New insights into the cross-linking and degradation mechanism of Diels–Alder hydrogels

URN to cite this document:: urn:nbn:de:bvb:355-epub-312289
DOI to cite this document:: 10.5283/epub.31228

Kirchhof, Susanne ; Strasser, Andrea ; Wittmann, Hans-Joachim ; Messmann, Viktoria ; Hammer, Nadine ; Goepferich, Achim ; Brandl, Ferdinand

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Date of publication of this fulltext: 15 Jan 2015 14:33

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Abstract

Eight-armed poly(ethylene glycol) was functionalized with furyl and maleimide groups. The two macromonomers were cross-linked by Diels–Alder (DA) reactions and the degradation behavior of the formed hydrogels was investigated. UV spectroscopy showed that maleimide groups were subject to ring-opening hydrolysis above pH 5.5, with the reaction rate depending on the pH and temperature. As a result ...