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Antipsoriatic Anthrones with Modulated Redox Properties, 1. Novel 10-Substituted 1,8-Dihydroxy-9(10H)-anthracenones as Inhibitors of 5-Lipoxygenase

URN to cite this document:
urn:nbn:de:bvb:355-epub-157844
DOI to cite this document:
10.5283/epub.15784
Müller, K. ; Gürster, D. ; Piwek, S. ; Wiegrebe, Wolfgang
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Date of publication of this fulltext: 12 Jul 2010 07:53


Abstract

The syntheses, the biological evaluation, and the structure-activity relationships of a novel series of l,8-dihydroxy-9(10H)-anthracenones bearing acyl-, alkyl-, or alkylidene-linked aromatic substituents in the 10-position are described. The phenylacyl and phenylalkylidene analogs were far more potent inhibitors of 5-lipoxygenase (5-LO) from bovine polymorphonuclear leukocytes (IC50 values in ...

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