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Tryptamin-Derivate als 5-HT4-Rezeptorliganden: Synthese und in-vitro-Pharmakologie

Prainer, Bianca-Cristine (2009) Tryptamin-Derivate als 5-HT4-Rezeptorliganden: Synthese und in-vitro-Pharmakologie. PhD, Universität Regensburg.

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Date of publication of this fulltext: 03 Aug 2009 15:25

Abstract (German)

In der vorliegenden Arbeit wurden neue Derivate der Leitstruktur 5-Methoxytryptamin (2-(5-Methoxy-1H-indol-3-yl)ethanamin) hergestellt und mittels in-vitro pharmakologischer Testmodelle auf ihre Wirkung an Serotonin-Rezeptorsubtypen getestet. Die Leitverbindung 5-Methoxytryptamin wurde dabei durch Einführung verschiedener Substituenten in die Position 3 und 5 des Indolrings sowie an den ...


Translation of the abstract (English)

In the present study new derivatives of the lead structure 5-methoxytryptamine have been synthesized and tested for their effect on 5-HT receptors using several pharmacological in-vitro assays. The parent compound 5-methoxytryptamine has been modified by the introduction of several substituents in the 3- and 5-position of the indole ring as well as at the indole nitrogen. The N-alpha-substituted ...


Export bibliographical data

Item type:Thesis of the University of Regensburg (PhD)
Date:2 August 2009
Referee:Sigurd (Prof. Dr.) Elz
Date of exam:21 July 2008
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry I (Prof. Elz)
Keywords:Tryptamin , Serotonin , Ligand <Biochemie> , Tryptaminderivate , Chemische Synthese , Pharmakologie , 5-HT4-Rezeptor , 5-HT2A-Rezeptor , M3-Rezeptor , Rattenösophagus , Rattenschwanzarterie , 5-HT4-receptor , 5-HT2A-receptor , M3-receptor , rat oesophagus , rat tail artery
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:12132
Owner only: item control page


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