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Early changes in the liver-soluble proteome from mice fed a nonalcoholic steatohepatitis inducing diet

Thomas, Anja, Stevens, Axel Peter, Klein, Matthias S., Hellerbrand, Claus, Dettmer, Katja, Gronwald, Wolfram, Oefner, Peter J. and Reinders, Jörg (2012) Early changes in the liver-soluble proteome from mice fed a nonalcoholic steatohepatitis inducing diet. Proteomics 12 (9), pp. 1437-1451.

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Abstract

Despite the increasing incidence of nonalcoholic steatohepatitis (NASH) with the rise in lifestyle-related diseases such as the metabolic syndrome, little is known about the changes in the liver proteome that precede the onset of inflammation and fibrosis. Here, we investigated early changes in the liver-soluble proteome of female C57BL/6N mice fed an NASH-inducing diet by 2D-DIGE and ...

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Item type:Article
Date:May 2012
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Identification Number:
ValueType
22589191PubMed ID
10.1002/pmic.201100628DOI
Classification:
NotationType
Analysis of VarianceMESH
AnimalsMESH
Cholesterol/metabolismMESH
DietMESH
Electrophoresis, Gel, Two-DimensionalMESH
Fatty Liver/metabolismMESH
FemaleMESH
Glycerol/metabolismMESH
ImmunohistochemistryMESH
Liver/metabolismMESH
MetabolomicsMESH
MiceMESH
Mice, Inbred C57BLMESH
Proteome/metabolismMESH
ProteomicsMESH
Reproducibility of ResultsMESH
S-Adenosylmethionine/metabolismMESH
Keywords:Animal proteomics; Liver proteome;Metabolomics; Nonalcoholic steatohepatitis; Two-dimensional differential in-gel electrophoresis
Dewey Decimal Classification:500 Science > 500 Natural sciences & mathematics
500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:30582
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