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Funktionelle Studie der NO/cGMP Signalkaskade in Niere und Thrombozyten

Schinner, Elisabeth (2011) Funktionelle Studie der NO/cGMP Signalkaskade in Niere und Thrombozyten. PhD, Universität Regensburg.

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Date of publication of this fulltext: 04 May 2011 09:23

Abstract (German)

Im ersten Teil dieser Arbeit wurde die renale Funktion von cGKI unter physiologischen und pathophysiologischen Bedingungen untersucht. Sowohl in Fibroblasten des Interstitiums als auch in Mesangialzellen des Glomerulus wurde immunhistochemisch eine hohe cGKI-Expression detektiert. Die Rolle von cGMP/cGKI für die interstitielle Fibrose wurde mittels unilateraler Ureter Ligation (UUL) untersucht. ...

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Translation of the abstract (English)

In the first part, we analysed the renal function of NO/cGMP/cGKI under physiological conditions and in the renal fibrosis. Both isoforms - cGKIα and cGKIβ - were immunhistochemically detected in the cortical interstitium, but cGKIβ expression is lacking in the medullary interstitium. The different localization of cGKIα and cGKIβ in the medullary interstitium strongly suggested a differential ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:4 May 2011
Referee:Prof. Dr. Jens Schlossmann and Prof. Dr. Armin Kurtz
Date of exam:19 November 2010
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann, formerly Prof. Seifert)
Interdisciplinary Subject Network:Not selected
Keywords:NO, cGMP, cGKI, IRAG, Niere, Fibrose, Thrombozyten
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:18538
Owner only: item control page

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