the abstract (English)

In this piece of work some new ondansetron derived tetrahydracarbazolone and indole derivates had been synthesized and characterized. The isolated longitudinal muscle of the guinea-pig with adhering plexus myentericus was used as a 5 HT3 receptor screening assay. Previous results in our group indicated that by replacing the imidazole ring of ondansetron with a piperidin ring a weak partial ...


Export bibliographical data

Item type:Thesis of the University of Regensburg (PhD)
Date:18 June 2009
Referee:Sigurd (Prof. Dr.) Elz
Date of exam:9 May 2008
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry I (Prof. Elz)
Keywords:Trennverfahren , Chemische Synthese , Tetrahydrocarbazole , Indolderivate , Analoga , Pharmakologie , Ligand <Biochemie> , Ondansetron , 5HT3 , Meerschweinchendarm , Enantiomere , Stereochemie , Tetrahydrocarbazolon , 5HT3 , guinea-pig ileum , enantiomers , stereochemistry , tetrahydrocarbazolone
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:12127
Owner only: item control page


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