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Transcript-specific expression profiles derived from sequence-based analysis of standard microarrays

URN to cite this document:
urn:nbn:de:bvb:355-epub-306728
Moll, Anton G. ; Lindenmeyer, Maja T. ; Kretzler, Matthias ; Nelson, Peter J. ; Zimmer, Ralf ; Cohen, Clemens D.
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Date of publication of this fulltext: 19 Aug 2014 07:57


Abstract

BACKGROUND: Alternative mRNA processing mechanisms lead to multiple transcripts (i.e. splice isoforms) of a given gene which may have distinct biological functions. Microarrays like Affymetrix GeneChips measure mRNA expression of genes using sets of nucleotide probes. Until recently probe sets were not designed for transcript specificity. Nevertheless, the re-analysis of established microarray ...

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