Deep sequencing of MYC DNA-binding sites in Burkitt lymphoma

URN to cite this document:: urn:nbn:de:bvb:355-epub-306084
DOI to cite this document:: 10.5283/epub.30608

Seitz, Volkhard ; Butzhammer, Peter ; Hirsch, Burkhard ; Hecht, Jochen ; Gütgemann, Ines ; Ehlers, Anke ; Lenze, Dido ; Oker, Elisabeth ; Sommerfeld, Anke ; von der Wall, Edda ; König, Christoph ; Zinser, Christian ; Spang, Rainer ; Hummel, Michael

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Date of publication of this fulltext: 12 Aug 2014 07:24

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Abstract

BACKGROUND: MYC is a key transcription factor involved in central cellular processes such as regulation of the cell cycle, histone acetylation and ribosomal biogenesis. It is overexpressed in the majority of human tumors including aggressive B-cell lymphoma. Especially Burkitt lymphoma (BL) is a highlight example for MYC overexpression due to a chromosomal translocation involving the c-MYC gene. ...