| Item type: | Article | ||||||
|---|---|---|---|---|---|---|---|
| Journal or Publication Title: | International journal of oncology | ||||||
| Publisher: | Athen: Spandidos Publ. | ||||||
| Volume: | 36 | ||||||
| Number of Issue or Book Chapter: | 2 | ||||||
| Page Range: | pp. 435-441 | ||||||
| Date: | 2010 | ||||||
| Additional Information (public): | CAN 153:221485 1-6 Pharmacology 6754-58-1 (Xanthohumol) Role: NPO (Natural product occurrence), PAC (Pharmacological activity), THU (Therapeutic use), BIOL (Biological study), OCCU (Occurrence), USES (Uses) (xanthohumol inhibited proliferation, migration and interleukin-8 expression in human hepatocellular carcinoma cell) | ||||||
| Institutions: | Medicine > Lehrstuhl für Innere Medizin I Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann) Chemistry and Pharmacy > Institute of Pharmacy > Group Clinical Pharmacy (Dr. Dorn) | ||||||
| Identification Number: |
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| Keywords: | Cytotoxic agents (antiinflammatory xanthohumol inhibited interleukin-8 expression in human hepatocellular carcinoma cell) Carcinoma (hepatocellular xanthohumol inhibited proliferation, migration and interleukin-8 expression in human hepatocellular carcinoma cell) Liver (hepatoma xanthohumol inhibited proliferation, migration and interleukin-8 expression in human hepatocellular carcinoma cell) Antitumor agents (prenylated chalcone xanthohumol derived from Humulus lupulus inhibited proliferation, migration and interleukin-8 expression in human hepatocellular carcinoma cell) Human Humulus lupulus Natural products (xanthohumol derived from Humulus lupulus inhibited proliferation, migration and interleukin-8 expression in human hepatocellular carcinoma cell) Apoptosis (xanthohumol induced apoptosis in human hepatocellular carcinoma cell) Interleukin 8 Role: BSU (Biological study, unclassified), BIOL (Biological study) (xanthohumol inhibited interleukin-8 expression in human hepatocellular carcinoma cell) Cell migration (xanthohumol inhibited migration in human hepatocellular carcinoma cell) Transcription factor NF-kB Role: BSU (Biological study, unclassified), BIOL (Biological study) (xanthohumol inhibited nuclear factor k-B activation in human hepatocellular carcinoma cell) interleukin hepatocellular carcinoma cytotoxic xanthohumol Humulus | ||||||
| Dewey Decimal Classification: | 500 Science > 540 Chemistry & allied sciences 500 Science > 570 Life sciences 600 Technology > 615 Pharmacy | ||||||
| Status: | Published | ||||||
| Refereed: | Yes, this version has been refereed | ||||||
| Created at the University of Regensburg: | Yes | ||||||
| Item ID: | 17251 |
Abstract
Xanthohumol, the major prenylated chalcone found in hops, is well known to exert anti-cancer effects, but information regarding the impact on hepatocellular carcinoma (HCC) cells and potential adverse effects on non-tumorous hepatocytes is limited. Here, we show that xanthohumol at a concn. of 25 micro M induced apoptosis in two HCC cell lines (HepG2 and Huh7). Furthermore, xanthohumol repressed ...
Abstract
Xanthohumol, the major prenylated chalcone found in hops, is well known to exert anti-cancer effects, but information regarding the impact on hepatocellular carcinoma (HCC) cells and potential adverse effects on non-tumorous hepatocytes is limited. Here, we show that xanthohumol at a concn. of 25 micro M induced apoptosis in two HCC cell lines (HepG2 and Huh7). Furthermore, xanthohumol repressed proliferation and migration, as well as TNF induced NF-kB activity and interleukin-8 expression in both cell lines at even lower concns. In contrast, xanthohumol concns. up to 100 micro M did not affect viability of primary human hepatocytes in vitro. In summary, our data showed that xanthohumol can ameliorate different pro-tumorigenic mechanisms known to promote HCC progression, indicating its potential as promising therapeutic agent that selectively affects cancer cells.
Metadata last modified: 24 May 2018 12:16
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