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Layer-by-Layer assembled thin films for drug delivery: Interactions at the nano-bio interface

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Wurster, Eva-Christina
Date of publication of this fulltext: 02 Jun 2016 12:09

Abstract (English)

This thesis was focused on the interactions of Layer-by-Layer (LbL) thin films with biological counterparts during a drug delivery scenario. Several physiological barriers of an organism, the adsorption of serum proteins, the cellular association or the barrier function of biological hydrogels, limit the transport efficacy and hence the therapeutic effect of a drug delivery system. All those ...


Translation of the abstract (German)

In der vorliegenden Arbeit wurden die Wechselwirkungen von sogenannten Layer-by-Layer Dünnfilmen und möglichen biologischen Barrieren in einem Wirkstofftransportmodell untersucht. Verschiedene physiologische Barrieren eines Organismus, die Adsorption von Serumproteinen, die Zellassoziation oder die Barrierefunktion biologischer Hydrogele, limitieren die Transporteffizienz und letztendlich den ...


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