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Number of items at this level: 228.

2019

Schramm, Andrea, Schweda, Frank, Sequeira-Lopez, Maria Luisa S., Hofmann, Franz, Sandner, Peter and Schlossmann, Jens (2019) Protein Kinase G Is Involved in Acute but Not in Long-Term Regulation of Renin Secretion. Frontiers in Pharmacology 2019 (10), p. 800.

2018

Walz, Johanna Madeleine (2018) VEGF-Inhibition bei der Frühgeborenenretinopathie
- Präklinische und klinische Aspekte -.
PhD, Universität Regensburg.

Schramm, Andrea, Mueller-Thuemen, Philip, Littmann, Timo, Harloff, Manuela, Ozawa, Takeaki and Schlossmann, Jens (2018) Establishing a Split Luciferase Assay for Proteinkinase G (PKG) Interaction Studies. International Journal o f Molecular Sciences 19 (4), p. 1180.

Paolillo, Michael , Peters, Stefanie, Schramm, Andrea, Schlossmann, Jens and Feil, Robert (2018) Real-Time Imaging Reveals Augmentation of Glutamate-Induced Ca2+ Transients by the NO-cGMP Pathway in Cerebellar Granule Neurons. International Journal of Molecular Sciences 19, p. 2185.

2017

Wetzl, Veronika (2017) Fibrose-assoziierte Biomarker – Einfluss der Behandlung mit Serelaxin im murinen Nierenfibrose-Modell und prädiktiver Aussagewert in der pulmonalen Hypertonie. PhD, Universität Regensburg.

Scheck, Luisa (2017) Characterization of TSPO 18 kDa in neurosteroid synthesis and mitochondrial metabolism. Dissertationsreihe der Fakultät für Chemie und Pharmazie der Universität Regensburg PhD, Universität Regensburg.

Liebchen, Uwe (2017) Proteinbindungscharakter und Pharmakokinetik von Ertapenem bei Intensivpatienten. PhD, Universität Regensburg.

Schlossmann, Jens, Schinner, Elisabeth, Wetzl, Veronika, Schramm, Andrea, Kees, Frieder, Sandner, Peter, Stasch, Johannes-Peter and Hofmann, Franz (2017) Inhibition of the TGFβ signalling pathway by cGMP and cGMP‐dependent kinase I in renal fibrosis. FEBS openbio 7 (4), pp. 550-561.

Unholzer, S., Rothmund, A. and Haen, E. (2017) Alleskönner Vitamin D? Der Nervenarzt 88 (5), pp. 489-494. Fulltext not available.

Boehr, Sebastian and Haen, Ekkehard (2017) Development of an UHPLC-UV-Method for Quantification of Direct Oral Anticoagulants. Therapeutic Drug Monitoring 39 (1), pp. 66-76. Fulltext not available.

Wetzl, Veronika, Schinner, Elisabeth, Kees, Frieder, Faerber, Lothar and Schlossmann, Jens (2017) Differences in the renal antifibrotic cGMP/cGKI-dependent signaling of serelaxin, zaprinast, and their combination. Naunyn-Schmiedeberg's Archives of Pharmacology 390 (9), pp. 939-948. Fulltext not available.

Ittner, Karl, Koppenberg, Joachim and Walter, Ute (2017) Indikationsfremde Anwendung von Medikamenten und Medizinprodukten in der Notfallmedizin. Der Notarzt 33 (04), pp. 178-188. Fulltext not available.

Paulzen, Michael, Schoretsanitis, Georgios , Stegmann, Benedikt, Hiemke, Christoph, Gründer, Gerhard, Schruers, Koen R.J., Walther, Sebastian , Lammertz, Sarah E. and Haen, Ekkehard (2017) Pharmacokinetic considerations in antipsychotic augmentation strategies: How to combine risperidone with low-potency antipsychotics. Progress in Neuro-Psychopharmacology and Biological Psychiatry 76, pp. 101-106. Fulltext not available.

Wetzl, Veronika, Tiede, Svenja Lena, Faerber, Lothar, Weissmann, Norbert , Schermuly, Ralph Theo , Ghofrani, Hossein Ardeschir and Gall, Henning (2017) Plasma MMP2/TIMP4 Ratio at Follow-up Assessment Predicts Disease Progression of Idiopathic Pulmonary Arterial Hypertension. Lung 195 (4), pp. 489-496. Fulltext not available.

2016

Onuoha, Mary Remigius Agatha (2016) Therapeutic Drug Monitoring of Antipsychotics - HPLC Analytical Method Development and Pharmaceutical Advices to the Ward Clinicians - For Successful Individualized Therapy. PhD, Universität Regensburg.

Schlossmann, Jens, Wetzl, Veronika, Schinner, Elisabeth, Kees, Frieder K., Hofmann, Franz and Faerber, Lothar (2016) Involvement of cyclic guanosine monophosphate-dependent protein kinase I in renal antifibrotic effects of serelaxin. Frontiers in Pharmacology 7 (195), pp. 1-27.

Kratzer, Alexander Ludwig (2016) Entwicklung und Erprobung von HPLC-basierten Methoden für das Therapeutische Drug-Monitoring von Betalaktam-Antibiotika, Linezolid und Tigecyclin – Bestimmung von freien und totalen Konzentrationen im Plasma von Intensivpatienten. PhD, Universität Regensburg.

Limmer, Franziska (2016) Funktionelle Analyse der cGMP-abhängigen Proteinkinase I in der Niere, insbesondere im dicken aufsteigenden Ast der Henle-Schleife. PhD, Universität Regensburg.

Stangl, Hubert Werner (2016) Arthritis and cholinergic transition of sympathetic nerve fibers. PhD, Universität Regensburg.

Vögeler, Jessica (2016) Pharmakotherapie und Humanpharmakologische Untersuchungen bei Patienten mit DME (Diabetisches Makulaödem) und PDR (Proliferative Diabetische Retinopathie) anhand klinischer Parameter und inflammatorischer Biomarker. PhD, Universität Regensburg.

Paulzen, M., Haen, Ekkehard and Stegmann, Benedikt (2016) Pharmacokinetic considerations in the treatment of hypertension in risperidone-medicated patients – thinking of clinically relevant CYP2D6 interactions. Journal of Psychopharmacology 30, pp. 903-809.

2015

Wolfertstetter, Stefanie (2015) Funktion von cCMP und cCMP-spezifischen Signalwegen. PhD, Universität Regensburg.

Wolferstetter, Stefanie, Reinders, Jörg, Schwede, Frank, Ruth, Peter, Schinner, Elisabeth and Schlossmann, Jens (2015) Interaction of cCMP with the cGK, cAK and MAPK Kinases in Murine Tissues. PLoS ONE 10 (5), e0126057.

Jenei-Lanzl, Zsuzsa, Capellino, Silvia, Kees, Frieder , Fleck, Martin, Lowin, Torsten and Straub, Rainer H. (2015) Anti-inflammatory effects of cell-based therapy with tyrosine hydroxylase-positive catecholaminergic cells in experimental arthritis. Annals of the Rheumatic Diseases 74, pp. 444-451.

Huber, Stefan, Huettner, Johannes Philip, Kristina, Hacker, Bernhardt, Günther, König, Jörg and Buschauer, Armin (2015) Esters of bendamustine are by far more potent cytotoxic agents than the parent compound against human sarcoma and carcinoma cells. PLoS One 10 (7), PLoSe0133743.

Strasser, Andrea, Wittmann, Hans-Joachim, Schneider, Erich H. and Seifert, Roland (2015) Modulation of GPCRs by monovalent cations and anions. Naunyn-Schmiedeberg's Archives of Pharmacology 388, pp. 363-380. Fulltext not available.

2014

Haunschild, Gundula (2014) Nachweis und molekulare Charakterisierung EpCAM-positiver Zellen im Knochenmark von Mammakarzinom-Patientinnen. PhD, Universität Regensburg.

Schramm, Andrea (2014) Analyse renaler Funktionen der cGMP-abhängigen Proteinkinase II. PhD, Universität Regensburg.

2013

Kees, Martin Georg, Schaeftlein, André, Haeberle, Helene Anna, Kees, Frieder K., Kloft, Charlotte and Heininger, Alexandra (2013) Population pharmacokinetics and pharmacodynamic evaluation of intravenous and enteral moxifloxacin in surgical intensive care unit patients. The Journal of antimicrobial chemotherapy. Fulltext not available.

Chen, W., Oberwinkler, H., Werner, F., Gaßner, B., Nakagawa, H,, Feil, R., Hofmann, F., Schlossmann, Jens, Dietrich, A., Gudermann, T., Nishida, M., Del Galdo, S., Wieland, T. and Kuhn, M. (2013) ANP-mediated inhibition of microcirculatory endothelial Ca 2+ and permeability response to histamine involves cGMP-dependent protein kinase I and TRPC6 channels. Arteriosclerosis, Thrombosis, and Vascular Biology 33 (9), pp. 2121-2129. (In Press) Fulltext not available.

Dietrich, P., Moleda, Lukas, Kees, Frieder K., Müller, M., Straub, R. H., Hellerbrand, C. and Wiest, R. (2013) Dysbalance in sympathetic neurotransmitter release and action in cirrhotic rats: impact of exogenous neuropeptide Y. Journal of hepatology 58 (2), pp. 254-261. Fulltext not available.

Schlossmann, Jens (2013) Editorial of the Special issue: signalling molecules and Signal transduction in cells. Int. J. Mol. Sci. 14, 1-x, doi:103390/ijms140x000x 14 (6), pp. 11438-11443. Fulltext not available.

Salb, Katharina and Schlossmann, Jens (2013) Methods for identification of cGKI substrates. In: UNSPECIFIED Methods in Molecular Biology, 1020. Methods in Molecular Biology, pp. 147-162. Fulltext not available.

Schinner, E., Schramm, A., Kees, F., Hofmann, F. and Schlossmann, Jens (2013) Suppression of kidney fibrosis by cGMP-dependent protein Kinase Ia. Kidney International. (In Press) Fulltext not available.

Wolfertstetter, Stefanie, Huettner, Johannes Philip and Schlossmann, Jens (2013) cGMP-dependent Protein Kinase Inhibitors in Health and Disease. Pharmaceuticals 6, pp. 269-286.

2012

Hieke, Bernhard (2012) Bedeutung von IRAG für die Calciumregulation im glatten Muskel. PhD, Universität Regensburg.

Salb, Katharina (2012) Funktion von IRAG für cGMP-Kinase-I-Komplexe sowie für die InsP3R-I-Phosphorylierung. PhD, Universität Regensburg.

Peter, Katrin (2012) Einfluss der Tumormetaboliten 5'-Deoxy-5'-Methylthioadenosin und Milchsäure auf humane Monozyten. PhD, Universität Regensburg.

Deml, Karl-Friedrich (2012) Interaktionen von Histamin H1-Rezeptoragonisten und
–antagonisten mit dem humanen Histamin H4-Rezeptor.
PhD, Universität Regensburg.

Schlossmann, Jens and Schinner, E. (2012) cGMP becomes a drug target. Naunyn Schmiedeberg´s Archives of Pharmacology 385 (3), pp. 243-252.

Doser, Kristina (2012) Untersuchungen zur B-Zell-Rekonstitution nach allogener Stammzelltransplantation. PhD, Universität Regensburg.

Rupprecht, Korbinian (2012) Einfluss von Pantoprazol auf die Bioverfügbarkeit von Mycophenolsäure aus CellCept® bzw. myfortic®: Pharmakokinetische Untersuchungen in vitro und an Probanden. PhD, Universität Regensburg.

Salb, Katharina, Schinner, Elisabeth and Schlossmann, Jens (2012) Identification of cGMP-Kinase complexes by affinity chromatography. In: INTECH Chapter in Affinity Chromatography. , pp. 255-272. ISBN 978-953-51-0325-7. Fulltext not available.

Taha, Hesham, Dove, Stefan, Geduhn, Jens, König, Burkhard, Shen, Yuequan, Tang, Wei-Jen and Seifert, Roland (2012) Inhibition of the adenylyl cyclase toxin, edema factor, from Bacillus anthracis by a series of 18 monoand bis-(M)ANT-substituted nucleoside 5′-triphosphates. Naunyn-Schmiedeberg's Archives of Pharmacology (385), pp. 57-68. Fulltext not available.

Kees, Martin G., Steinke, T., Moritz, S., Rupprecht, K., Paulus, E. M., Kees, Frieder K., Bucher, M. and Faerber, L. (2012) Omeprazole impairs the absorption of mycophenolate mofetil but not of enteric-coated mycophenolate sodium in healthy volunteers. Journal of clinical pharmacology 52 (8), pp. 1265-1272. Fulltext not available.

Justinger, Christoph, Schilling, Martin K., Kees, Martin G., Kauffels, Anne, Hirschmann, Katrin, Kopp, Berit, Kees, Frieder K. and Kollmar, Otto (2012) Penetration of moxifloxacin into liver tissue. International journal of antimicrobial agents 39 (6), pp. 505-509. Fulltext not available.

Luo, C., Gangadharan, V., Bali, K.K., Xie, R.G., Agarwal, N., Kurejova, M., Tappe-Theodor, A., Tegeder, I., Feil, S., Lewin, G., Polgar, E., Todd, A.J., Schlossmann, Jens, Hofmann, F., Liu, D.L., Hu, S.J., Feil, R., Kuner, T. and Kuner, R. (2012) Presynaptically localized cyclic GMP-dependent Protein Kinase I is a key determinant of spinal potentiation and pain hypersensitivity. PLoS Biology 10 (3), 1e1001283.

Jaumann, M., Dettling, J., Gubelt, M., Zimmermann, U., Gerling, A., Paquet-Durand, F., Feil, S., Wolpert, S., Franz, C., Varakina, K., Xiong, H., Brandt, N., Kuhn, S., Geisler, H.-S., Rohbock, K., Ruth, P., Schlossmann, Jens, Hütter, J., Sandner, P., Feil, R., Engel, J., Knipper, M. and Rüttiger, L. (2012) cGMP-Prkg1 signaling and Pde5 inhibition shelter cochlear hair cells and heraring function. Nature Medicine 18, pp. 252-259. Fulltext not available.

2011

Hübner, Melanie, Dixit, A., Mou, T.-C., Lushington, Gerald H., Pinto, Cibele S., Gille, A., Geduhn, Jens, König, Burkhard, Sprang, S. R. and Seifert, Roland (2011) Structural Basis for the High-Affinity Inhibition of Mammalian Membranous Adenylyl Cyclase by 2`,3`-O-(N-Methylanthraniloyl)-Inosine 5`-Triphosphate. Molecular Pharmacology 80 (1), pp. 87-96. Fulltext not available.

Schinner, Elisabeth (2011) Funktionelle Studie der NO/cGMP Signalkaskade in Niere und Thrombozyten. PhD, Universität Regensburg.

Erdorf, Miriam and Seifert, Roland (2011) Pharmacological characterization of adenylyl cyclase isoforms in rabbit kidney membranes. Naunyn-Schmiedeberg's Archives of Pharmacology 383 (4), pp. 357-372. Fulltext not available.

Kellermann, K., Dertinger, N., Blobner, M., Kees, Frieder, Kochs, E. F. and Jungwirt, B. (2011) Perioperative moxifloxacin treatment in rats subjected to deep hypothermic circulatory arrest: reduction in cerebral inflammation but without improvement in cognitive performance. Journal of Thoracic and Cardiovascular Surgery 141 (3), pp. 796-802. Fulltext not available.

Schnell, David, Brunskole, Irena, Ladova, Katerina, Schneider, Erich H., Igel, Patrick, Dove, Stefan, Buschauer, Armin and Seifert, Roland (2011) Expression and functional properties of canine, rat and murine histamine H4-receptors in Sf9 insect cells. Naunyn-Schmiedeberg's Archives of Pharmacology 383 (5), pp. 457-470. Fulltext not available.

Geduhn, Jens, Dove, Stefan, Shen, Yuequan, Tang, Wei-Jen, König, Burkhard and Seifert, Roland (2011) Bis-Halogen-Anthraniloyl-Substituted Nucleoside 5'-triphosphates as Potent and Selective Inhibitors of Bordetella pertussis CyaA. The Journal of pharmacology and experimental therapeutics 336 (1), pp. 104-115. Fulltext not available.

Schinner, Elisabeth, Salb, Katharina and Schlossmann, Jens (2011) Signaling via IRAG is essential for NO/cGMP-dependent inhibition of platelet activitation. Platelets. Fulltext not available.

Salb, Katharina, Schinner, Elisabeth and Schlossmann, Jens (2011) Function of IRAG and the phosphorylation of the InsP3R-I for the NO/cGMP-dependent inhibition of platelet aggregation. BMC Pharmacology (11), P58.

Schlossmann, Jens and Desch, M. (2011) IRAG and Novel PKG Targeting in the cardiovascular system. American Journal of Physiology- Heart und Circulatory Physiology 301, H672-682. Fulltext not available.

Ertl, C., Lukowski, R., Sigl, K, Schlossmann, Jens, Hofmann, F. and Wegener, Jörg W. (2011) Kinetics of relaxation by cGMP/cGKI signaling in fundus smooth muscle. Eur J Pharmacol 670 (1), pp. 266-271. Fulltext not available.

Kees, Martin G., Weber, Susanne, Kees, Frieder K. and Horbach, Thomas (2011) Pharmacokinetics of moxifloxacin in plasma and tissue of morbidly obese patients. The Journal of antimicrobial chemotherapy 66 (10), pp. 2330-2335. Fulltext not available.

Pinto, Cibele S., Lushington, Gerald H., Richter, M., Gille, A., Geduhn, Jens, König, Burkhard, Mou, T.-C., Sprang, S. R. and Seifert, Roland (2011) Structure–activity relationships for the interactions of 2`- and 3`-(O)-(N-methyl)anthraniloyl-substituted purine and pyrimidine nucleotides with mammalian adenylyl cyclases. Biochemical Pharmacology 82 (4), pp. 358-370. Fulltext not available.

Werder, A., Mayr, M., Schneider, G., Oesterle, D., Fritsch, R. M., Seidler, B., Schlossmann, Jens, Hofmann, F., Schemann, M., Allescher, H. D., Schmid, R.M. and Saur, D. (2011) Truncated IRAG variants modulate cGMP-mediated inhibition of human colonic smooth muscle cell contraction. American Journal of Physiology - Cell Physiology : Am J Physiol Cell Physiol 301 (6), C1445-1457. Fulltext not available.

2010

Kees, MG, Hilpert, JW, Gnewuch, C, Kees, F. and Voegeler, S. (2010) Clearance of vancomycin during continuous infusion in intensive care unit patients: correlation with measured and estimated creatinine clearance and serum cystatin C. International Journal of Antimicrobial Agents 36 (6), pp. 545-548. Fulltext not available.

Appl, Heidrun (2010) Molecular analysis of the interaction of the four histamine receptor subtypes with antidepressant and antipsychotic drugs. PhD, Universität Regensburg.

Schnell, David, Strasser, Andrea and Seifert, Roland (2010) Comparison of the pharmacological properties of human and rat histamine H(3)-receptors. Biochemical Pharmacology 80 (9), pp. 1437-1449. Fulltext not available.

Erdorf, Miriam (2010) Regulation of mammalian membranous adenylyl cyclases by diterpenes and MANT-nucleotides. PhD, Universität Regensburg.

Desch, Matthias (2010) Funktionelle Charakterisierung des cGMP-abhängigen Proteinkinase-Substrates IRAG und des potentiellen "second messenger" zyklisches Cytidin-3',5'-monophosphat im glatten Muskel. PhD, Universität Regensburg.

Hübner, Melanie (2010) Crystal structure of the catalytic domains of membranous adenylyl cyclase with MANT-ITP and electrophysiological analysis of MANT nucleotides in cardiomyocytes. PhD, Universität Regensburg.

Mathar, I., Vennekens, R., Meissner, M., Kees, Frieder K., Van der Mieren, G. and Camacho Londono, J. (2010) Increased catecholamine secretion contributes to hypertension in TRPM4-deficient mice. The Journal of Clinical Investigation 120 (9), pp. 3267-3279. Fulltext not available.

Desch, Matthias, Schinner, Elisabeth, Kees, Frieder K., Hofmann, F., Seifert, Roland and Schlossmann, Jens (2010) Cyclic cytidine 3´,5´-monophosphate (cCMP) signals via cGMP kinase I. FEBS Letters 584 (18), pp. 3979-3984. Fulltext not available.

Schneider, E. H., Strasser, Andrea, Thurmond, R. L. and Seifert, Roland (2010) Structural requirements for inverse agonism and neutral antagonism of indole-, benzimidazole-, and thienopyrrole-derived histamine H4 receptor ligands. Journal of Pharmacology and Experimental Therapeutics 334 (2), pp. 513-521. Fulltext not available.

Spangler, Corinna (2010) Molecular and cellular analysis of the "adenylyl cyclase" exotoxins from Bacillus anthracis and Bordetella pertussis. PhD, Universität Regensburg.

Desch, Matthias, Sigl, K., Hieke, Bernhard, Salb, Katharina, Kees, F. and Bernhard, D. (2010) IRAG determines nitric oxide- and atrial natriuretic peptide-mediated smooth muscle relaxation. Cardiovascular Research 86 (3), pp. 496-505. Fulltext not available.

Weitl, Nina (2010) Interaktionen des humanen β1- und β2- Adrenorezeptors mit Isoproterenol, Epinephrin, Norepinephrin und Dopamin. PhD, Universität Regensburg.

Schnell, David and Seifert, Roland (2010) Modulation of Histamine H(3) receptor function by monovalent ions. Neuroscience Letters 472 (2), pp. 114-118. Fulltext not available.

Schnell, David, Burleigh, Katrina, Seifert, Roland and Trick, Jonathan (2010) No evidence for functional selectivity of proxyfan at the human histamine H3 receptor coupled to defined Gi/Go protein heterotrimers. Journal of Pharmacology and Experimental Therapeutics . JPET 332 (3), pp. 996-1005. Fulltext not available.

Schnell, David (2010) Molecular analysis of the histamine H3-receptor. PhD, Universität Regensburg.

Schilling, Elmar (2010) Analysis of tissue-specific & allele-specific DNA methylation. PhD, Universität Regensburg.

Mohammed, Hesham Hamada Taha (2010) Molecular analysis of adenylyl cyclase: Bacillus anthracis edema factor exotoxin. PhD, Universität Regensburg.

Göttle, Martin, Dove, Stefan, Kees, Frieder K., Schlossmann, Jens, Geduhn, Jens, König, Burkhard, Shen, Y., Tang, W. J., Kaever, V. and Seifert, Roland (2010) Citidylyl and uridylyl cyclase activity of bacillus anthracis edema factor and Bordetella pertussis CyaA. Biochemistry 49, pp. 5494-5503. Fulltext not available.

Desch, M., Sigl, K., Hieke, B., Salb, Katharina, Kees, Frieder, Bernhard, D., Jochim, A., Spiessberger, B., Höcherl, K., Feil, R., Lukowski, R., Wegener, Jörg W., Hofmann, F. and Schlossmann, Jens (2010) IRAG determines NO- and ANP-mediated smooth muscle relaxation. Cardiovascular Research 86 (3), pp. 496-505. Fulltext not available.

Schneider, Erich H., Schnell, David, Strasser, Andrea, Dove, Stefan and Seifert, Roland (2010) Impact of the DRY Motif and the Missing "Ionic Lock" on Constitutive Activity and G-Protein Coupling of the Human Histamine H-4 Receptor. Journal of Pharmacology and Experimental Therapeutics 333 (2), pp. 382-392. Fulltext not available.

Schneider, Erich, Schnell, David, Strasser, Andrea, Dove, Stefan and Seifert, Roland (2010) Impact of the DRY motif and the missing "ionic lock" on constitutive activity and G-protein coupling of the human histamine H4 receptor. J Pharmacol Exp Ther : The journal of pharmacology and experimental therapeutics 333 (2), pp. 382-392. Fulltext not available.

2009

Jouma, Louay (2009) Functional analysis of the mouse histamine H4 receptor in myeloid cells. PhD, Universität Regensburg.

Igel, Patrick, Geyer, Roland, Straßer, Andrea, Dove, Stefan, Seifert, Roland and Buschauer, Armin (2009) Synthesis and structure-activity relationships of cyanoguanidine-type and structurally related histamine H(4) receptor agonists. Journal of Medicinal Chemistry 52 (20), pp. 6297-6313. Fulltext not available.

Ratzinger, Sabine (2009) Studies on the molecular interactions of collagen type XVI.
Part I: The role of collagen XVI in pathological disorders
Part II: Extablishment of a retroviral mediated gene silencing model.
PhD, Universität Regensburg.

Göttle, Martin (2009) Molecular analysis of mammalian adenylyl cyclases and bacterial adenylyl cyclase toxins. PhD, Universität Regensburg.

Igel, Patrick, Schneider, Erich, Schnell, David, Elz, Sigurd, Seifert, Roland and Buschauer, Armin (2009) N(G)-Acylated imidazolylpropylguanidines as potent histamine H4 receptor agonists: selectivity by variation of the N(G)-substituent. Journal of Medicinal Chemistry 52 (8), pp. 2623-2627. Fulltext not available.

Kraus, Anja, Ghorai, Prasanta, Birnkammer, Tobias, Schnell, David, Elz, Sigurd, Seifert, Roland, Dove, Stefan, Bernhardt, Günther and Buschauer, Armin (2009) N(G)-Acylated aminothiazolylpropylguanidines as potent and selective histamine H2 receptor agonists. ChemMedChem 4 (2), pp. 232-240. Fulltext not available.

Igel, Patrick, Schnell, David, Bernhardt, Günther, Seifert, Roland and Buschauer, Armin (2009) Tritium-labeled N1-[3-(1H-imidazol-4-yl)propyl]-N2-propionylguanidine ([3H]UR-PI294), a high affinity histamine H3 and H4 receptor radioligand. ChemMedChem 4 (2), pp. 225-231. Fulltext not available.

Frei, E., Huster, M., Smital, P., Schlossmann, Jens, Hofmann, F. and Wegener, Jörg W. (2009) Calcium-dependent and Calcium-independent inhibition of contraction by cGMP/cGKI in intestinal smooth muscle. American Journal of Physiology 297, G834-839. Fulltext not available.

Seifert, Roland and Dove, Stefan (2009) Functional Selectivity of GPCR Ligand Stereoisomers: New Pharmacological Opportunities. Mol. Pharmacol. 75 (1), pp. 13-18. Fulltext not available.

Deml, Karl-Friedrich, Beermann, S, Neumann, Detlef, Strasser, Andrea and Seifert, Roland (2009) Interactions of histamine H1-receptor agonists and antagonists with the human histamine H4-receptor. Mol Pharmacol : Molecular pharmacology 76 (5), pp. 1019-1030. Fulltext not available.

Taha, H. M., Schmidt, J., Göttle, M., Suryanarayana, S., Shen, Y., Tang, W.-J., Gille, A., Geduhn, Jens, König, Burkhard, Dove, Stefan and Seifert, Roland (2009) Molecular Analysis of the Interaction of Anthrax Adenylyl Cyclase Toxin, Edema Factor, with 2'(3')-O-(N-(methyl)anthraniloyl)-Substituted Purine and Pyrimidine Nucleotides. Mol. Pharmacol. 75 (3), pp. 693-703. Fulltext not available.

Egger, Michael, Maity, Prantik, Hübner, Melanie, Seifert, Roland and König, Burkhard (2009) Synthesis and pharmacological properties of new tetracyclic forskolin analogues. European Journal of Organic Chemistry 2009 (21), pp. 3613-3618. Fulltext not available.

Schlossmann, Jens and Desch, M. (2009) cGK substrates. Handbook of Experimental Pharmacology 191, pp. 163-193. Fulltext not available.

2008

Ghorai, Prasanta, Kraus, Anja, Keller, Max, Götte, Carsten, Igel, Patrick, Schneider, Erich, Schnell, David, Bernhardt, Günther, Dove, Stefan, Zabel, Manfred, Elz, Sigurd, Seifert, Roland and Buschauer, Armin (2008) Acylguanidines as bioisosteres of guanidines: N(G)-acylated imidazolylpropylguanidines, a new class of histamine H2 receptor agonists. Journal of Medicinal Chemistry 51 (22), pp. 7193-7204. Fulltext not available.

Dove, Stefan, Seifert, Roland, Elz, Sigurd and Buschauer, Armin (2008) Frontiers in medicinal chemistry in Regensburg. ChemMedChem 3 (8), pp. 1181-1184. Fulltext not available.

Schlossmann, Jens and Hofmann, F. (2008) Receptor mediated mechanisms. In: Greim, H. and Snyder, R., (eds.) Toxicology and risk assessment : a comprehensive introduction. Wiley, Chicester. ISBN 978-0-470-86893-5. Fulltext not available.

Schmidtko, A., Gao, W., König, P., Heine, S., Motterlini, R., Ruth, P., Schlossmann, Jens, Koesling, D., Niederberger, E., Tegeder, I., Friebe, A. and Geisslinger, G. (2008) cGMP produced by NO-sensitive guanylyl cyclase essentially contributes to inflammatory and neuropathic pain by using targets different from cGMP-dependent protein kinase I. Journal of Neuroscience 28, pp. 8568-8576. Fulltext not available.

2007

Göttle, Martin, Dove, Stefan, Steindel, Phillip, Shen, Yuequan, Tang, Wei-Jen, Geduhn, Jens, König, Burkhard and Seifert, Roland (2007) Molecular Analysis of the Interaction of Bordetella pertussis Adenylyl Cyclase with Fluorescent Nucleotides. Molecular Pharmacology 72 (3), pp. 526-535.

Lorenz, Veronika, Pinto, Cibele S. and Seifert, Roland (2007) Complex changes in ecto-nucleoside 5'-triphosphate diphosphohydrolase expression in hypoxanthine phosphoribosyl transferase deficiency. Neuroscience Letters 420 (1), pp. 6-11.

Wang, Jenna L., Guo, Jian-Xin, Zhang, Qi-Yuan, Wu, Jay J.-Q., Seifert, Roland and Lushington, Gerald H. (2007) A conformational transition in the adenylyl cyclase catalytic site yields different binding modes for ribosyl-modified
and unmodified nucleotide inhibitors.
Bioorganic & Medicinal Chemistry 15 (8), pp. 2993-3002.

Preuss, Hendrik, Ghorai, Prasanta, Kraus, Anja, Dove, Stefan, Buschauer, Armin and Seifert, Roland (2007) Constitutive Activity and Ligand Selectivity of Human,
Guinea Pig, Rat, and Canine Histamine H₂ Receptors.
Journal of Pharmacology and Experimental Therapeutics 321 (3), pp. 983-995.

Preuss, Hendrik, Ghorai, Prasanta, Kraus, Anja, Dove, Stefan, Buschauer, Armin and Seifert, Roland (2007) Mutations of Cys-17 and Ala-271 in the Human Histamine H₂
Receptor Determine the Species Selectivity of Guanidine-Type Agonists and Increase Constitutive Activity.
Journal of Pharmacology and Experimental Therapeutics 321 (3), pp. 975-982.

Xie, Sheng-Xue, Schalkhausser, Fabian, Ye, Qi-Zhuang, Seifert, Roland and Buschauer, Armin (2007) Effects of Impromidine- and Arpromidine-Derived Guanidines on Recombinant Human and Guinea Pig Histamine H₁ and H₂ Receptors. Archiv der Pharmazie 340 (1), pp. 9-16.

Rottlaender, Dennis, Matthes, Jan, Vatner, Stephen F., Seifert, Roland and Herzig, Stefan (2007) Functional Adenylyl Cyclase Inhibition in Murine
Cardiomyocytes by 2'(3')-O-(N-Methylanthraniloyl)-Guanosine
5'-[γ-Thio]triphosphate.
Journal of Pharmacology and Experimental Therapeutics 321 (2), pp. 608-615.

Antl, M., von Brühl, M. L., Eigslperger, C., Werner, M., Konrad, I., Köcher, T., Wilm, M., Hofmann, F., Massberg, S. and Schlossmann, Jens (2007) IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation. Blood 109, pp. 552-559. Fulltext not available.

Kees, F., Bucher, M., Schweda, F., Gschaidmeier, H., Faerber, L. and Seifert, R. (2007) Neoimmun versus Neoral: a bioequivalence study in healthy volunteers and influence of a fat-rich meal on the bioavailability of Neoimmun. Naunyn-Schmiedeberg's Archives of Pharmacology 375 (6), pp. 393-399.

Preuss, Hendrik, Ghorai, Prasanta, Kraus, Anja, Dove, Stefan, Buschauer, Armin and Seifert, Roland (2007) Point Mutations in the Second Extracellular Loop of the Histamine H2 Receptor do not affect the Species-Selective Activity of Guanidine-Type Agonists. Naunyn Schmiedebergs Arch. Pharmacol. 376 (4), pp. 253-264. Fulltext restricted.

Sausbier, M., Zhou, X.B., Beier, C., Sausbier, U., Wolpers, D., Maget, S., Martin, C., Dietrich, A., Ressmeyer, A.R., Schlossmann, Jens, Hofmann, F., Neuhuber, W., Gudermann, T., Uhlig, S., Korth, M. and Ruth, P. (2007) Reduced rather than enhanced cholinergic airway constriction in mice with ablation of the large conductance Ca2+-activated K+channel. FASEB Journal 21, pp. 812-822. Fulltext not available.

Weber, S., Bernhard, D., Lukowski, R., Weinmeister, P., Wörner, R., Wegener, J. W., Valtcheva, N., Feils, S., Schlossmann, Jens, Hofmann, F. and Feil, R. (2007) Rescue of cGMP Kinase I knockout mice by smooth muscle specific expression of either isozyme. Circulation Research 101, pp. 1096-1103. Fulltext not available.

2006

Kees, Frieder, Bucher, Michael, Schweda, Frank, Gschaidmeier, Harald, Burhenne, Juergen, Mikus, Gerd and Faerber, Lothar (2006) Comparative bioavailability of the microemulsion formulation of cyclosporine (Neoral) with a generic dispersion formulation (Cicloral) in young healthy male volunteers. Therapeutic drug monitoring 28 (3), pp. 312-320. Fulltext restricted.

Xie, Sheng-Xue, Kraus, Anja, Ghorai, Prasanta, Ye, Qi-Zhuang, Elz, Sigurd, Buschauer, Armin and Seifert, Roland (2006) N1-(3-Cyclohexylbutanoyl)-N2-[3-(1H-imidazol-4-
yl)propyl]guanidine (UR-AK57), a Potent Partial Agonist for the Human Histamine H1- and H2- Receptors.
Journal of Pharmacology and Experimental Therapeutics 317 (3), pp. 1262-1268. Fulltext restricted.

Xie, Sheng-Xue, Ghorai, Prasanta, Ye, Qi-Zhuang, Buschauer, Armin and Seifert, Roland (2006) Probing Ligand-Specific Histamine H1- and H2-Receptor
Conformations with NG-Acylated Imidazolylpropylguanidines.
The Journal of Pharmacology and Experimental Therapeutics 317 (1), pp. 139-146. Fulltext restricted.

Pinto, Cibele S. and Seifert, Roland (2006) Decreased GTP-stimulated adenylyl cyclase activity in
HPRT-deficient human and mouse fibroblast and rat
B103 neuroblastoma cell membranes.
Journal of Neurochemistry 96 (2), pp. 454-459. Fulltext restricted.

Hofmann, F., Feil, R., Kleppisch, T. and Schlossmann, Jens (2006) Function of cGMP-dependent Protein Kinase as revealed by gene deletion. Physiological Reviews 86, pp. 1-23. Fulltext not available.

2005

Feil, S., Zimmermann, P., Knorn, A., Brummer, S., Schlossmann, Jens, Hofmann, F. and Feil, R. (2005) Distribution of cGMP-dependent protein kinase type 1 and its isoforms in the mouse brain and retina. Neuroscience 135, pp. 863-868. Fulltext not available.

Schlossmann, Jens, Feil, R. and Hofmann, F. (2005) Insights into cGMP signaling derived from cGMP Kinase knockout mice. Frontiers in Bioscience 10, pp. 1279-1289. Fulltext not available.

Werner, C.G., Godrey, V., Arnold, R.R., Featherstone, G.L., Bender, D., Schlossmann, Jens, Schiemann, M., Hofmann, F. and Pryzwansky, K.B. (2005) Neutrophil dysfunction in guanosine 3',5'-cyclic monophosphate-dependent protein kinase I-deficient mice. Journal of Immunology 175, pp. 1919-1929. Fulltext not available.

Schlossmann, Jens and Hofmann, F. (2005) cGMP-dependent protein kinases in drug discovery. Drug Discovery Today 10, pp. 627-634. Fulltext not available.

2004

Geiselhöringer, A., Gaisa, M., Hofmann, F. and Schlossmann, Jens (2004) Distribution of IRAG and cGKI-isoforms in murine tissues. FEBS Letters 575, pp. 19-22. Fulltext not available.

Geiselhöringer, A., Werner, M., Sigl, K., Smital, P., Wörner, R., Acheo, L., Stieber, J., Weinmeister, P., Feil, R., Feil, S., Wegener, J., Hofmann, F. and Schlossmann, Jens (2004) IRAG is essential for relaxation of receptor-triggered smooth muscle contraction by cGMP Kinase. EMBO Journal 23, pp. 4222-4231. Fulltext not available.

Fritsch, R.M., Saur, D., Kurjak, M., Oesterle, D., Schlossmann, Jens, Geiselhöringer, A., Hofmann, F. and Allescher, H. D. (2004) InsP3R-associated cGMP kinase substrate (IRAG) is essential for nitric oxide-induced inhibition of calcium signaling in human colonic smooth muscle. J. Biol. Chem. 279, pp. 12551-12559. Fulltext not available.

Dove, Stefan, Elz, Sigurd, Seifert, Roland and Buschauer, Armin (2004) Structure-Activity Relationships of Histamine H_2 Receptor Ligands,. Mini-Rev. Med. Chem. 4 (9), pp. 941-954. Fulltext not available.

2003

Koller, A., Schlossmann, Jens, Ashman, K., Uttenweiler-Joseph, S., Ruth, P. l. and Hofmann, F. (2003) Association of phospholamban with a cGMP kinase signaling complex. Biochemical and Biophysical Research Communications : Biochem. Biophys. Res. Commun. 300, pp. 155-160. Fulltext not available.

Seifert, Roland, Wenzel-Seifert, Katharina, Bürckstümmer, Tilmann, Pertz, Heinz H., Schunack, Walter, Dove, Stefan, Buschauer, Armin and Elz, Sigurd (2003) Multiple differences in agonist and antagonist pharmacology between human and guinea pig histamine H1-receptor,. Journal of Pharmacology and Experimental Therapeutics 305, pp. 1104-1115. Fulltext not available.

Schlossmann, Jens, Feil, R. and Hofmann, F. (2003) Signaling through NO and cGMP-dependent protein kinases. Annals of Medicine 35, pp. 21-27. Fulltext not available.

2002

Feil, R., Gappa, N., Rutz, M., Schlossmann, Jens, Rose, C.R., Konnerth, A., Brummer, S. and Hofmann, F. (2002) Functional Reconstitution of vascular smooth muscle cells with cGMP-dependent protein kinase I isoforms. Circulation Research : Circ. Res. 90, pp. 1080-1086. Fulltext not available.

2001

Kelley, Melissa T., Bürckstümmer, Tilmann, Wenzel-Seifert, Katharina, Dove, Stefan, Buschauer, Armin and Seifert, Roland (2001) Distinct interaction of human and guinea pig histamine H_2-Receptor with guanidine-type agonists,. Molecular Pharmacology 60 (6), pp. 1210-1225. Fulltext not available.

Ammendola, A., Geiselhöringer, A., Hofmann, F. and Schlossmann, Jens (2001) Molecular Determinants of the Interaction between the Inositol 1,4,5-Trisphosphate Receptor-associated cGMP Kinase Substrate (IRAG) and cGMP Kinase Iβ. J. Biol. Chem. 276, pp. 24153-24159. Fulltext not available.

Wenzel-Seifert, Katharina, Kelley, Melissa T., Buschauer, Armin and Seifert, Roland (2001) Similar apparent constitutive activity of human histamine H_2-receptor fused to long and short splice variants of Gsa,. Journal of Pharmacology and Experimental Therapeutics 299 (3), pp. 1013-1020. Fulltext not available.

2000

Schlossmann, Jens, Ammendola, A., Ashman, K., Zong, X, Huber, A., Neubauer, G., Wang, G. X., Allescher, H. D., Korth, M., Wilm, M., Hofmann, F. and Ruth, P. (2000) Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta. Nature 404, pp. 197-201. Fulltext not available.

Hofmann, F., Ammendola, A. and Schlossmann, Jens (2000) Rising behind NO: cGMP-dependent protein kinases. Journal of cell science : J. Cell Sci. 113, pp. 1671-1676. Fulltext not available.

1999

Gaburjakova, M., Schlossmann, Jens and Ondrias, K. (1999) Properties of a new calcium-permeable single channel from tracheal microsomes. Biochimica et Biophysica Acta : BBA. Biomembranes 1417, pp. 25-31. Fulltext not available.

1998

Zhou, X.B., Schlossmann, Jens, Hofmann, F., Ruth, P. and Korth, M. (1998) Regulation of stably expressed and native BK channels from human myometrium by cGMP- and cAMP-dependent protein kinase. Pflügers Archiv : European journal of physiology 436, pp. 725-734. Fulltext not available.

1996

Zhou, X. B., Ruth, P., Schlossmann, Jens, Hofmann, F. and Korth, M. (1996) Protein Phosphatase 2A Is Essential for the Activation of Ca2+-activated K+ Currents by cGMP-dependent Protein Kinase in Tracheal Smooth Muscle and Chinese Hamster Ovary Cells. Journal of Biological Chemistry : J. Biol Chem 271, pp. 19760-19767. Fulltext not available.

Schlossmann, Jens, Lill, R., Neupert, W. and Court, D. A. (1996) Tom71, a novel homologue of the mitochondrial preprotein receptor Tom70. The journal of biological chemistry : J. Biol. Chem. 271, pp. 17890-17895. Fulltext not available.

1995

Schlossmann, Jens and Neupert, W. (1995) Assembly of the preprotein receptor MOM72/MAS70 into the protein import complex of the outer membrane of mitochondria. J. Biol Chem 270, pp. 27116-27121. Fulltext not available.

Hagelüken, Astrid, Burde, Rahel, Nürnberg, Bern, Harhammer, R., Buschauer, Armin and Seifert, Roland (1995) Cationic-amphiphilic arpromidine-derived guanidines and a histamine trifluoromethyl-toluidide derivative may activate pertussis toxin-sensitive G-proteins by a receptor-independent mechanism. Naunyn Schmiedeberg's Arch. Pharmacol. 351, pp. 305-308. Fulltext not available.

1994

Klinker, J. F., Schwaner, I., Offermanns, S., Hagelüken, A. and Seifert, Roland (1994) Differential activation of dibutyryl cAMP-differentiated HL-60 human leukemia cells by chemoattractants. Biochemical pharmacology 48 (10), pp. 1857-1864.

Wenzel-Seifert, K., Schächtele, C., Hummel, R., Grünbaum, L. and Seifert, Roland (1994) Evidence that inhibition of phorbol ester-induced superoxide anion formation by cyclosporin A in phagocytes is not mediated by direct inhibition of protein kinase C. Biochemical pharmacology 48 (5), pp. 859-864.

Seifert, Roland, Grünbaum, L. and Schultz, Günter (1994) Histamine H1-receptors in HL-60 monocytes are coupled to Gi-proteins and pertussis toxin-insensitive G-proteins and mediate activation of Ca2+ influx without concomitant Ca2+ mobilization from intracellular stores. Naunyn-Schmiedeberg's archives of pharmacology 349 (4), pp. 355-361.

Musgrave, I. F. and Seifert, Roland (1994) Human neutrophils and HL-60 cells do not possess alpha 2-adrenoceptors. Biochemical pharmacology 47 (2), pp. 233-239.

Hagelüken, A., Grünbaum, L., Nürnberg, B., Harhammer, R., Schunack, W. and Seifert, Roland (1994) Lipophilic beta-adrenoceptor antagonists and local anesthetics are effective direct activators of G-proteins. Biochemical pharmacology 47 (10), pp. 1789-1795.

Musgrave, I. F., Seifert, Roland and Schultz, Günter (1994) Maitotoxin activates cation channels distinct from the receptor-activated non-selective cation channels of HL-60 cells. The Biochemical journal 301 ( Pt 2, pp. 437-441.

Klinker, J. F., Hagelüken, A., Grünbaum, L., Heilmann, I., Nürnberg, B., Harhammer, R., Offermanns, S., Schwaner, I., Ervens, J, Wenzel-Seifert, K, Müller, T. and Seifert, Roland (1994) Mastoparan may activate GTP hydrolysis by Gi-proteins in HL-60 membranes indirectly through interaction with nucleoside diphosphate kinase. The Biochemical journal 304 ( Pt 2, pp. 377-383.

Wenzel-Seifert, K., Schächtele, C. and Seifert, Roland (1994) N-protein kinase C isoenzymes may be involved in the regulation of various neutrophil functions. Biochemical and biophysical research communications 200 (3), pp. 1536-1543.

Naim, M., Seifert, Roland, Nürnberg, B., Grünbaum, L. and Schultz, Günter (1994) Some taste substances are direct activators of G-proteins. The Biochemical journal 297 ( Pt 3, pp. 451-454.

Schlossmann, Jens, Dietmeier, K., Pfanner, N. and Neupert, W. (1994) Specific recognition of mitochondrial preproteins by the cytosolic domain of the import receptor MOM72. The journal of biological chemistry : J. Biol.Chem. 269, pp. 11893-11901. Fulltext not available.

Berger, M., Offermanns, S., Seifert, Roland and Schultz, Günter (1994) Synthetic lipopeptide Pam3CysSer(Lys)4 is an effective activator of human platelets. The American journal of physiology 266 (6 Pt 1), C1684-C1691.

Seifert, Roland, Hagelüken, A., Höer, A., Höer, D., Grünbaum, L., Offermanns, S., Schwaner, I., Zingel, V., Schunack, W. and Schultz, Günter (1994) The H1 receptor agonist 2-(3-chlorophenyl)histamine activates Gi proteins in HL-60 cells through a mechanism that is independent of known histamine receptor subtypes. Molecular Pharmacology 45 (4), pp. 578-586.

Tsang, K. W., Roberts, P., Read, R. C., Kees, Frieder, Wilson, R. and Cole, P. J. (1994) The concentrations of clarithromycin and its 14-hydroxy metabolite in sputum of patients with bronchiectasis following single dose oral administration. The Journal of antimicrobial chemotherapy 33 (2), pp. 289-297.

Honeybourne, D., Kees, Frieder K., Andrews, J. M., Baldwin, D. and Wise, R. (1994) The levels of clarithromycin and its 14-hydroxy metabolite in the lung. The European respiratory journal 7 (7), pp. 1275-1280.

1993

Sedlmayr, T., Petersen, F., Raasch, W. and Kees, Frieder K. (1993) Clarithromycin, ein neues Makrolid-Antibiotikum. Wirksamkeit bei puerperalen Infektionen und Übertritt in die Muttermilch [Clarithromycin, a new macrolide antibiotic. Effectiveness in puerperal infections and pharmacokinetics in breast milk]. Geburtshilfe und Frauenheilkunde 53 (7), pp. 488-491.

Wenzel-Seifert, Katharina and Seifert, Roland (1993) Cyclosporin H is a potent and selective formyl peptide receptor antagonist. Comparison with N-t-butoxycarbonyl-L-phenylalanyl-L-leucyl-L-phenylalanyl-L- leucyl-L-phenylalanine and cyclosporins A, B, C, D, and E. The Journal of Immunology 150 (10), pp. 4591-4599.

Klinker, J. F., Höer, A., Schwaner, I., Offermanns, S., Wenzel-Seifert, Katharina and Seifert, Roland (1993) Lipopeptides activate Gi-proteins in dibutyryl cyclic AMP-differentiated HL-60 cells. The Biochemical journaL 296 ( Pt 1, pp. 245-251.

Wenzel-Seifert, Katharina and Seifert, Roland (1993) Partial inhibition of human neutrophil activation by FK-506 at supratherapeutic concentrations. Naunyn-Schmiedeberg's archives of pharmacology 348 (1), pp. 7-13.

Grobecker, H. F. and Kees, Frieder K. (1993) Pharmacokinetic parameters and haemodynamic actions of midodrine in young volunteers. International angiology : a journal of the International Union of Angiology 12 (2), pp. 119-124.

Musgrave, I. F., Genieser, H. G., Maronde, E. and Seifert, Roland (1993) Preparations of Rp-cyclic adenosine 3',5'-phosphorothioate (Rp-cAMPS) can contain biologically active amounts of adenosine. FEBS letters 318 (3), pp. 227-230.

Dietmeier, K., Zara, V., Voos, W., Schlossmann, Jens, Moczko, M. and Pfanner, N. (1993) Targeting and translocation of the phosphate carrier/p32 to the inner membrane of yeast mitochondria. The journal of biological chemistry : J. Biol. Chem. 268, pp. 25958-25964. Fulltext not available.

1992

Dominiak, P., Kees, Frieder K., Welzel, D. and Grobecker, H. (1992) Cardiovascular parameters and catecholamines in volunteers during passive orthostasis. Influence of antihypotensive drugs. Arzneimittel-Forschung 42 (5), pp. 637-642.

Krautwurst, D., Seifert, Roland, Hescheler, J. and Schultz, Günter (1992) Formyl peptides and ATP stimulate Ca2+ and Na+ inward currents through non-selective cation channels via G-proteins in dibutyryl cyclic AMP-differentiated HL-60 cells. Involvement of Ca2+ and Na+ in the activation of beta-glucuronidase release and superoxide production. The Biochemical journal 288 ( Pt 3, pp. 1025-1035.

Klinz, F. J., Seifert, Roland, Schwaner, I., Gausepohl, H., Frank, R. and Schultz, Günter (1992) Generation of specific antibodies against the rap1A, rap1B and rap2 small GTP-binding proteins. Analysis of rap and ras proteins in membranes from mammalian cells. European journal of biochemistry 207 (1), pp. 207-213.

Seifert, Roland, Höer, Ariane, Offermann, Stefan, Buschauer, Armin and Schunack, Walter (1992) Histamine increases Ca^2+ in dibutyryl cyclic AMP-differentiated HL-60 cells via H_1-receptors and is an incomplete secretagogue. Mol. Pharmacol. 42, pp. 227-234.

Seifert, Roland, Höer, Ariane, Schwaner, Ingo and Buschauer, Armin (1992) Histamine increases cytosolic Ca^2+ in HL-60 promyelocytes predominantly via H_2-receptors with an unique agonist/antagonist profile and induces functional differentiation. Molecular Pharmacology 42, pp. 235-241.

Seifert, Roland, Serke, S., Huhn, D., Bessler, W. G., Hauschildt, S., Metzger, J., Wismüller, K. H. and Jung, G. (1992) Incomplete functional differentiation of HL-60 leukemic cells by synthetic lipopeptides. Partial inhibition by pertussis toxin of enhanced superoxide formation. European journal of biochemistry / FEBS 203 (1-2), pp. 143-151.

Offermanns, S., Seifert, Roland, Metzger, J. W., Jung, G., Lieberknecht, A., Schmidt, U. and Schultz, Günter (1992) Lipopeptides are effective stimulators of tyrosine phosphorylation in human myeloid cells. Biochemical Journal 282 ( Pt 2, pp. 551-7.

Söllner, T., Rassow, J., Wiedmann, T., Schlossmann, Jens, Neupert, W. and Pfanner, N. (1992) Mapping of the protein import machinery in the mitochondrial outer membrane by crosslinking of translocation intermediates. Nature 355, pp. 84-87. Fulltext not available.

Ervens, J. and Seifert, Roland (1992) Molsidomine inhibits the chemoattractant-induced respiratory burst in human neutrophils via a no-independent mechanism. Biochemical pharmacology 44 (4), pp. 637-644.

Kees, Frieder K. (1992) Orale Cephalosporine [Oral cephalosporins]. Medizinische Monatsschrift für Pharmazeuten 15 (1), pp. 2-10.

Schwaner, I., Seifert, Roland and Schultz, Günter (1992) Receptor-mediated increases in cytosolic Ca2+ in the human erythroleukaemia cell line involve pertussis toxin-sensitive and -insensitive pathways. The Biochemical journal 281 ( Pt 2, pp. 301-307.

Kees, Frieder K., Raasch, W. and Grobecker, H.F. (1992) Strukturelle Charakterisierung eines unbekannten Metaboliten von Ciprofloxacin [Structural characterization of an unknown metabolite of ciprofloxacin]. Arzneimittel-Forschung 42 (4), pp. 570-575.

Keil, P., Schlossmann, Jens and Pfanner, N. (1992) Targeting und translocation of mitochondrial precursor proteins. Antonie van Leeuwenhoek J. Microbiol. Serol. 61, pp. 135-142. Fulltext not available.

Schwaner, I., Seifert, Roland and Schultz, Günter (1992) The prostacyclin analogues, cicaprost and iloprost, increase cytosolic Ca2+ concentration in the human erythroleukemia cell line, HEL, via pertussis toxin-insensitive G-proteins. Eicosanoids 5 Suppl, S10-512. Fulltext not available.

1991

Kees, Frieder K., Lukassek, U., Naber, K. G. and Grobecker, H. (1991) Comparative investigations on the bioavailability of cefuroxime axetil. Arzneimittel-Forschung 41 (8), pp. 843-846.

Seifert, Roland and Schultz, Günter (1991) The superoxide- forming NADPH oxidase of phagocytes: an enzyme system regulated by multiple mechanisms. Reviews of physiology, biochemistry, and pharmacology, 117. Springer, Berlin. ISBN 3-540-53663-9, 0-387-53663-9.

1990

Seifert, Roland, Schultz, Günter, Richter-Freund, M., Metzger, J., Wiesmüller, K. H., Jung, G., Bessler, W. G. and Hauschildt, S. (1990) Activation of superoxide formation and lysozyme release in human neutrophils by the synthetic lipopeptide Pam3Cys-Ser-(Lys)4. Involvement of guanine-nucleotide-binding proteins and synergism with chemotactic peptides. The Biochemical journal 267 (3), pp. 795-802.

Jungblut, P. R. and Seifert, Roland (1990) Analysis by high-resolution two-dimensional electrophoresis of differentiation-dependent alterations in cytosolic protein pattern of HL-60 leukemic cells. Journal of biochemical and biophysical methods 21 (1), pp. 47-58.

Burde, Rahel, Buschauer, Armin and Seifert, Roland (1990) Characterization of histamine H_2-receptors in human neutrophils with a series of guanidine analogues of impromidine: Are cell type-specific H_2-receptors involved in the regulation of NADPH oxidase? Naunyn-Schmiedeberg's Archives of Pharmacology 341, pp. 455-461.

Kees, Frieder K., Raasch, W., Steger, M. and Grobecker, H. (1990) High-performance liquid chromatographic assay for cefotiam and d3-cefotiam in human serum. Journal of Chromatography B 525 (2), pp. 484-489.

Wenzel-Seifert, Katharina and Seifert, Roland (1990) Nucleotide-, chemotactic peptide- and phorbol ester-induced exocytosis in HL-60 leukemic cells. Immunobiology 181 (4-5), pp. 298-316.

Kees, Frieder K. and Naber, K. G. (1990) Pharmakokinetik von Cefixim bei Probanden und ein Literaturvergleich mit neuen Ester Prodrug Cephalosporinen [Pharmacokinetics of cefixime in volunteers and a literature comparison with the new ester prodrug cephalosporins]. Infection 18 Suppl 3, S150-S154.

Kees, Frieder K., Naber, K. G., Sigl, G., Ungethüm, W. and Grobecker, H. J. (1990) Relative bioavailability of three cefixime formulations. Arzneimittel-Forschung 40 (3), pp. 293-297.

Korting, H. C., Schäfer-Korting, M., Kees, Frieder K., Lukacs, A. and Grobecker, H. (1990) Skin tissue fluid levels of cefotiam in healthy man following oral cefotiam hexetil. European journal of clinical pharmacology 39 (1), pp. 33-36.

Kees, Frieder K., Dehner, R., Dittrich, W., Raasch, W. and Grobecker, H. J. (1990) Untersuchungen zur Bioverfügbarkeit von Doxycy [The bioavailability of doxycycline]. Arzneimittel-Forschung 40 (9), pp. 1039-1043.

1989

Seifert, Roland, Burde, R. and Schultz, Günter (1989) Activation of NADPH oxidase by purine and pyrimidine nucleotides involves G proteins and is potentiated by chemotactic peptides. The Biochemical journal 259 (3), pp. 813-819.

Engel, K. J., Schmidt, W., Sonntag, H. G. and Kees, Frieder K. (1989) Comparative clinical and pharmacokinetic aspects of cefotetan versus cefoxitin plus metronidazole in vaginal hysterectomy. Journal of chemotherapy 1 (4 Supl), pp. 1053-1056. Fulltext not available.

Seifert, Roland, Jungblut, P. and Schultz, Günter (1989) Differential expression of cytosolic activation factors for NADPH oxidase in HL-60 leukemic cells. Biochemical and biophysical research communications 161 (3), pp. 1109-1117.

Naber, K. G., Sörgel, F., Kees, Frieder K., Schumacher, H., Sigl, G., Zürcher, J. and Berger, S. (1989) Enoxacin-Konzentrationen in der Samenflüssigkeit, im Prostatasekret und im Prostataadenomgewebe nach oraler Gabe oder intravenöser Infusion [Enoxacin concentration in seminal fluid, in prostate secretions and in prostatic adenoma tissue following oral administration or intravenous infusion]. Infection 17 Suppl 1, S30-S66.

Schmidt, H. H., Seifert, Roland and Böhme, E. (1989) Formation and release of nitric oxide from human neutrophils and HL-60 cells induced by a chemotactic peptide, platelet activating factor and leukotriene B4. FEBS letters 244 (2), pp. 357-360.

Rudolph, U., Koesling, D., Hinsch, K. D., Seifert, Roland, Bigalke, M., Schultz, Günter and Rosenthal, W. (1989) G-protein alpha-subunits in cytosolic and membranous fractions of human neutrophils. Molecular and cellular endocrinology 63 (1-2), pp. 143-153.

Burde, Rahel, Seifert, Roland, Buschauer, Armin and Schultz, Günther (1989) Histamine inhibits activation of human neutrophils and HL-60 leukemic cells via H_2-receptors. Naunyn-Schmiedeberg's archives of pharmacology 340, pp. 671-678.

Seifert, Roland and Schultz, Günter (1989) Involvement of pyrimidinoceptors in the regulation of cell functions by uridine and by uracil nucleotides. Trends in pharmacological sciences 10 (9), pp. 365-369.

Seifert, Roland, Burde, R. and Schultz, Günter (1989) Lack of effect of opioid peptides, morphine and naloxone on superoxide formation in human neutrophils and HL-60 leukemic cells. Naunyn-Schmiedeberg's archives of pharmacology 340 (1), pp. 101-106.

Kees, Frieder K., Naber, K. G., Meyer, G. P. and Grobecker, H. (1989) Pharmacokinetics of ciprofloxacin in elderly patients. Arzneimittel-Forschung 39 (4), pp. 523-527.

Naber, K. G., Sörgel, F., Kees, Frieder K., Jaehde, U. and Schumacher, H. (1989) Pharmacokinetics of ciprofloxacin in young (healthy volunteers) and elderly patients, and concentrations in prostatic fluid, seminal fluid, and prostatic adenoma tissue following intravenous administration. The American journal of medicine 87 (5supl1), S57-S59.

Seifert, Roland, Wenzel, Katharina, Eckstein, F. and Schultz, Günter (1989) Purine and pyrimidine nucleotides potentiate activation of NADPH oxidase and degranulation by chemotactic peptides and induce aggregation of human neutrophils via G proteins. European journal of biochemistry / FEBS 181 (1), pp. 277-285.

Kujath, P., Düsel, W., Bruch, H. P. and Kees, Frieder K. (1989) The pharmacokinetic properties of cefotetan and its relevance for prophylaxis in elective colorectal surgery. Journal of chemotherapy 1 (4 Supl), pp. 1002-1004. Fulltext not available.

1988

Seifert, Roland, Schächtele, C., Rosenthal, W. and Schultz, Günter (1988) Activation of protein kinase C by cis- and trans-fatty acids and its potentiation by diacylglycerol. Biochemical and biophysical research communications 154 (1), pp. 20-26.

Engel, K. J., Schmidt, W., Sonntag, H. G. and Kees, Frieder K. (1988) Comparative clinical and pharmacokinetic aspects of cefotetan versus cefoxitin plus metronidazole in vaginal hysterectomy. Chemioterapia 7 (4), pp. 256-260. Fulltext not available.

Naber, K. G., Sörgel, F., Kees, Frieder K., Schumacher, H., Metz, R. and Grobecker, H. (1988) In-vitro activity of fleroxacin against isolates causing complicated urinary tract infections and concentrations in seminal and prostatic fluid and in prostatic adenoma tissue. The Journal of antimicrobial chemotherapy 22 Suppl D, pp. 199-207.

Kees, Frieder K., Naber, K. G., Schumacher, H. and Grobecker, H. (1988) Penetration of fleroxacin into prostatic secretion and prostatic adenoma tissue. Chemotherapy 34 (6), pp. 437-443. Fulltext not available.

Schächtele, C., Seifert, Roland and Osswald, H. (1988) Stimulus-dependent inhibition of platelet aggregation by the protein kinase C inhibitors polymyxin B, H-7 and staurosporine. Biochemical and biophysical research communications 151 (1), pp. 542-547.

Seifert, Roland and Schächtele, C. (1988) Studies with protein kinase C inhibitors presently available cannot elucidate the role of protein kinase C in the activation of NADPH oxidase. Biochemical and biophysical research communications 152 (2), pp. 585-592.

Kujath, P., Düsel, W., Bruch, H. P. and Kees, Frieder K. (1988) The pharmacokinetic properties of cefotetan and its relevance for prophylaxis in elective colorectal surgery. Chemioterapia 7 (4), pp. 229-232. Fulltext not available.

Seifert, Roland, Rosenthal, W., Schultz, Günter, Wieland, T., Gierschick, P. and Jakobs, K. H. (1988) The role of nucleoside-diphosphate kinase reactions in G protein activation of NADPH oxidase by guanine and adenine nucleotides. European journal of biochemistry / FEBS 175 (1), pp. 51-55.

1987

Seifert, Roland, Schächtele, C. and Schultz, Günter (1987) Activation of protein kinase C by cis- and trans-octadecadienoic acids in intact human platelets and its potentiation by diacylglycerol. Biochemical and biophysical research communications 149 (2), pp. 762-768.

Naber, K., Kees, Frieder K., Denk, K., Bauernfeind, A. and Grobecker, H. (1987) Carumonam versus ceftazidime: in vitro activity, pharmacokinetics in elderly patients, safety and therapeutic efficacy in the treatment of complicated urinary tract infections. Chemioterapia 6 (2 Supl), pp. 517-518. Fulltext not available.

Seifert, Roland and Schultz, Günter (1987) Fatty-acid-induced activation of NADPH oxidase in plasma membranes of human neutrophils depends on neutrophil cytosol and is potentiated by stable guanine nucleotides. European journal of biochemistry / FEBS 162 (3), pp. 563-569.

Naber, K. G., Adam, D. and Kees, Frieder K. (1987) In vitro activity and concentrations in serum, urine, prostatic secretion and adenoma tissue of ofloxacin in urological patients. Drugs 34 Suppl 1, S44-S50. Fulltext not available.

Seifert, Roland and Schultz, Günter (1987) Reversible activation of NADPH oxidase in membranes of HL-60 human leukemic cells. Biochemical and biophysical research communications 146 (3), pp. 1296-1302.

Kees, Frieder K., Dominiak, P. and Grobecker, H. (1987) Untersuchungen zur Bioverfügbarkeit von Heptaminol bei Probanden [Bioavailability of heptaminol in healthy subjects]. Arzneimittel-Forschung 37 (10), pp. 1182-1185.

Grobecker, H., Kees, Frieder K., Linden, M., Schrader, E. and Welte, S. (1987) Untersuchungen zur Bioverfügbarkeit von Midodrin und 2,5- Dimethoxyphenyl-ß-aminoethanol-hydrochlorid [The bioavailability of midodrin and alpha-2,5-dimethoxyphenyl-beta-aminoethanol hydrochloride]. Arzneimittel-Forschung 37 (4), pp. 447-450.

1986

Dominiak, P., Kees, Frieder K. and Grobecker, H. (1986) Circulating and tissue catecholamines in rats with chronic neurogenic hypertension. Basic research in cardiology 81 (1), pp. 20-28.

Seifert, Roland, Rosenthal, W. and Schultz, Günter (1986) Guanine nucleotides stimulate NADPH oxidase in membranes of human neutrophils. FEBS letters 205 (1), pp. 161-165.

Martinez, C., Dominiak, P., Kees, Frieder K. and Grobecker, H. (1986) Inhibition of monoamine oxidase by viloxazine in rats. Arzneimittel-Forschung 36 (5), pp. 800-803.

Seifert, Roland (1986) Nikotinamidmethylierung in normalen Geweben und Tumorzellen von Ratte und Maus. PhD, Berlin, Freie Universität.

Naber, K. G., Dette, G. A., Kees, Frieder K., Knothe, H. and Grobecker, H. (1986) Pharmacokinetics, in-vitro activity, therapeutic efficacy and clinical safety of aztreonam vs. cefotaxime in the treatment of complicated urinary tract infections. The Journal of antimicrobial chemotherapy 17 (4), pp. 517-527.

1985

Grobecker, H., Gessler, I., Delius, W., Dominiak, P. and Kees, Frieder K. (1985) Effect of ketanserin on hemodynamics, plasma-catecholamine concentrations, and serotonin uptake by platelets in volunteers and patients with congestive heart failure. Journal of cardiovascular pharmacology 7, Suppl 7, S102-S104.

Kees, Frieder K., Naber, K. G., Bartoschik-Wich, B., Stockmann, P., Meyer, G. P. and Grobecker, H. (1985) High-performance liquid chromatography analysis of mezlocillin, piperacillin, their degradation products, and of ioxitalamic acid in plasma and urine of healthy volunteers. Arzneimittel-Forschung 35 (7), pp. 1099-1104.

Dominiak, P., Kees, Frieder K. and Grobecker, H. (1985) Sympathoadrenal dysfunction in rats with chronic neurogenic hypertension. European journal of pharmacology 107 (2), pp. 263-266.

1984

Dominiak, P., Kees, Frieder K. and Grobecker, H. (1984) Changes in peripheral and central catecholaminergic and serotoninergic neurons of rats after acute and subacute administration of nicotine. Klinische Wochenschrift. Supplementum 62 Suppl 2, pp. 76-80. Fulltext not available.

Kees, Frieder K., Grobecker, H. and Naber, K. G. (1984) High-performance liquid chromatographic analysis of cefotetan epimers in human plasma and urine. Journal of Chromatography B 305 (2), pp. 363-371.

1983

Schleicher, E. D., Kees, Frieder K. and Wieland, O. H. (1983) Analysis of total urinary catecholamines by liquid chromatography: methodology, routine experience and clinical interpretations of results. Clinica chimica acta 129 (3), pp. 295-302.

Kees, Frieder K., Strehl, E., Dominiak, P., Grobecker, H., Seeger, K., Seidel, G., Neuhaus, B. and Safrany, L. (1983) Cefotaxime and desacetyl cefotaxime in human bile. Infection 11 (2), pp. 118-120.

Naber, K. G., Kees, Frieder K. and Grobecker, H. (1983) Ceftazidime: pharmacokinetics in young volunteers versus elderly patients and therapeutic efficacy with complicated urinary tract infections. The Journal of antimicrobial chemotherapy 12 Suppl A, pp. 41-45.

1981

Kees, Frieder K., Strehl, E., Seeger, K., Seidel, G., Dominiak, P. and Grobecker, H. (1981) Comparative determination of cefotaxime and desacetyl cefotaxime in serum and bile by bioassay and high-performance liquid chromatography. Arzneimittel-Forschung 31 (2), pp. 362-365.

1976

Kees, Frieder K. (1976) Thiaziridindioxide, Thiadiaziridindioxide und ein Beitrag zur Staudinger-Pfenninger-Reaktion. PhD, Univ. Würzburg. Fulltext not available.

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