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Dibenzo[a,g]quinolizin-8-ones: synthesis, estrogen receptor affinities, and cytostatic activity

Angerer, S. von, Brandl, G., Mannschreck, Albrecht, Weimar, C. and Wiegrebe, Wolfgang (1992) Dibenzo[a,g]quinolizin-8-ones: synthesis, estrogen receptor affinities, and cytostatic activity. Anti-Cancer Drug Design 7, pp. 351-363.

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Date of publication of this fulltext: 12 Jul 2010 07:38


A number of acetoxy-substituted dibenzo[a,g]quinolizin-8-ones were synthesized by the reaction of 1-oxoisoquinolines with substituted homophthalic acid anhydride. All of the derivatives with acetoxy groups in positions 3 and 10 bind to the estrogen receptor. Relative binding affinities (RBA) ranged from 1.8 to 5.6 (estradiol: RBA = 100) when the substituent at C-6 was a short alkyl group. ...


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Item type:Article
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Wiegrebe
Keywords:cytostatic activity/dibenzo[a,g]quinolizin-8-ones/estrogen receptor affinity/synthesis
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:15775
Owner only: item control page


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