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Neue Imidazol- und Indolderivate -
Synthese und biologische in-vitro-Prüfungen

Eswayah, Asma Mohamed (2012) Neue Imidazol- und Indolderivate -
Synthese und biologische in-vitro-Prüfungen.
PhD, Universität Regensburg.

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Date of publication of this fulltext: 16 Aug 2012 09:10

Abstract (German)

Diese Arbeit bestehend aus 2 Teilen. Im ersten Teil sollte eine Reihe von neuen N (3-(4-(Pyridin-3yl)-1H-imidazol-2-ylamino)phenyl)amid-Derivaten synthetisiert werden. Diese Derivate sollten auf ihre inhibitorische Wirkung an PDGF- und FLT3-Rezeptor-Tyrosinkinase getestet werden. Als Leitstruktur für diese Synthese diente der bekannte Tyrosinkinase-Inhibitor Imatinib, welcher eine Gruppe von ...


Translation of the abstract (English)

The thesis is divided into two parts. The first part deals with the synthesis of a series of new N-(3-(4-(pyridine-3yl)-1H-imidazole-2-ylamino)phenyl)amide derivatives. These derivatives were tested for their inhibitory effect on receptor tyrosine kinases. The lead compound for this synthesis was the well known tyrosine kinase inhibitor imatinib, which inhibits a group of tyrosine kinases. In ...


Export bibliographical data

Item type:Thesis of the University of Regensburg (PhD)
Date:16 August 2012
Referee:Prof. Dr. Siavosh Mahboobi
Date of exam:27 July 2010
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry I (Prof. Elz)
Interdisciplinary Subject Network:Not selected
Keywords:Key words for part I: 1H-Imidazol-2-ylamine, pyrimidine, bioisosterism, receptor tyrosine kinases, imatinib, PDGF Key words for part II: SAR study, antibacterial compounds, indole derivatives, resistant Staphylococcus aureus, inflamation, NSAIDs
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:16266
Owner only: item control page


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