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Exact likelihood computation in Boolean networks with probabilistic time delays, and its application in signal network reconstruction.

URN to cite this document:
urn:nbn:de:bvb:355-epub-305237
Dümcke, Sebastian ; Bräuer, Johannes ; Anchang, Benedict Nchang ; Spang, Rainer ; Beerenwinkel, Niko ; Tresch, Achim
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Date of publication of this fulltext: 05 Aug 2014 08:14


Abstract

MOTIVATION: For biological pathways, it is common to measure a gene expression time series after various knockdowns of genes that are putatively involved in the process of interest. These interventional time-resolved data are most suitable for the elucidation of dynamic causal relationships in signaling networks. Even with this kind of data it is still a major and largely unsolved challenge to ...

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