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Cellular nanoparticle delivery by G-protein coupled receptors

Hild, Wolfgang (2012) Cellular nanoparticle delivery by G-protein coupled receptors. PhD, Universität Regensburg.

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Date of publication of this fulltext: 14 Jun 2012 08:28

Abstract (English)

Considering the significant benefits that site-specific drug therapy offers, in this work, the potential of G-protein-coupled receptors (GPCRs) as candidates for a new class of targets in the field of drug targeting was investigated. In order to evaluate this potential at the cellular level, nanoparticles were conjugated with specific ligands for the human neuropeptide Y (hNPY) Y1 receptor and ...

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Translation of the abstract (German)

In Anbetracht der signifikanten Vorteile, die eine zielgerichtete Pharmakotherapie bietet, wurde in dieser Arbeit untersucht, welches Potential G-Protein gekoppelte Rezeptoren (GPCRs) als neue Klasse von Zielstrukturen im Bereich des Nanopartikel-Targeting aufweisen. Um dies auf zellulärer Ebene zu bestimmen, wurden Nanopartikel mit Liganden spezifisch für den menschlichen Neuropeptid Y (hNPY) ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:14 June 2012
Referee:Prof. Dr. Achim Göpferich and Prof. Dr. Jörg Heilmann and Prof. Dr. Frank-Michael Matysik
Date of exam:7 May 2010
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich)
Keywords:GPCR, neuropeptide Y, NPY, quantum dot, nanoparticle, drug targeting, uptake
Dewey Decimal Classification:600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:15314
Owner only: item control page

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