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Functional analysis of the mouse histamine H4 receptor in myeloid cells

Jouma, Louay (2009) Functional analysis of the mouse histamine H4 receptor in myeloid cells. PhD, Universität Regensburg.

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Date of publication of this fulltext: 18 Jan 2010 14:11

Abstract (English)

Several reports have identified the H4R as an important receptor in inflammatory mechanisms and thus, as a therapeutic target for several diseases. The focus of this work was to identify and further characterize the role of mH4R on mouse myeloid immune cells. A novel finding of this thesis is the expression of mH4R in DC macrophages, and T cells (CD4+, CD8+) which was determined on the mRNA ...


Translation of the abstract (German)

Der H4R wurde in mehreren Berichten als Rezeptor, der eine wichtige Rolle bei entzündlichen Mechanismen spielt, beschrieben. Aus diesem Grund stellt er einen therapeutischen Angriffspunkt für verschiedene Krankheiten dar. Der Fokus dieser Arbeit war die Identifizierung und weitere Charakterisierung der Rolle des H4R auf myeloiden Immunzellen in der Maus. In dieser Doktorarbeit konnte erstmals die ...


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Item type:Thesis of the University of Regensburg (PhD)
Date:15 October 2009
Referee:Daniela N. (Prof. Dr.) Männel
Date of exam:2 October 2009
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann, formerly Prof. Seifert)
Keywords:H4R , Histamin , Makrophage , Maus , Histaminrezeptor , , histamine H4 receptor , histamine , macrophages
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:12349
Owner only: item control page


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