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2-(Hydroxyphenyl)indoles: a new class of mammary tumor-inhibiting compounds

Angerer, Erwin von and Prekajac, Jelica (1983) 2-(Hydroxyphenyl)indoles: a new class of mammary tumor-inhibiting compounds. Journal of Medicinal Chemistry 26 (1), pp. 113-116.

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l-Allryl-4-chloro-2-(2,6-dichloro-4-hydroxyphenyl)-6-hydroxyindo(l4e,as l kyl =i CHa, CsHs, CaH,) were synthesized by thermolysis of the corresponding NJV’-dialkyl-1,2-diphenylethylenediamineasn d subsequent ether cleavage. They showed an affinity for the estrogen receptor (1% of 178-estradiol) and inhibited the growth of the 9,lO-dimethyl- l,2-benz[u]anthracene (DMBA) induced mammary carcinoma ...


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Item type:Article
Date:January 1983
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
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Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Created at the University of Regensburg:Unknown
Item ID:14972
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