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Response-Predictive Gene Expression Profiling of Glioma Progenitor Cells In Vitro

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Hau, Peter ; Moeckel, Sylvia ; Meyer, Katharina ; Leukel, Petra ; Heudorfer, Fabian ; Seliger, Corinna ; Stangl, Christina ; Bogdahn, Ulrich ; Proescholdt, Martin A. ; Brawanski, Alexander ; Vollmann-Zwerenz, Arabel ; Riemenschneider, Markus J. ; Bosserhoff, Anja-Katrin ; Spang, Rainer
Date of publication of this fulltext: 06 Oct 2014 13:16


Background High-grade gliomas are amongst the most deadly human tumors. Treatment results are disappointing. Still, in several trials around 20% of patients respond to therapy. To date, diagnostic strategies to identify patients that will profit from a specific therapy do not exist. Methods In this study, we used serum-free short-term treated in vitro cell cultures to predict treatment response ...


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