2-(Hydroxyphenyl)indoles: a new class of mammary tumor-inhibiting compounds

DOI zum Zitieren dieses Dokuments:: 10.5283/epub.14972

Angerer, Erwin von ; Prekajac, Jelica

PDF
(490kB) - Nur für Mitarbeiter des Archivs

Veröffentlichungsdatum dieses Volltextes: 17 Mai 2010 12:11

Alternative Links zum Volltext:DOI

Details

Bibliographische Daten exportieren

Zusammenfassung

l-Allryl-4-chloro-2-(2,6-dichloro-4-hydroxyphenyl)-6-hydroxyindo(l4e,as l kyl =i CHa, CsHs, CaH,) were synthesized by thermolysis of the corresponding NJV’-dialkyl-1,2-diphenylethylenediamineasn d subsequent ether cleavage. They showed an affinity for the estrogen receptor (1% of 178-estradiol) and inhibited the growth of the 9,lO-dimethyl- l,2-benz[u]anthracene (DMBA) induced mammary carcinoma ...