Response-Predictive Gene Expression Profiling of Glioma Progenitor Cells In Vitro

URN to cite this document:: urn:nbn:de:bvb:355-epub-308511
DOI to cite this document:: 10.5283/epub.30851

Hau, Peter ; Moeckel, Sylvia ; Meyer, Katharina ; Leukel, Petra ; Heudorfer, Fabian ; Seliger, Corinna ; Stangl, Christina ; Bogdahn, Ulrich ; Proescholdt, Martin A. ; Brawanski, Alexander ; Vollmann-Zwerenz, Arabel ; Riemenschneider, Markus J. ; Bosserhoff, Anja-Katrin ; Spang, Rainer

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Date of publication of this fulltext: 06 Oct 2014 13:16

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Abstract

Background High-grade gliomas are amongst the most deadly human tumors. Treatment results are disappointing. Still, in several trials around 20% of patients respond to therapy. To date, diagnostic strategies to identify patients that will profit from a specific therapy do not exist. Methods In this study, we used serum-free short-term treated in vitro cell cultures to predict treatment response ...