Dorn, Christoph 
, Weiss, Thomas S., Heilmann, Jörg und Hellerbrand, Claus
(2010)
Xanthohumol, a prenylated chalcone derived from hops, inhibits proliferation, migration and interleukin-8 expression of hepatocellular carcinoma cells.
International journal of oncology 36 (2), S. 435-441.
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Andere URL zum Volltext: http://doi.org/10.3892/ijo_00000517
Zusammenfassung
Xanthohumol, the major prenylated chalcone found in hops, is well known to exert anti-cancer effects, but information regarding the impact on hepatocellular carcinoma (HCC) cells and potential adverse effects on non-tumorous hepatocytes is limited. Here, we show that xanthohumol at a concn. of 25 micro M induced apoptosis in two HCC cell lines (HepG2 and Huh7). Furthermore, xanthohumol repressed ...
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| Dokumentenart: | Artikel | ||||||
|---|---|---|---|---|---|---|---|
| Datum: | 2010 | ||||||
| Zusätzliche Informationen (Öffentlich): | CAN 153:221485 1-6 Pharmacology 6754-58-1 (Xanthohumol) Role: NPO (Natural product occurrence), PAC (Pharmacological activity), THU (Therapeutic use), BIOL (Biological study), OCCU (Occurrence), USES (Uses) (xanthohumol inhibited proliferation, migration and interleukin-8 expression in human hepatocellular carcinoma cell) | ||||||
| Institutionen: | Medizin > Lehrstuhl für Innere Medizin I Chemie und Pharmazie > Institut für Pharmazie > Lehrstuhl Pharmazeutische Biologie (Prof. Heilmann) Chemie und Pharmazie > Institut für Pharmazie > Arbeitsgruppe Klinische Pharmazie (Dr. Dorn) | ||||||
| Identifikationsnummer: |
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| Stichwörter / Keywords: | Cytotoxic agents (antiinflammatory xanthohumol inhibited interleukin-8 expression in human hepatocellular carcinoma cell) Carcinoma (hepatocellular xanthohumol inhibited proliferation, migration and interleukin-8 expression in human hepatocellular carcinoma cell) Liver (hepatoma xanthohumol inhibited proliferation, migration and interleukin-8 expression in human hepatocellular carcinoma cell) Antitumor agents (prenylated chalcone xanthohumol derived from Humulus lupulus inhibited proliferation, migration and interleukin-8 expression in human hepatocellular carcinoma cell) Human Humulus lupulus Natural products (xanthohumol derived from Humulus lupulus inhibited proliferation, migration and interleukin-8 expression in human hepatocellular carcinoma cell) Apoptosis (xanthohumol induced apoptosis in human hepatocellular carcinoma cell) Interleukin 8 Role: BSU (Biological study, unclassified), BIOL (Biological study) (xanthohumol inhibited interleukin-8 expression in human hepatocellular carcinoma cell) Cell migration (xanthohumol inhibited migration in human hepatocellular carcinoma cell) Transcription factor NF-kB Role: BSU (Biological study, unclassified), BIOL (Biological study) (xanthohumol inhibited nuclear factor k-B activation in human hepatocellular carcinoma cell) interleukin hepatocellular carcinoma cytotoxic xanthohumol Humulus | ||||||
| Dewey-Dezimal-Klassifikation: | 500 Naturwissenschaften und Mathematik > 540 Chemie 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie 600 Technik, Medizin, angewandte Wissenschaften > 615 Pharmazie | ||||||
| Status: | Veröffentlicht | ||||||
| Begutachtet: | Ja, diese Version wurde begutachtet | ||||||
| An der Universität Regensburg entstanden: | Ja | ||||||
| Eingebracht am: | 18 Okt 2010 14:02 | ||||||
| Zuletzt geändert: | 10 Apr 2018 11:15 | ||||||
| Dokumenten-ID: | 17251 |
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