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Deep sequencing of MYC DNA-binding sites in Burkitt lymphoma

Seitz, Volkhard, Butzhammer, Peter, Hirsch, Burkhard, Hecht, Jochen, Gütgemann, Ines, Ehlers, Anke, Lenze, Dido, Oker, Elisabeth, Sommerfeld, Anke, von der Wall, Edda, König, Christoph, Zinser, Christian, Spang, Rainer and Hummel, Michael (2011) Deep sequencing of MYC DNA-binding sites in Burkitt lymphoma. PLoS One 6 (11), e26837.

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Abstract

BACKGROUND: MYC is a key transcription factor involved in central cellular processes such as regulation of the cell cycle, histone acetylation and ribosomal biogenesis. It is overexpressed in the majority of human tumors including aggressive B-cell lymphoma. Especially Burkitt lymphoma (BL) is a highlight example for MYC overexpression due to a chromosomal translocation involving the c-MYC gene. ...

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Item type:Article
Date:2011
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Statistische Bioinformatik (Prof. Spang)
Identification Number:
ValueType
22102868PubMed ID
10.1371/journal.pone.0026837DOI
Classification:
NotationType
Binding SitesMESH
Burkitt Lymphoma/metabolismMESH
Chromatin ImmunoprecipitationMESH
DNA, Neoplasm/geneticsMESH
Gene Expression ProfilingMESH
Gene Expression Regulation, NeoplasticMESH
Genome, HumanMESH
High-Throughput Nucleotide SequencingMESH
HumansMESH
Oligonucleotide Array Sequence AnalysisMESH
Proto-Oncogene Proteins c-myc/metabolismMESH
RNA, Small Interfering/geneticsMESH
Tumor Cells, CulturedMESH
Tumor Markers, Biological/geneticsMESH
Dewey Decimal Classification:500 Science > 500 Natural sciences & mathematics
500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:30608
Owner only: item control page

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