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N,N'-Dialkyl-1,2-bis(hydroxyphenyl)ethylenediamines and N,N'-dialkyl-4,5-bis(4-hydroxyphenyl)imidazolidines. Syntheses and evaluation of their mammary tumor inhibiting activity

Angerer, Erwin von ; Egginger, Guenter ; Kranzfelder, Gerhard ; Bernhauer, Horst ; Schönenberger, Helmut
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Date of publication of this fulltext: 17 May 2010 12:12


Abstract

Diastereomeric N,”-dialkyl- 1,2-bis(hydroxyphenyl)ethylenediamines (5) were synthesized and tested for their affinity for the estradiol receptor. Only the (&)-1,2-bis(4-hydroxyphenyl)ethylenediamines with the alkyl groups C3H7 [ (&)-5c, K, = 1.1 X lo6)],C ,H9 [(&)-5e,K=, 3.6 X lo6], and CSHll [(*)-5h, K, = 2.2 X lo6] showed a marked affinity, which is mainly due to the (+) enantiomers [e.g., ...

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