Müller, K., Gürster, D., Piwek, S. and Wiegrebe, Wolfgang (1993) Antipsoriatic Anthrones with Modulated Redox Properties, 1. Novel 10-Substituted 1,8-Dihydroxy-9(10H)-anthracenones as Inhibitors of 5-Lipoxygenase. European Journal of Medicinal Chemistry 36 (25), pp. 4099-4107.
| PDF Download (2MB) |
Abstract
The syntheses, the biological evaluation, and the structure-activity relationships of a novel series of l,8-dihydroxy-9(10H)-anthracenones bearing acyl-, alkyl-, or alkylidene-linked aromatic substituents in the 10-position are described. The phenylacyl and phenylalkylidene analogs were far more potent inhibitors of 5-lipoxygenase (5-LO) from bovine polymorphonuclear leukocytes (IC50 values in ...
Export bibliographical data
| Item type: | Article |
|---|---|
| Date: | 1993 |
| Institutions: | Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Wiegrebe |
| Dewey Decimal Classification: | 500 Science > 540 Chemistry & allied sciences |
| Status: | Published |
| Refereed: | Yes, this version has been refereed |
| Created at the University of Regensburg: | Unknown |
| Item ID: | 15784 |
Owner only: item control page
Download Statistics