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Xanthohumol, a prenylated chalcone derived from hops, inhibits proliferation, migration and interleukin-8 expression of hepatocellular carcinoma cells

Dorn, Christoph , Weiss, Thomas S., Heilmann, Jörg and Hellerbrand, Claus (2010) Xanthohumol, a prenylated chalcone derived from hops, inhibits proliferation, migration and interleukin-8 expression of hepatocellular carcinoma cells. International journal of oncology 36 (2), pp. 435-441.

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Other URL: http://doi.org/10.3892/ijo_00000517


Abstract

Xanthohumol, the major prenylated chalcone found in hops, is well known to exert anti-cancer effects, but information regarding the impact on hepatocellular carcinoma (HCC) cells and potential adverse effects on non-tumorous hepatocytes is limited. Here, we show that xanthohumol at a concn. of 25 micro M induced apoptosis in two HCC cell lines (HepG2 and Huh7). Furthermore, xanthohumol repressed ...

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Item type:Article
Date:2010
Additional Information (public):CAN 153:221485 1-6 Pharmacology 6754-58-1 (Xanthohumol) Role: NPO (Natural product occurrence), PAC (Pharmacological activity), THU (Therapeutic use), BIOL (Biological study), OCCU (Occurrence), USES (Uses) (xanthohumol inhibited proliferation, migration and interleukin-8 expression in human hepatocellular carcinoma cell)
Institutions:Medicine > Lehrstuhl für Innere Medizin I
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann)
Chemistry and Pharmacy > Institute of Pharmacy > Group Clinical Pharmacy (Dr. Dorn)
Identification Number:
ValueType
2010:219362Other
10.3892/ijo_00000517DOI
Keywords:Cytotoxic agents (antiinflammatory xanthohumol inhibited interleukin-8 expression in human hepatocellular carcinoma cell) Carcinoma (hepatocellular xanthohumol inhibited proliferation, migration and interleukin-8 expression in human hepatocellular carcinoma cell) Liver (hepatoma xanthohumol inhibited proliferation, migration and interleukin-8 expression in human hepatocellular carcinoma cell) Antitumor agents (prenylated chalcone xanthohumol derived from Humulus lupulus inhibited proliferation, migration and interleukin-8 expression in human hepatocellular carcinoma cell) Human Humulus lupulus Natural products (xanthohumol derived from Humulus lupulus inhibited proliferation, migration and interleukin-8 expression in human hepatocellular carcinoma cell) Apoptosis (xanthohumol induced apoptosis in human hepatocellular carcinoma cell) Interleukin 8 Role: BSU (Biological study, unclassified), BIOL (Biological study) (xanthohumol inhibited interleukin-8 expression in human hepatocellular carcinoma cell) Cell migration (xanthohumol inhibited migration in human hepatocellular carcinoma cell) Transcription factor NF-kB Role: BSU (Biological study, unclassified), BIOL (Biological study) (xanthohumol inhibited nuclear factor k-B activation in human hepatocellular carcinoma cell) interleukin hepatocellular carcinoma cytotoxic xanthohumol Humulus
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
500 Science > 570 Life sciences
600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:17251
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