Mechanisms of in vivo binding site selection of the hematopoietic master transcription factor PU.1

URN to cite this document:: urn:nbn:de:bvb:355-epub-288166
DOI to cite this document:: 10.5283/epub.28816

Pham, Thu-Hang ; Minderjahn, Julia ; Schmidl, Christian ; Hoffmeister, Helen ; Schmidhofer, Sandra ; Chen, Wei ; Längst, Gernot ; Benner, Christopher ; Rehli, Michael

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Date of publication of this fulltext: 09 Sep 2013 11:51

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Abstract

The transcription factor PU.1 is crucial for the development of many hematopoietic lineages and its binding patterns significantly change during differentiation processes. However, the 'rules' for binding or not-binding of potential binding sites are only partially understood. To unveil basic characteristics of PU.1 binding site selection in different cell types, we studied the binding properties ...