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Increased expression of c-Jun in nonalcoholic fatty liver disease

Dorn, Christoph, Engelmann, Julia C., Saugspier, Michael Sebastian, Koch, Andreas, Hartmann, Arndt, Spang, Rainer, Bosserhoff, Anja Katrin and Hellerbrand, Claus (2014) Increased expression of c-Jun in nonalcoholic fatty liver disease. Laboratory Investigation 94, pp. 394-408.

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Abstract

Overnutrition is the major cause of nonalcoholic fatty liver disease (NAFLD) and its advanced form nonalcoholic steatohepatitis (NASH). We aimed to develop and characterize a murine model, which resembles both the pathology and nutritional situation, of NASH patients in Western societies. Mice were fed with a NASH-inducing diet (ND) containing sucrose, cholesterol and fats rich in saturated fatty ...

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Item type:Article
Date:3 February 2014
Additional Information (public):Advance online publication 3 February 2014
Institutions:Medicine > Lehrstuhl für Innere Medizin I
Medicine > Lehrstuhl für Pathologie
Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Statistische Bioinformatik (Prof. Spang)
Identification Number:
ValueType
10.1038/labinvest.2014.3DOI
24492282PubMed ID
Keywords:AP-1; c-Jun; metabolic syndrome; NAFLD; NASH Animals; Dietary Fats, adverse effects; Disease Models, Animal; Fatty Liver, etiology/metabolism/pathology; Fibrosis; Gene Expression; Humans; Lipid Metabolism; Liver, pathology; Male; Metabolic Syndrome X, etiology; Mice; Mice, Inbred C57BL; Obesity, etiology; Oxidative Stress; Proto-Oncogene Proteins c-jun, metabolism; Sucrose, adverse effects
Dewey Decimal Classification:500 Science > 500 Natural sciences & mathematics
500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:30490
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