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Transcriptome asymmetry within mouse zygotes but not between early embryonic sister blastomeres

VerMilyea, Matthew, Maneck, Matthias, Yoshida, Naoko, Blochberger, Isabell, Suzuki, Emi, Suzuki, Toru, Spang, Rainer, Klein, Christoph A. and Perry, Anthony C. F. (2011) Transcriptome asymmetry within mouse zygotes but not between early embryonic sister blastomeres. The EMBO journal 30 (9), pp. 1841-1851.

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Abstract

Transcriptome regionalization is an essential polarity determinant among metazoans, directing embryonic axis formation during normal development. Although conservation of this principle in mammals is assumed, recent evidence is conflicting and it is not known whether transcriptome asymmetries exist within unfertilized mammalian eggs or between the respective cleavage products of early embryonic ...

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Item type:Article
Date:May 2011
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Statistische Bioinformatik (Prof. Spang)
Identification Number:
ValueType
21468028PubMed ID
10.1038/emboj.2011.92DOI
Classification:
NotationType
AnimalsMESH
Blastomeres/metabolismMESH
Body Patterning/physiologyMESH
Cluster AnalysisMESH
DNA Primers/geneticsMESH
Gene Expression ProfilingMESH
Gene Expression Regulation, Developmental/physiologyMESH
MiceMESH
Microarray AnalysisMESH
Polymerase Chain ReactionMESH
Zygote/metabolismMESH
Dewey Decimal Classification:500 Science > 500 Natural sciences & mathematics
500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:30609
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