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Growth-dependent regulation of ribosome biogenesis and the role of Rrn3p in RNA polymerase I transcription

Steinbauer, Robert (2011) Growth-dependent regulation of ribosome biogenesis and the role of Rrn3p in RNA polymerase I transcription. PhD, Universität Regensburg.

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Date of publication of this fulltext: 04 Mar 2011 14:28

Abstract (English)

Eukaryotic cell growth is tightly linked to the synthesis of new ribosomes, the molecular machineries responsible for protein production. The transcription of a ribosomal precursor RNA (pre-rRNA) by RNA polymerase I (Pol I) constitutes an initial and central step in the complex process of ribosome biogenesis and is therefore one of the main targets for regulation. The initiation of each round of ...

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Translation of the abstract (German)

Das Wachstum eukaryotischer Zellen ist stark abhängig von der Synthese neuer Ribosomen, den molekularen Maschinerien, die für die Herstellung von Proteinen verantwortlich sind. Die Transkription einer ribosomalen Vorläufer-RNA (Prä-rRNA) durch die RNA Polymerase I (Pol I) stellt einen initialen und zentralen Schritt im komplizierten Prozess der Ribosomen-Biogenese dar und ist dadurch einer der ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:4 March 2011
Referee:Prof. Dr. Herbert Tschochner and Prof. Dr. Michael Thomm and Prof. Dr. Wolfgang Seufert
Date of exam:7 February 2011
Institutions:Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie III > Prof. Dr. Herbert Tschochner
Interdisciplinary Subject Network:Not selected
Keywords:Ribosome biogenesis, Pol I, Rrn3p, transcription, TOR, rapamycin, rRNA, ribosomal proteins
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:19842
Owner only: item control page

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