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Deep sequencing of MYC DNA-binding sites in Burkitt lymphoma

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Seitz, Volkhard ; Butzhammer, Peter ; Hirsch, Burkhard ; Hecht, Jochen ; Gütgemann, Ines ; Ehlers, Anke ; Lenze, Dido ; Oker, Elisabeth ; Sommerfeld, Anke ; von der Wall, Edda ; König, Christoph ; Zinser, Christian ; Spang, Rainer ; Hummel, Michael
License: Creative Commons Attribution 3.0
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Date of publication of this fulltext: 12 Aug 2014 07:24


BACKGROUND: MYC is a key transcription factor involved in central cellular processes such as regulation of the cell cycle, histone acetylation and ribosomal biogenesis. It is overexpressed in the majority of human tumors including aggressive B-cell lymphoma. Especially Burkitt lymphoma (BL) is a highlight example for MYC overexpression due to a chromosomal translocation involving the c-MYC gene. ...


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