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2-(Hydroxyphenyl)indoles: a new class of mammary tumor-inhibiting compounds

Angerer, Erwin von ; Prekajac, Jelica
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Date of publication of this fulltext: 17 May 2010 12:11


Abstract

l-Allryl-4-chloro-2-(2,6-dichloro-4-hydroxyphenyl)-6-hydroxyindo(l4e,as l kyl =i CHa, CsHs, CaH,) were synthesized by thermolysis of the corresponding NJV’-dialkyl-1,2-diphenylethylenediamineasn d subsequent ether cleavage. They showed an affinity for the estrogen receptor (1% of 178-estradiol) and inhibited the growth of the 9,lO-dimethyl- l,2-benz[u]anthracene (DMBA) induced mammary carcinoma ...

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