Startseite UR
Babl, Sabrina, Seidel, Julia M., Kugler, Fabian
, Silberhorn, Elisabeth, Ludwig, Anna, Abel, Jonas, Winklbauer, Sophia, Schaub, Niklas, Materna‐Reichelt, Silvia, Honarnejad, Kamran, Stojanović Gužvić, Nataša und Längst, Gernot
(2025)
SARS‐CoV‐2 nucleocapsid protein variants have differential RNA chaperone activity.
The FEBS Journal.
Baumgartl, Conradin, Holzinger, Simon
, Schwartz, Uwe
, Franken, Linda E, Grünewald, Kay, Wodrich, Harald und Längst, Gernot
(2025)
Adenovirus maturation establishes the transcription competent packaging of its genome.
EMBO Reports.
Babl, Sabrina
(2025)
Functional Characterization of the SARS-CoV-2 Nucleocapsid Protein.
Dissertation, Universität Regensburg.
Watzlowik, Maria Theresia, Silberhorn, Elisabeth, Das, Sujaan
, Singhal, Ritwik, Venugopal, Kannan, Holzinger, Simon
, Stokes, Barbara, Schadt, Ella, Sollelis, Lauriane, Bonnell, Victoria A., Gow, Matthew, Klingl, Andreas, Marti, Matthias, Llinás, Manuel, Meissner, Markus und Längst, Gernot
(2025)
Plasmodium blood stage development requires the chromatin remodeller Snf2L.
Nature.
Wernig-Zorc, Sara
, Kugler, Fabian
, Schmutterer, Leo
, Räß, Patrick
, Hausmann, Clemens, Holzinger, Simon
, Längst, Gernot
und Schwartz, Uwe
(2024)
nucMACC: An MNase-seq pipeline to identify structurally altered nucleosomes in the genome.
Science Advances 10 (27), eadm9740.
Bludau, Anna
, Schwartz, Uwe
, Zeitler, Daniela M., Royer, Melanie
, Meister, Gunter
, Neumann, Inga D.
und Menon, Rohit
(2023)
Functional involvement of septal miR-132 in extinction and oxytocin-mediated reversal of social fear.
Molecular Psychiatry.
Schwartz, Uwe
, Komatsu, Tetsuro
, Huber, Claudia, Lagadec, Floriane
, Baumgartl, Conradin, Silberhorn, Elisabeth, Nuetzel, Margit, Rayne, Fabienne, Basyuk, Eugenia
, Bertrand, Edouard, Rehli, Michael, Wodrich, Harald und Laengst, Gernot
(2023)
Changes in adenoviral chromatin organization precede early gene activation upon infection.
The EMBO Journal.
Wernig-Zorc, Sara
(2023)
Gene regulation via nucleosome stability modulation and RNA:DNA triplex formation.
Dissertation, Universität Regensburg.
Hoffmeister, Helen, Holzinger, Simon
, Dürr, Marie-Sofie, Bruckmann, Astrid, Schindler, Susann G., Gröbner-Ferreira, Regina, Depping, Reinhard und Längst, Gernot
(2023)
Characterization of the nuclear import of the human CHD4–NuRD complex.
Journal of Cell Science 136 (7).
Markusch, Hanna, Michl‐Holzinger, Philipp, Obermeyer, Simon, Thorbecke, Claudia, Bruckmann, Astrid
, Babl, Sabrina, Längst, Gernot
, Osakabe, Akihisa, Berger, Frédéric und Grasser, Klaus D.
(2023)
Elongation factor 1 is a component of the Arabidopsis RNA polymerase II elongation complex and associates with a subset of transcribed genes.
New Phytologist 238 (1), S. 113-124.
(2023)
The chromatin – triple helix connection.
Biological Chemistry 404 (11-12), S. 1037-1049.
Volltext nicht vorhanden.
Siegel, Michael F.
(2022)
Characterization of stable cell lines, inducibly co-expressing CHD3/4 with PU.1.
Dissertation, Universität Regensburg.
Michl-Holzinger, Philipp, Obermeyer, Simon, Markusch, Hanna, Pfab, Alexander, Ettner, Andreas, Bruckmann, Astrid, Babl, Sabrina, Längst, Gernot, Schwartz, Uwe, Tvardovskiy, Andrey, Jensen, Ole N.
, Osakabe, Akihisa, Berger, Frédéric und Grasser, Klaus D.
(2022)
Phosphorylation of the FACT histone chaperone subunit SPT16 affects chromatin at RNA polymerase II transcriptional start sites in Arabidopsis.
Nucleic Acids Research 50 (9), S. 5014-5028.
, Thalhauser, Stefanie, Neckermann, Patrick
, Barbey, Clara, Straub, Kristina, Nazet, Julian, Merkl, Rainer, Längst, Gernot, Breunig, Miriam
und Wagner, Ralf
(2022)
Multivalent display of engineered HIV-1 envelope trimers on silica nanoparticles for targeting and in vitro activation of germline VRC01 B cells.
European Journal of Pharmaceutics and Biopharmaceutics 181, S. 88-101.
Volltext nicht vorhanden.
Schwartz, Uwe
(2021)
Functional Chromatin Extraction: A method to study DNA accessibility in higher-order structures of chromatin.
Dissertation, Universität Regensburg.
Längst, Gernot, Watzlowik, Maria Theresia, Das, Sujaan
und Meissner, Markus
(2021)
Peculiarities of Plasmodium falciparum Gene Regulation and Chromatin Structure.
International Journal of Molecular Sciences 2021 (22), S. 5168.
(Eingereicht)
Hoffmeister, Helen, Fuchs, Andreas
, Komives, Elizabeth, Groebner‐Ferreira, Regina, Strobl, Laura, Nazet, Julian, Heizinger, Leonhard, Merkl, Rainer, Dove, Stefan und Längst, Gernot
(2021)
Sequence and functional differences in the ATPase domains of CHD3 and SNF2H promise potential for selective regulability and drugability.
The FEBS Journal 288, S. 4000-4023.
, Rehimi, Rizwan, Kayserili, Hülya
, Brühl, Joanna, Sofiadis, Konstantinos, Zirkel, Anne, Palikyras, Spiros, Mizi, Athanasia, Li, Yun, Yigit, Gökhan
, Hoischen, Alexander
, Frank, Stefan, Russ, Nicole, Trautwein, Jonathan, van Bon, Bregje, Gilissen, Christian
, Laugsch, Magdalena, Gusmao, Eduardo Gade, Josipovic, Natasa
, Altmüller, Janine, Nürnberg, Peter, Längst, Gernot, Kaiser, Frank J., Watrin, Erwan, Brunner, Han, Rada-Iglesias, Alvaro
, Kurian, Leo
, Wollnik, Bernd
, Bouazoune, Karim und Papantonis, Argyris
(2021)
Overarching control of autophagy and DNA damage response by CHD6 revealed by modeling a rare human pathology.
Nature Communications 12 (1).
Volltext nicht vorhanden.
Maiser, Andreas
, Dillinger, Stefan, Längst, Gernot, Schermelleh, Lothar
, Leonhardt, Heinrich
und Németh, Attila
(2020)
Super-resolution in situ analysis of active ribosomal DNA chromatin organization in the nucleolus.
Scientific Reports 10 (7642), S. 1-11.
Minderjahn, Julia, Schmidt, Andreas, Fuchs, Andreas
, Schill, Rudolf, Raithel, Johanna, Babina, Magda
, Schmidl, C.
, Gebhard, Claudia, Schmidhofer, Sandra, Mendes, Karina
, Ratermann, Anna, Glatz, Dagmar, Nützel, Margit, Edinger, Matthias, Hoffmann, Petra, Spang, Rainer
, Längst, Gernot, Imhof, A. und Rehli, Michael
(2020)
Mechanisms governing the pioneering and redistribution capabilities of the non-classical pioneer PU.1.
Nat Commun 11, S. 402.
, Beynon, Jim, Falter-Braun, Pascal, Längst, Gernot, Dresselhaus, Thomas und Sprunck, Stefanie
(2020)
ARMADILLO REPEAT ONLY proteins confine Rho GTPase signalling to polar growth sites.
Nature Plants 6 (10), S. 1275-1288.
Volltext nicht vorhanden.
Maldonado, Rodrigo
(2019)
Characterization of Muscle Glycogen Synthase and its Association with RNA in Sertoli Cells.
Dissertation, Universität Regensburg.
Carrasco Wong, Ivo
(2019)
Oxidative stress-induced epigenetic transcriptional memory as a mechanism of programmed endothelial dysfunction in large for gestational age newborn of women with obesity.
Dissertation, Universität Regensburg.
Valenzuela Nieto, Guillermo Eduardo
(2019)
Study of genetic and epigenetic determinants of gene expression regulation for both SL genes in response to estrogen in common carp (Cyprinus carpio).
Dissertation, Universität Regensburg.
Bartoschik, Tanja Astrid
(2019)
Development and validation of new approaches for quantitative intermolecular interaction analysis by MicroScale Thermophoresis under near-native experimental conditions.
Dissertation, Universität Regensburg.
Araya Fuenzalida, Ingrid Carolina
(2019)
Functional characterization of HMGN5 in
(2019)
Antibody-targeted chromatin enables effective intracellular delivery and functionality of CRISPR/Cas9 expression plasmids.
Nucleic Acids Research 47 (10), e55-e55.
Volltext nicht vorhanden.
, Strobl, Laura, Sprenger, Frank, Gröbner-Ferreira, Regina, Michaelis, Stefanie, Hoffmann, Petra, Nazet, Julian, Merkl, Rainer
und Längst, Gernot
(2019)
Elucidation of the functional roles of the Q and I motifs in the human chromatin-remodeling enzyme BRG1.
Journal of Biological Chemistry 294 (9), S. 3294-3310.
Volltext nicht vorhanden.
, Le Gall, Sabine, Neyt, Pia
, Boccardi, Tommaso M., Grasser, Marion, Längst, Gernot, Aesaert, Stijn, Coussens, Griet, Dhondt, Stijn
, Van De Slijke, Eveline, Bruno, Leonardo, Fung-Uceda, Jorge, Mas, Paloma
, Van Montagu, Marc, Inzé, Dirk, Himanen, Kristiina
, De Jaeger, Geert, Grasser, Klaus D. und Van Lijsebettens, Mieke
(2019)
Histone 2B monoubiquitination complex integrates transcript elongation with RNA processing at circadian clock and flowering regulators.
Proceedings of the National Academy of Sciences 116 (16), S. 8060-8069.
Volltext nicht vorhanden.
, Sørensen, Brian B., Längst, Gernot, Sprunck, Stefanie, Grasser, Marion und Grasser, Klaus D.
(2019)
The UAP56-Interacting Export Factors UIEF1 and UIEF2 Function in mRNA Export.
Plant Physiology 179 (4), S. 1525-1536.
Volltext nicht vorhanden.
, Ramos Perlingeiro, Rita de Cassia, Jacobs, Laura A. und Cisneros, Bulmaro
(2019)
The intracellular domain of β-dystroglycan mediates the nucleolar stress response by suppressing UBF transcriptional activity.
Cell Death & Disease 10 (3).
Volltext nicht vorhanden.
Schwartz, Uwe, Németh, Attila, Diermeier, Sarah
, Exler, Josef H., Hansch, Stefan, Maldonado, Rodrigo, Heizinger, Leonhard
, Merkl, Rainer
und Längst, Gernot
(2018)
Characterizing the nuclease accessibility of DNA in human cells to map higher order structures of chromatin.
Nucleic Acids Research 2018 (1), S. 1-16.
, Sauer, Anja, Mačinković, Igor, Awe, Stephan, Finkernagel, Florian
, Hoffmeister, Helen, Fuchs, Andreas
, Müller, Rolf, Rathke, Christina, Längst, Gernot und Brehm, Alexander
(2018)
Tumour-associated missense mutations in the dMi-2 ATPase alters nucleosome remodelling properties in a mutation-specific manner.
Nature Communications 9 (1).
Volltext nicht vorhanden.
Hoffmeister, Helen, Fuchs, Andreas
, Erdel, Fabian
, Pinz, Sophia, Gröbner-Ferreira, Regina, Bruckmann, Astrid, Deutzmann, Rainer, Schwartz, Uwe, Maldonado, Rodrigo, Huber, Claudia, Dendorfer, Anne-Sarah, Rippe, Karsten und Längst, Gernot
(2017)
CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.
Nucleic Acids Research 45 (18), S. 10534-10554.
Längst, Gernot, König, Fabian und Schubert, Thomas E. O.
(2017)
The monoclonal S9.6 antibody exhibits highly variable binding affinities towards different R-loop sequences.
PLoS ONE 12 (6), e0178875.
Gross, Thomas
(2017)
Characterization of the Chromatin Remodeling Enzyme Lymphoid-Specific Helicase.
Dissertation, Universität Regensburg.
Längst, Gernot, Silberhorn, Elisabeth, Schwartz, Uwe, Löffler, Patrick
, Schmitz, Samuel, Symelka, Anne
, Koning-Ward, Tania de
und Merkl, Rainer
(2016)
Plasmodium falciparum Nucleosomes Exhibit Reduced Stability and Lost Sequence Dependent Nucleosome Positioning.
PLoS Pathogens 12 (12), e10060.
Vera Sepúlveda, Tamara Scarlett
(2016)
Differential gene expression of Piscirickettsia salmonis strains in adaptive response to different culture systems: a strategy to identify possible intracellular survival mechanisms and pathogenicity.
Dissertation, Universität Regensburg.
, Navarro, Cristina, Längst, Gernot und Alvarez, Marco
(2016)
Differential enrichment of TTF-I and Tip5 in the T-like promoter structures of the rDNA contribute to the epigenetic response of Cyprinus carpio during environmental adaptation.
Biochemistry and Cell Biology 94 (4), S. 315-321.
Volltext nicht vorhanden.
Längst, Gernot, Schrader, Anna, Gross, Thomas und Thalhammer, Verena
(2015)
Characterization of Dnmt1 Binding and DNA Methylation on Nucleosomes and Nucleosomal Arrays.
PLoS ONE 10 (10), e0140076.
Längst, Gernot und Manelyte, Laura
(2015)
Chromatin remodelers: from function to dysfunction.
Genes 2015 (6), S. 299-324.
, Petter, Michaela
, Oehring, Sophie C., Gupta, Archna P., Dietz, Olivier, Wilson, Danny W.
, Schubert, Thomas
, Längst, Gernot, Gilson, Paul R., Crabb, Brendan S., Moes, Suzette, Jenoe, Paul, Lim, Shu Wei, Brown, Graham V., Bozdech, Zbynek
, Voss, Till S. und Duffy, Michael F.
(2015)
A Plasmodium Falciparum Bromodomain Protein Regulates Invasion Gene Expression.
Cell Host & Microbe 17 (6), S. 741-751.
Volltext nicht vorhanden.
, Georgomanolis, Theodore, Zirkel, Anne, Diermeier, Sarah
, O'Reilly, Dawn, Murphy, Shona, Längst, Gernot, Cook, Peter R. und Papantonis, Argyris
(2015)
Splicing of many human genes involves sites embedded within introns.
Nucleic Acids Research 43 (9), S. 4721-4732.
Volltext nicht vorhanden.
, Plößl, Karolina, Schneider, Magdalena, Grassmann, Felix
, Fuchshofer, Rudolf
, Tiefenbach, Klaus-Jürgen, Längst, Gernot und Weber, Bernhard H. F.
(2015)
Synonymous variants in HTRA1 implicated in AMD susceptibility impair its capacity to regulate TGF-β signaling.
Human Molecular Genetics 24, S. 6361-6373.
Volltext nicht vorhanden.
Längst, Gernot, Gross, Thomas, Strohner, Ralf und Manelyte, Laura
(2014)
Chromatin targeting signals nucleosome positioning mechanism and non-coding RNA mediated regulation of the chromatin remodeling complex NoRC.
PLoS Genetics 10 (3), e1004157.
Diermeier, Sarah Daniela Helena
(2014)
Local and global analysis of the structure-function relation in chromatin.
Dissertation, Universität Regensburg.
, Löffler, Patrick, Längst, Gernot, Merkl, Rainer
, Urlaub, Henning und Meister, Gunter
(2014)
The NHL domain of BRAT is an RNA-binding domain that directly contacts the hunchback mRNA for regulation.
Genes & Development 28 (7), S. 749-764.
Volltext nicht vorhanden.
Diermeier, Sarah
, Nemmeth, Attila, Rehli, Michael
, Grummt, Ingrid und Längst, Gernot
(2013)
Chromatin-Specific Regulation of Mammalian rDNA Transcription by Clustered TTF-I Binding Sites.
PLoS Genetics 9.
Filarsky, Michael
(2013)
Exploring the role of structured DNA elements and their specific binders in genome regulation.
Dissertation, Universität Regensburg.
Huber, Claudia
(2013)
Deposition, positioning and dynamics of H2A.Z in Saccharomyces cerevisiae.
Dissertation, Universität Regensburg.
Nardocci, Gino Alberto
(2013)
Epigenetic regulation of Cyprinus carpio ribosomal cistron during the acclimatization process.
Dissertation, Universität Regensburg.
Kammel, Christine, Thomaier, Maren, Sørensen, Brian B., Schubert, Thomas
, Längst, Gernot, Grasser, Marion und Grasser, Klaus D.
(2013)
Arabidopsis DEAD-box RNA helicase UAP56 interacts with both RNA and DNA as well as with mRNA export factors.
PloS one 8 (3), e60644.
Manelyte, Laura und Längst, Gernot
(2013)
Chromatin Remodelers and Their Way of Action.
In: Radzioch, Daniela, (ed.)
Chromatin Remodelling.
, S. 3.
ISBN 978-953-51-1087-3.
Zillner, Karina, Filarsky, Michael, Rachow, Katrin, Weinberger, Michael, Längst, Gernot und Németh, Attila
(2013)
Large-scale organization of ribosomal DNA chromatin is regulated by Tip5.
Nucleic Acids Research 41 (10), S. 5251-5262.
Pham, Thu-Hang, Minderjahn, Julia, Schmidl, Christian, Hoffmeister, Helen, Schmidhofer, Sandra, Chen, Wei, Längst, Gernot, Benner, Christopher und Rehli, Michael
(2013)
Mechanisms of in vivo binding site selection of the hematopoietic master transcription factor PU.1.
Nucleic acids research 41 (13), S. 6391-6402.
Schubert, Thomas
(2012)
Df31 protein and snoRNAs maintain accessible higher order structures of chromatin.
Dissertation, Universität Regensburg.
, Pusch, Miriam Caroline, Diermeier, Sarah
, Benes, Vladimir
, Kremmer, Elisabeth, Imhof, Axel
und Längst, Gernot
(2012)
Df31 Protein and snoRNAs Maintain Accessible Higher-Order Structures of Chromatin.
Molecular Cell 48 (3), S. 434-444.
Volltext nicht vorhanden.
, Leonhardt, Heinrich, Keough, Rebecca, Gonda, Thomas J., Imhof, Axel
, Eick, Dirk, Längst, Gernot und Németh, Attila
(2012)
Myb-binding Protein 1a (Mybbp1a) Regulates Levels and Processing of Pre-ribosomal RNA.
Journal of Biological Chemistry 287 (29), S. 24365-24377.
Volltext nicht vorhanden.
Felle, Max, Hoffmeister, Helen, Rothammer, Julia, Fuchs, Andreas
, Exler, Josef H. und Längst, Gernot
(2011)
Nucleosomes protect DNA from DNA methylation in vivo and in vitro.
Nucleic Acids Research 39, S. 6956.
, Krug, Jana, Längst, Gernot und Rippe, Karsten
(2011)
Targeting chromatin remodelers: Signals and search mechanisms.
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1809 (9), S. 497-508.
Volltext nicht vorhanden.
Felle, Max, Joppien, Saskia, Németh, Attila, Diermeier, Sarah
, Thalhammer, Verena, Dobner, Thomas, Kremmer, Elisabeth, Kappler, Roland
und Längst, Gernot
(2011)
The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1.
Nucleic Acids Research 39, S. 8355.
Schrader, Anna
(2010)
Molecular mechanisms of nucleosome positioning and DNA methylation in chromatin.
Dissertation, Universität Regensburg.
Felle, Max
(2010)
DNA methylation in chromatin - complexes and mechanisms.
Dissertation, Universität Regensburg.
Nitzsche, Alexandra
(2010)
Epigenetische Organisation des Cytomegalievirus-Genoms.
Dissertation, Universität Regensburg.
, Dachauer, Karoline, Brehm, Alexander, Grummt, Ingrid und Längst, Gernot
(2010)
DNA sequence encoded repression of rRNA gene transcription in chromatin.
Nucleic acids research 38 (16), S. 5304-5314.
Volltext nicht vorhanden.
und Eick, Dirk
(2010)
Defects in 18 S or 28 S rRNA Processing Activate the p53 Pathway.
Journal of Biological Chemistry 285 (9), S. 6364-6370.
Volltext nicht vorhanden.
, Waldmann, Tanja, Ettig, Ramona, Braun, Lora, Izzo, Annalisa
, Daujat, Sylvain, Chassignet, Isabelle, Lopez-Contreras, Andres Joaquin
, Fernandez-Capetillo, Oscar, Dundr, Miroslav
, Rippe, Karsten, Längst, Gernot und Schneider, Robert
(2010)
Histone H2A C-Terminus Regulates Chromatin Dynamics, Remodeling, and Histone H1 Binding.
PLoS Genetics 6 (12), e1001234.
Volltext nicht vorhanden.
, Schubert, Thomas
, Marth, Caroline, Längst, Gernot und Rippe, Karsten
(2010)
Human ISWI chromatin-remodeling complexes sample nucleosomes via transient binding reactions and become immobilized at active sites.
Proceedings of the National Academy of Sciences 107 (46), S. 19873-19878.
Volltext nicht vorhanden.
, Santoyo-Lopez, Javier
, Medina, Ignacio
, Montaner, David, Péterfia, Bálint
, Solovei, Irina
, Cremer, Thomas
, Dopazo, Joaquin und Längst, Gernot
(2010)
Initial Genomics of the Human Nucleolus.
PLoS Genetics 6 (3), e1000889.
Volltext nicht vorhanden.
, Felle, Max, Längst, Gernot und Leonhardt, Heinrich
(2009)
Dimerization of DNA methyltransferase 1 is mediated by its regulatory domain.
Journal of Cellular Biochemistry 106 (4), S. 521-528.
Volltext nicht vorhanden.
und Brehm, Alexander
(2008)
dCHD3, a Novel ATP-Dependent Chromatin Remodeler Associated with Sites of Active Transcription.
Molecular and Cellular Biology 28 (8), S. 2745-2757.
Volltext nicht vorhanden.
, Haemmer, Andrea, Kuch, David, Rothbauer, Ulrich
, Schermelleh, Lothar
, Kremmer, Elisabeth, Carell, Thomas
, Längst, Gernot und Leonhardt, Heinrich
(2007)
DNMT1 but not its interaction with the replication machinery is required for maintenance of DNA methylation in human cells.
The Journal of Cell Biology 176 (5), S. 565-571.
Volltext nicht vorhanden.
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