Antipsoriatic Anthrones with Modulated Redox Properties, 1. Novel 10-Substituted 1,8-Dihydroxy-9(10H)-anthracenones as Inhibitors of 5-Lipoxygenase

URN to cite this document:: urn:nbn:de:bvb:355-epub-157844
DOI to cite this document:: 10.5283/epub.15784

Müller, K. ; Gürster, D. ; Piwek, S. ; Wiegrebe, Wolfgang

Preview

PDF
(2MB)

Date of publication of this fulltext: 12 Jul 2010 07:53

Details

Item type:	Article
Journal or Publication Title:	European Journal of Medicinal Chemistry
Publisher:	Elsevier
Volume:	36
Number of Issue or Book Chapter:	25
Page Range:	pp. 4099-4107
Date:	1993
Institutions:	Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Wiegrebe
Dewey Decimal Classification:	500 Science > 540 Chemistry & allied sciences
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Unknown
Item ID:	15784

Preview

Export bibliographical data

Abstract

The syntheses, the biological evaluation, and the structure-activity relationships of a novel series of l,8-dihydroxy-9(10H)-anthracenones bearing acyl-, alkyl-, or alkylidene-linked aromatic substituents in the 10-position are described. The phenylacyl and phenylalkylidene analogs were far more potent inhibitors of 5-lipoxygenase (5-LO) from bovine polymorphonuclear leukocytes (IC50 values in ...

Owner only: item control page

Download Statistics

More literature (via CORE)

Details

Preview

Export bibliographical data

Abstract

Abstract

Download Statistics

Downloads

More literature (via CORE)

University Library