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[H2-antagonistic activity of the impromidine analog, cyanoguanidine. 37. H2 antihistaminics]

Elz, Sigurd ; Schunack, W.


In studies on structure-activity relationships among impromidine-like histamine H2-receptor agonists, the synthesis of impromidine analogous guanidines led to the corresponding intermediate cyanoguanidines. The latter are structurally related to cimetidine. For that reason they were tested for H2-antagonistic activity on the isolated guinea-pig atrium. Compound 5h proved to be significantly more ...


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