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5-Carboxamidotryptamin-Derivate als Liganden für 5-HT7- und 5-HT2A-Rezeptoren: Synthese und In-vitro-Pharmakologie

Matzdorf, Thorsten (2010) 5-Carboxamidotryptamin-Derivate als Liganden für 5-HT7- und 5-HT2A-Rezeptoren: Synthese und In-vitro-Pharmakologie. PhD, Universität Regensburg.

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Date of publication of this fulltext: 10 Mar 2010 14:26

Abstract (German)

Die vorliegende Arbeit umfasst die organische Synthese und funktionelle in-vitro-pharmakologische Untersuchung von Derivaten des 5-Carboxamidotryptamin (5-CT) als Liganden an Serotonin(5-Hydroxytryptamin)-Rezeptoren des Subtyps 5-HT7 und 5-HT2A. Die Lokalisation dieser Serotoninrezeptoren erstreckt sich insbesondere auf das Zentralnervensystem sowie auf vaskuläres Gewebe. Ziel der Arbeit war die ...


Translation of the abstract (English)

The present dissertation contains the synthesis and functional in-vitro-pharma-cological investigation of close derivatives of 5-carboxamidotryptamine (5-CT) as ligands at serotonin(5-hydroxytryptamine) 5-HT7 and 5-HT2A receptors. These 5-HT receptor subtypes are preferentially located in the central nervous system and in vascular tissues. Scope of this thesis was the development of versatile ...


Export bibliographical data

Item type:Thesis of the University of Regensburg (PhD)
Date:10 March 2010
Referee:Prof. Dr. Sigurd Elz
Date of exam:23 January 2009
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry I (Prof. Elz)
Keywords:Präparative Chemie , Pharmazie , Tryptaminderivate , Serotonin , Ligand <Biochemie> , Agonist , 5-CT , 5-HT7 , 5-HT2A , Rattenschwanzarterie , Ferkelpulmonalarterie , 5-CT , 5-HT7 , 5-HT2A , rat tail artery , weaned pig pulmonary artery
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:13400
Owner only: item control page


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