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[H2-antagonistic activity of the impromidine analog, cyanoguanidine. 37. H2 antihistaminics]

Elz, Sigurd and Schunack, W. (1988) [H2-antagonistic activity of the impromidine analog, cyanoguanidine. 37. H2 antihistaminics]. Arzneimittelforschung 38 (1), pp. 7-10.

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In studies on structure-activity relationships among impromidine-like histamine H2-receptor agonists, the synthesis of impromidine analogous guanidines led to the corresponding intermediate cyanoguanidines. The latter are structurally related to cimetidine. For that reason they were tested for H2-antagonistic activity on the isolated guinea-pig atrium. Compound 5h proved to be significantly more ...


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Item type:Article
Additional Information (public):Elz, S Schunack, W English Abstract In Vitro Research Support, Non-U.S. Gov't Germany, west Arzneimittel-Forschung Arzneimittelforschung. 1988 Jan;38(1):7-10.
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry I (Prof. Elz)
Identification Number:
Keywords:Animals Chemistry Guanidines/*pharmacology Guinea Pigs Heart/*drug effects *Histamine H2 Antagonists Imidazoles/*pharmacology Impromidine Structure-Activity Relationship
Dewey Decimal Classification:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:No
Item ID:17296
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