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Different patterns of Epstein-Barr virus latency in endemic Burkitt lymphoma (BL) lead to distinct variants within the BL-associated gene expression signature

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Kelly, Gemma L ; Stylianou, Julianna ; Rasaiyaah, Jane ; Wei, Wenbin ; Thomas, Wendy ; Croom-Carter, Deborah ; Kohler, Christian ; Spang, Rainer ; Woodman, Ciaran ; Kellam, Paul ; Rickinson, Alan N. ; Bell, Andrew I.
Date of publication of this fulltext: 05 Aug 2014 09:41


Epstein-Barr virus (EBV) is present in all cases of endemic Burkitt lymphoma (BL) but in few European/North American sporadic BLs. Gene expression arrays of sporadic tumors have defined a consensus BL profile within which tumors are classifiable as "molecular BL" (mBL). Where endemic BLs fall relative to this profile remains unclear, since they not only carry EBV but also display one of two ...


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