Polymorphic proteins encoded within BZLF1 of defective and standard Epstein-Barr viruses disrupt latency

URN to cite this document:: urn:nbn:de:bvb:355-epub-205348
DOI to cite this document:: 10.5283/epub.20534

Countryman, J. ; Jenson, H. ; Seibl, R. ; Wolf, Hans J. ; Miller, G.

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Date of publication of this fulltext: 15 Apr 2011 08:48

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Abstract

These experiments identify an Epstein-Barr virus-encoded gene product, called ZEBRA (BamHI fragment Z Epstein-Barr replication activator) protein, which activates a switch between the latent and replicative life cycle of the virus. Our previous work had shown that the 2.7-kilobase-pair WZhet piece of rearranged Epstein-Barr virus DNA from a defective virus activated replication when introduced ...