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Transcriptome asymmetry within mouse zygotes but not between early embryonic sister blastomeres

VerMilyea, Matthew ; Maneck, Matthias ; Yoshida, Naoko ; Blochberger, Isabell ; Suzuki, Emi ; Suzuki, Toru ; Spang, Rainer ; Klein, Christoph A. ; Perry, Anthony C. F.



Abstract

Transcriptome regionalization is an essential polarity determinant among metazoans, directing embryonic axis formation during normal development. Although conservation of this principle in mammals is assumed, recent evidence is conflicting and it is not known whether transcriptome asymmetries exist within unfertilized mammalian eggs or between the respective cleavage products of early embryonic ...

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