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Polymorphic proteins encoded within BZLF1 of defective and standard Epstein-Barr viruses disrupt latency

URN to cite this document:
Countryman, J. ; Jenson, H. ; Seibl, R. ; Wolf, Hans J. ; Miller, G.
Date of publication of this fulltext: 15 Apr 2011 08:48


These experiments identify an Epstein-Barr virus-encoded gene product, called ZEBRA (BamHI fragment Z Epstein-Barr replication activator) protein, which activates a switch between the latent and replicative life cycle of the virus. Our previous work had shown that the 2.7-kilobase-pair WZhet piece of rearranged Epstein-Barr virus DNA from a defective virus activated replication when introduced ...


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