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Human nephrosclerosis triggers a hypoxia-related glomerulopathy

Neusser, Matthias A. ; Lindenmeyer, Maja T. ; Moll, Anton G. ; Segerer, Stephan ; Edenhofer, Ilka ; Sen, Kontheari ; Stiehl, Daniel P. ; Kretzler, Matthias ; Gröne, Hermann-Josef ; Schlöndorff, Detlef ; Cohen, Clemens D.


In the kidney, hypoxia contributes to tubulointerstitial fibrosis, but little is known about its implications for glomerular damage and glomerulosclerosis. Chronic hypoxia was hypothesized to be involved in nephrosclerosis (NSC) or "hypertensive nephropathy." In the present study genome-wide expression data from microdissected glomeruli were studied to examine the role of hypoxia in ...


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