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Tryptamin-Derivate als 5-HT4-Rezeptorliganden: Synthese und in-vitro-Pharmakologie

URN to cite this document:
urn:nbn:de:bvb:355-opus-10454
Prainer, Bianca-Cristine
Date of publication of this fulltext: 03 Aug 2009 15:25


Abstract (German)

In der vorliegenden Arbeit wurden neue Derivate der Leitstruktur 5-Methoxytryptamin (2-(5-Methoxy-1H-indol-3-yl)ethanamin) hergestellt und mittels in-vitro pharmakologischer Testmodelle auf ihre Wirkung an Serotonin-Rezeptorsubtypen getestet. Die Leitverbindung 5-Methoxytryptamin wurde dabei durch Einführung verschiedener Substituenten in die Position 3 und 5 des Indolrings sowie an den ...

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Translation of the abstract (English)

In the present study new derivatives of the lead structure 5-methoxytryptamine have been synthesized and tested for their effect on 5-HT receptors using several pharmacological in-vitro assays. The parent compound 5-methoxytryptamine has been modified by the introduction of several substituents in the 3- and 5-position of the indole ring as well as at the indole nitrogen. The N-alpha-substituted ...

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