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Early changes in the liver-soluble proteome from mice fed a nonalcoholic steatohepatitis inducing diet

Thomas, Anja ; Stevens, Axel Peter ; Klein, Matthias S. ; Hellerbrand, Claus ; Dettmer, Katja ; Gronwald, Wolfram ; Oefner, Peter J. ; Reinders, Jörg



Abstract

Despite the increasing incidence of nonalcoholic steatohepatitis (NASH) with the rise in lifestyle-related diseases such as the metabolic syndrome, little is known about the changes in the liver proteome that precede the onset of inflammation and fibrosis. Here, we investigated early changes in the liver-soluble proteome of female C57BL/6N mice fed an NASH-inducing diet by 2D-DIGE and ...

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