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Colloidal carriers for intravenous drug targeting: plasma protein adsorption patterns on surface-modified latex particles evaluated by two-dimensional polyacrylamide gel electrophoresis

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Blunk, Torsten ; Hochstrasser, D. F. ; Sanchez, J. C. ; Müller, B. W. ; Müller, R. H.
Date of publication of this fulltext: 27 Jan 2012 07:22


Targeting to specific sites of the body via colloidal carriers is sought in order to reduce drug side effects. The adsorption of plasma proteins on intravenously injected particles is regarded as the key factor in explaining their organ distribution: total bound protein, or, more likely, the presence of specific proteins and their conformation, are expected to influence macrophage uptake. ...


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